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3-Isobutyl-1-methylxanthine - 99%, high purity , CAS No.28822-58-4, Antagonist of A 1 receptor

12 Citations
Item Number
I106812
Grouped product items
SKUSizeAvailabilityPrice Qty
I106812-100mg
100mg
In stock
$54.90
I106812-250mg
250mg
In stock
$86.90
I106812-1g
1g
In stock
$245.90
I106812-5g
5g
In stock
$1,049.90
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Non-specific cAMP and cGMP inhibitor

View related series
A1 receptor Antagonist Phosphodiesterase (PDE)

Basic Description

SynonymsIBMX | 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione | 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione | 1-Methyl-3-isobutylxanthine
Specifications & PurityMoligand™, ≥99%
Biochemical and Physiological MechanismsNon-specific cAMP and cGMP inhibitor
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of A 1 receptor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.

Associated Targets(Human)

PDE3B Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase B (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ADORA1 Tclin Adenosine receptor A1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4B Tclin Phosphodiesterase 4B (2748 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3B Tclin Phosphodiesterase 3B (312 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE7A Tclin Phosphodiesterase 7A (1104 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE9A Tchem Phosphodiesterase 9A (1131 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HEK293 (82097 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Monocyte (474 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Skin (286 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC16A3 Tchem Monocarboxylate transporter 4 (196 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4 (3344 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE1A Tclin Phosphodiesterase 1 (671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase; PDE3 & PDE4 (301 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE7A Tclin Phosphodiesterase 7 (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine receptor (26 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE5A Tclin PDE5A/PDE6C (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

PDE2A Phosphodiesterase 2A (77 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde8a Phosphodiesterase 8A (1 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Canis familiaris (36305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
3T3-L1 (3664 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GCN5 Histone acetyltransferase GCN5 (89 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Adora2b Adenosine A2 receptor (1828 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Scn2a Sodium channel alpha subunits; brain (Types I, II, III) (344 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE1B Heart phosphodiesterase (70 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDEB1 Class I phosphodiesterase PDEB1 (2 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SARS-CoV-2 (38078 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
INCHI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
InChi Key APIXJSLKIYYUKG-UHFFFAOYSA-N
Canonical SMILES CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2
Isomeric SMILES CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2
WGK Germany 3
RTECS ZD8500000
PubChem CID 3758
Molecular Weight 222.24
Beilstein 247859

Certificates

Certificate of Analysis(COA)

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24 results found

Lot NumberCertificate TypeDateItem
G2408564Certificate of AnalysisJun 27, 2024 I106812
G2408563Certificate of AnalysisJun 27, 2024 I106812
G2408562Certificate of AnalysisJun 27, 2024 I106812
I2321591Certificate of AnalysisSep 06, 2023 I106812
I2321542Certificate of AnalysisSep 06, 2023 I106812
I2321541Certificate of AnalysisSep 06, 2023 I106812
I2321540Certificate of AnalysisSep 06, 2023 I106812
I2321523Certificate of AnalysisSep 06, 2023 I106812
I2321522Certificate of AnalysisSep 06, 2023 I106812
F2406088Certificate of AnalysisSep 06, 2023 I106812
I2321736Certificate of AnalysisSep 06, 2023 I106812
I2321749Certificate of AnalysisSep 06, 2023 I106812
E2407058Certificate of AnalysisSep 06, 2023 I106812
D2429037Certificate of AnalysisSep 06, 2023 I106812
K2201521Certificate of AnalysisSep 15, 2022 I106812
K2201527Certificate of AnalysisSep 15, 2022 I106812
K2201529Certificate of AnalysisSep 15, 2022 I106812
K2201548Certificate of AnalysisSep 15, 2022 I106812
F2217136Certificate of AnalysisJun 01, 2022 I106812
F2217116Certificate of AnalysisJun 01, 2022 I106812
F2217114Certificate of AnalysisJun 01, 2022 I106812
F2217109Certificate of AnalysisJun 01, 2022 I106812
B2209108Certificate of AnalysisFeb 11, 2022 I106812
A2219158Certificate of AnalysisFeb 11, 2022 I106812

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Chemical and Physical Properties

Melt Point(°C)200-203°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3
RTECS ZD8500000

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. 3-Isobutyl-1-methylxanthine - 10mM in DMSO, used for , CAS No. 28822-58-4, by Aladdin Scientific
    3-Isobutyl-1-methylxanthine

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Citations of This Product

1. Ling Yang, Linzi Li, Qian Lu, Lingfeng Li, Chun Xie, Fakun Jiang, Hongbing Li, Ai Zhao, Qian Wang, Wenyong Xiong.  (2023)  Alisol B blocks the development of HFD-induced obesity by triggering the LKB1-AMPK signaling in subcutaneous adipose tissue.  EUROPEAN JOURNAL OF PHARMACOLOGY,  956  (175942).  [PMID:37536624]
2. Gui-Bo Liu, Yong-Xia Cheng, Hua-Min Li, Yong Liu, Li-Xin Sun, Qi Wu, Shang-Fu Guo, Ting-Ting Li, Chuan-Ling Dong, Ge Sun.  (2023)  Ghrelin promotes cardiomyocyte differentiation of adipose tissue‑derived mesenchymal stem cells by DDX17‑mediated regulation of the SFRP4/Wnt/β‑catenin axis.  Molecular Medicine Reports,  28  (3): (1-14).  [PMID:37449526]
3. Xinyan Tao, Yuan Liu, Zhenhua Ding, Shuang Xie, Wenxiong Cao, Xiaohong Li.  (2023)  Injectable cell-targeting fiber rods to promote lipolysis and regulate inflammation for obesity treatment.  Biomaterials Science,      [PMID:37432672]
4. Yawei Kong, Jianpeng Ao, Qiushu Chen, Wenhua Su, Yinping Zhao, Yiyan Fei, Jiong Ma, Minbiao Ji, Lan Mi.  (2023)  Evaluating Differentiation Status of Mesenchymal Stem Cells by Label-Free Microscopy System and Machine Learning.  Cells,  12  (11): (1524).  [PMID:37296645]
5. Gao Rongyin, Zhang Ximei, Zou Kun, Meng Duo, Lv Jinpeng.  (2023)  Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway.  Frontiers in Pharmacology,  14    [PMID:36814484]
6. Xiaoxue Ren, Xiaoting Gao, Yicheng Cheng, Lingxia Xie, Liping Tong, Wei Li, Paul K. Chu, Huaiyu Wang.  (2022)  Maintenance of multipotency of bone marrow mesenchymal stem cells on poly(ε-caprolactone) nanoneedle arrays through the enhancement of cell-cell interaction.  Frontiers in Bioengineering and Biotechnology,  10  (1076345).  [PMID:36698633]
7. Fei He, Chendong Yang, Haoye Liu, Jizeng Wang.  (2023)  Changes in the mechanical properties of human mesenchymal stem cells during differentiation.  Royal Society Open Science,  10  (1):   [PMID:36636310]
8. Xiaoyu Cai, Songxue Wang, Huali Wang, Suwen Liu, Guishan Liu, Huibin Chen, Ji Kang, Hao Wang.  (2023)  Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro.  Food Science and Human Wellness,  12  (1174).  [PMID:]
9. Shuai Chen, Yicheng Jiang, Xiaoyang Qi, Peng Song, Liming Tang, Hanyang Liu.  (2022)  Bioinformatics analysis to obtain critical genes regulated in subcutaneous adipose tissue after bariatric surgery.  Adipocyte,  11  (1): (550-561).  [PMID:36036283]
10. Zhu Shenglong, Zhang Jingwei, Wang Wei, Jiang Xuan, Chen Yong Q..  (2022)  Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis.  JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,  78  (2): (377-388).  [PMID:35122619]
11. Zhu Shenglong, Wang Wei, Zhang Jingwei, Ji Siyu, Jing Zhe, Chen Yong Q..  (2022)  Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells.  CELLULAR & MOLECULAR BIOLOGY LETTERS,  27  (1): (1-13).  [PMID:35109789]
12. Luo M et al..  (2020)  Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling..  Biol Pharm Bull,  43  (7): (1027-1034).  [PMID:32404582]

References

1. Wang P et al..  (2022)  Disruption of adipocyte HIF-1α improves atherosclerosis through the inhibition of ceramide generation..  Acta Pharm Sin B,  12  (4): (1899-1912).  [PMID:35847503]
2. David T Manallack,Richard A Hughes,Philip E Thompson.  (2005-05-13)  The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases..  Journal of medicinal chemistry,  48  ((10)): (3449-3462).  [PMID:15887951]
3. Dezhong Yin,Zhuo Wang,Qinghong Gao,Renuka Sundaresan,Chris Parrish,Qingfen Yang,Paul H Krebsbach,Alexander C Lichtler,David W Rowe,Janet Hock,Peng Liu.  (2009-07-16)  Determination of the fate and contribution of ex vivo expanded human bone marrow stem and progenitor cells for bone formation by 2.3ColGFP..  Molecular therapy : the journal of the American Society of Gene Therapy,  17  ((11)): (1967-1978).  [PMID:19603005]
4. Hyun B Choi,Grant R J Gordon,Ning Zhou,Chao Tai,Ravi L Rungta,Jennifer Martinez,Teresa A Milner,Jae K Ryu,James G McLarnon,Martin Tresguerres,Lonny R Levin,Jochen Buck,Brian A MacVicar.  (2012-09-25)  Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase..  Neuron,  75  ((6)): (1094-1104).  [PMID:22998876]
5. G G Robins,K A MacLennan,R P Boot-Handford,G I Sandle.  (2012-11-28)  Rapid stimulation of human renal ENaC by cAMP in Xenopus laevis oocytes..  Journal of physiology and biochemistry,  69  ((3)): (419-427).  [PMID:23184731]
6. Angela Pignatelli,Mirta Borin,Alex Fogli Iseppe,Cristina Gambardella,Ottorino Belluzzi.  (2013-02-19)  The h-current in periglomerular dopaminergic neurons of the mouse olfactory bulb..  PloS one,  8  ((2)): (e56571-e56571).  [PMID:23418585]
7. Kyong-Suk Jin,You Na Oh,Sook Kyung Hyun,Hyun Ju Kwon,Byung Woo Kim.  (2014-03-19)  Betulinic acid isolated from Vitis amurensis root inhibits 3-isobutyl-1-methylxanthine induced melanogenesis via the regulation of MEK/ERK and PI3K/Akt pathways in B16F10 cells..  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,  68  (38-43).  [PMID:24632067]
8. Eri Nakamura,Fumio Otsuka,Tomohiro Terasaka,Kenichi Inagaki,Takeshi Hosoya,Naoko Tsukamoto-Yamauchi,Kishio Toma,Hirofumi Makino.  (2014-04-23)  Melatonin counteracts BMP-6 regulation of steroidogenesis by rat granulosa cells..  The Journal of steroid biochemistry and molecular biology,  143  (233-239).  [PMID:24751708]
9. Silin Pang,Huali Wu,Qian Wang,Minxuan Cai,Weimin Shi,Jing Shang.  (2014-05-24)  Chronic stress suppresses the expression of cutaneous hypothalamic-pituitary-adrenocortical axis elements and melanogenesis..  PloS one,  9  ((5)): (e98283-e98283).  [PMID:24854026]
10. Noriaki Kawanabe,Hiroaki Fukushima,Yoshihito Ishihara,Takeshi Yanagita,Hiroshi Kurosaka,Takashi Yamashiro.  (2014-05-28)  Isolation and characterization of SSEA-4-positive subpopulation of human deciduous dental pulp cells..  Clinical oral investigations,  19  ((2)): (363-371).  [PMID:24862940]
11. Robert K Amanfu,Jeffrey J Saucerman.  (2014-05-29)  Modeling the effects of β1-adrenergic receptor blockers and polymorphisms on cardiac myocyte Ca2+ handling..  Molecular pharmacology,  86  ((2)): (222-230).  [PMID:24867460]
12. A Priyanka,V M Nisha,S S Anusree,K G Raghu.  (2014-07-22)  Bilobalide attenuates hypoxia induced oxidative stress, inflammation, and mitochondrial dysfunctions in 3T3-L1 adipocytes via its antioxidant potential..  Free radical research,  48  ((10)): (1206-1217).  [PMID:25039303]
13. T Gelb,S Pshenichkin,O C Rodriguez,H A Hathaway,E Grajkowska,J O DiRaddo,B Wroblewska,R P Yasuda,C Albanese,B B Wolfe,J T Wroblewski.  (2014-07-30)  Metabotropic glutamate receptor 1 acts as a dependence receptor creating a requirement for glutamate to sustain the viability and growth of human melanomas..  Oncogene,  34  ((21)): (2711-2720).  [PMID:25065592]
14. Ruiping Zhou,Zhuokun Li,Chengyi He,Ronglin Li,Hongbin Xia,Chunyang Li,Jia Xiao,Zhi-Ying Chen.  (2014-08-08)  Human umbilical cord mesenchymal stem cells and derived hepatocyte-like cells exhibit similar therapeutic effects on an acute liver failure mouse model..  PloS one,  9  ((8)): (e104392-e104392).  [PMID:25101638]
15. Christina Maria Anna Pia Schuh,Philipp Heher,Anna Maria Weihs,Asmita Banerjee,Christiane Fuchs,Christian Gabriel,Susanne Wolbank,Rainer Mittermayr,Heinz Redl,Dominik Rünzler,Andreas Herbert Teuschl.  (2014-09-02)  In vitro extracorporeal shock wave treatment enhances stemness and preserves multipotency of rat and human adipose-derived stem cells..  Cytotherapy,  16  ((12)): (1666-1678).  [PMID:25174738]
16. Julia König,Gregor Weiss,Daniele Rossi,Karin Wankhammer,Andreas Reinisch,Manuela Kinzer,Berthold Huppertz,Dagmar Pfeiffer,Ornella Parolini,Ingrid Lang.  (2014-09-23)  Placental mesenchymal stromal cells derived from blood vessels or avascular tissues: what is the better choice to support endothelial cell function?.  Stem cells and development,  24  ((1)): (115-131).  [PMID:25244528]
17. Deepak Adhikari,M Kasim Diril,Kiran Busayavalasa,Sanjiv Risal,Shoma Nakagawa,Rebecca Lindkvist,Yan Shen,Vincenzo Coppola,Lino Tessarollo,Nobuaki R Kudo,Philipp Kaldis,Kui Liu.  (2014-09-24)  Mastl is required for timely activation of APC/C in meiosis I and Cdk1 reactivation in meiosis II..  The Journal of cell biology,  206  ((7)): (843-853).  [PMID:25246615]
18. Rui Wang,Jie Hong,Ruixin Liu,Maopei Chen,Min Xu,Wiqiong Gu,Yifei Zhang,Qinyun Ma,Feng Wang,Juan Shi,Jiqiu Wang,Weiqing Wang,Guang Ning.  (2014-10-18)  SFRP5 acts as a mature adipocyte marker but not as a regulator in adipogenesis..  Journal of molecular endocrinology,  53  ((3)): (405-415).  [PMID:25324487]
19. Yonghan He,Wen Li,Ying Li,Shuocheng Zhang,Yanwen Wang,Changhao Sun.  (2014-10-21)  Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes..  PloS one,  9  ((10)): (e110711-e110711).  [PMID:25329874]
20. Yu-Zhou Xiao,Sheng Wang.  (2014-11-06)  Differentiation of Schwann‑like cells from human umbilical cord blood mesenchymal stem cells in vitro..  Molecular medicine reports,  11  ((2)): (1146-1152).  [PMID:25369806]
21. SoRa Kim,Dae Hoon Kim,Young-Seok Kim,Tae-Young Ha,Jin Yang,Soo Hyun Park,Kwang Won Jeong,Jae-Keol Rhee.  (2014-11-22)  HD047703, a New Promising Anti-Diabetic Drug Candidate: In Vivo Preclinical Studies..  Biomolecules & therapeutics,  22  ((5)): (400-405).  [PMID:25414769]
22. Erika Mariana Palmieri,Iolanda Spera,Alessio Menga,Vittoria Infantino,Vito Iacobazzi,Alessandra Castegna.  (2014-12-03)  Glutamine synthetase desensitizes differentiated adipocytes to proinflammatory stimuli by raising intracellular glutamine levels..  FEBS letters,  588  ((24)): (4807-4814).  [PMID:25451225]
23. C Spits,L Guzman,A Mertzanidou,K Jacobs,C Ortega-Hrepich,R B Gilchrist,J G Thompson,M De Vos,J Smitz,K Sermon.  (2014-12-06)  Chromosome constitution of human embryos generated after in vitro maturation including 3-isobutyl-1-methylxanthine in the oocyte collection medium..  Human reproduction (Oxford, England),  30  ((3)): (653-663).  [PMID:25475586]
24. Marwan Mounayar,Eirini Kefaloyianni,Brian Smith,Zhabiz Solhjou,Omar H Maarouf,Jamil Azzi,Lola Chabtini,Paolo Fiorina,Morey Kraus,Robert Briddell,William Fodor,Andreas Herrlich,Reza Abdi.  (2015-03-11)  PI3kα and STAT1 Interplay Regulates Human Mesenchymal Stem Cell Immune Polarization..  Stem cells (Dayton, Ohio),  33  ((6)): (1892-1901).  [PMID:25753288]
25. Eun Hyoung Shim,Hoyoung Lee,Myeong Soo Lee.  (2015-03-11)  Effect of modified Chung-Sim-Youn-Ja-Tang on anti-inflammatory and anti-lipogenesis in RAW 264.7 and 3T3-L1 cells..  International journal of clinical and experimental pathology,  8  ((1)): (458-465).  [PMID:25755734]
26. Quynh-Anh NguyenThai,Neelesh Sharma,Do Huynh Luong,Simrinder Singh Sodhi,Jeong-Hyun Kim,Nameun Kim,Sung-Jong Oh,Dong Kee Jeong.  (2015-03-27)  Targeted inhibition of osteosarcoma tumor growth by bone marrow-derived mesenchymal stem cells expressing cytosine deaminase/5-fluorocytosine in tumor-bearing mice..  The journal of gene medicine,  17  ((3-5)): (87-99).  [PMID:25808408]
27. Kil-Nam Kim,Min-Cheol Kang,Nalae Kang,Seo-Young Kim,Chang-Gu Hyun,Seong Woon Roh,Eun-Yi Ko,Kichul Cho,Won-Kyo Jung,Ginnae Ahn,You-Jin Jeon,Daekyung Kim.  (2015-03-31)  2,4,6-Trihydroxybenzaldehyde, a potential anti-obesity treatment, suppressed adipocyte differentiation in 3T3-L1 cells and fat accumulation induced by high-fat diet in C57BL/6 mice..  Environmental toxicology and pharmacology,  39  ((2)): (962-968).  [PMID:25812771]
28. Amy L Strong,Annie C Bowles,Connor P MacCrimmon,Trivia P Frazier,Stephen J Lee,Xiying Wu,Adam J Katz,Barbara Gawronska-Kozak,Bruce A Bunnell,Jeffrey M Gimble.  (2015-04-23)  Adipose stromal cells repair pressure ulcers in both young and elderly mice: potential role of adipogenesis in skin repair..  Stem cells translational medicine,  4  ((6)): (632-642).  [PMID:25900728]
29. Johnny Suijker,Hans J Baelde,Helene Roelofs,Anne-Marie Cleton-Jansen,Judith V M G Bovée.  (2015-06-06)  The oncometabolite D-2-hydroxyglutarate induced by mutant IDH1 or -2 blocks osteoblast differentiation in vitro and in vivo..  Oncotarget,  6  ((17)): (14832-14842).  [PMID:26046462]
30. .  (2015-06-11)  Mesenchymal Stem Cells Improve Heart Rate Variability and Baroreflex Sensitivity in Rats with Chronic Heart Failure..  Stem cells and development,24(18),  2181-2192    [PMID:26059001]
31. Yeon Jeong Jang,Hyun Jung Koo,Eun-Hwa Sohn,Se Chan Kang,Dong-Kwon Rhee,Suhkneung Pyo.  (2015-06-19)  Theobromine inhibits differentiation of 3T3-L1 cells during the early stage of adipogenesis via AMPK and MAPK signaling pathways..  Food & function,  6  ((7)): (2365-2374).  [PMID:26085110]
32. Deng Li,Peng Wang,Yuxi Li,Zhongyu Xie,Le Wang,Hongjun Su,Wen Deng,Yanfeng Wu,Huiyong Shen.  (2015-07-01)  All-Trans Retinoic Acid Improves the Effects of Bone Marrow-Derived Mesenchymal Stem Cells on the Treatment of Ankylosing Spondylitis: An In Vitro Study..  Stem cells international,  2015  (484528-484528).  [PMID:26124839]
33. Weiwei An,Zhuzhen Zhang,Liyong Zeng,Ying Yang,Xueliang Zhu,Jiarui Wu.  (2015-07-15)  Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production..  PloS one,  10  ((7)): (e0132721-e0132721).  [PMID:26161966]
34. Santosh Nagaraju,Suzanne Bertera,Takayuki Tanaka,Hidetaka Hara,Gina R Rayat,Martin Wijkstrom,David Ayares,Massimo Trucco,David K C Cooper,Rita Bottino.  (2015-07-17)  In vitro exposure of pig neonatal isletlike cell clusters to human blood..  Xenotransplantation,  22  ((4)): (317-324).  [PMID:26179209]
35. Anna Wiktorowska-Owczarek,Jacek Owczarek.  (2015-07-24)  The effect of hypoxia on PGE2-stimulated cAMP generation in HMEC-1..  Cellular & molecular biology letters,  20  ((2)): (213-221).  [PMID:26204403]
36. Lei Li,Yunpeng Li,Hongkun Jiang.  (2015-07-26)  Neurotrophine-3 may contribute to neuronal differentiation of mesenchymal stem cells through the activation of the bone morphogenetic protein pathway..  Cellular & molecular biology letters,  20  ((3)): (385-403).  [PMID:26208387]
37. Meizi Zhang,Ying Zhang,Jun Ma,Feima Guo,Qian Cao,Yu Zhang,Bin Zhou,Jijie Chai,Wenqing Zhao,Renbin Zhao.  (2015-07-29)  The Demethylase Activity of FTO (Fat Mass and Obesity Associated Protein) Is Required for Preadipocyte Differentiation..  PloS one,  10  ((7)): (e0133788-e0133788).  [PMID:26218273]
38. Lara Gibellini,Sara De Biasi,Milena Nasi,Gianluca Carnevale,Alessandra Pisciotta,Elena Bianchini,Regina Bartolomeo,Miriam Polo,Anto De Pol,Marcello Pinti,Andrea Cossarizza.  (2015-08-05)  Different origin of adipogenic stem cells influences the response to antiretroviral drugs..  Experimental cell research,  337  ((2)): (160-169).  [PMID:26238601]
39. Yang-Ji Kim,Da-Hye Lee,Jiyun Ahn,Woo-Jae Chung,Young Jin Jang,Ki-Seung Seong,Jae-Hak Moon,Tae Youl Ha,Chang Hwa Jung.  (2015-09-01)  Pharmacokinetics, Tissue Distribution, and Anti-Lipogenic/Adipogenic Effects of Allyl-Isothiocyanate Metabolites..  PloS one,  10  ((8)): (e0132151-e0132151).  [PMID:26317351]
40. Marta Fernández-Galilea,Pablo Tapia,Kelly Cautivo,Eugenia Morselli,Víctor A Cortés.  (2015-09-30)  AGPAT2 deficiency impairs adipogenic differentiation in primary cultured preadipocytes in a non-autophagy or apoptosis dependent mechanism..  Biochemical and biophysical research communications,  467  ((1)): (39-45).  [PMID:26417690]
41. Sumit Bhattacharya,John F Imbery,Prince Tuffour Ampem,David R Giovannucci.  (2015-10-08)  Crosstalk between purinergic receptors and canonical signaling pathways in the mouse salivary gland..  Cell calcium,  58  ((6)): (589-597).  [PMID:26443524]
42. Karoline St-Martin Crites,Geneviève Morin,Valérie Orlando,Natacha Patey,Catherine Cantin,Judith Martel,Emmanuelle Brochiero,Geneviève Mailhot.  (2015-11-10)  CFTR Knockdown induces proinflammatory changes in intestinal epithelial cells..  Journal of inflammation (London, England),  12  (62-62).  [PMID:26549988]
43. Xiaofeng Wang,Pingping Wang,Zhuangzhuang Zhang,Jean-Claude Farré,Xuezhi Li,Ruonan Wang,Zhijie Xia,Suresh Subramani,Changle Ma.  (2019-04-23)  The autophagic degradation of cytosolic pools of peroxisomal proteins by a new selective pathway..  Autophagy,  16  ((1)): (154-166).  [PMID:31007124]
44. Ding Wang,Nengqing Liu,Yingjun Xie,Bing Song,Shu Kong,Xiaofang Sun.  (2020-03-03)  Different culture method changing CD105 expression in amniotic fluid MSCs without affecting differentiation ability or immune function..  Journal of cellular and molecular medicine,  24  ((7)): (4212-4222).  [PMID:32119193]
45. Adrienne Wright,Larry Snyder,Kaori Knights,Hong He,Nora L Springer,James Lillich,Mark L Weiss.  (2020-03-10)  A Protocol for the Isolation, Culture, and Cryopreservation of Umbilical Cord-Derived Canine Mesenchymal Stromal Cells: Role of Cell Attachment in Long-Term Maintenance..  Stem cells and development,  29  ((11)): (695-713).  [PMID:32148170]
46. Tiina Petäistö,David Vicente,Kari A Mäkelä,Mikko A Finnilä,Ilkka Miinalainen,Jarkko Koivunen,Valerio Izzi,Mari Aikio,Sanna-Maria Karppinen,Raman Devarajan,Jerome Thevenot,Karl-Heinz Herzig,Ritva Heljasvaara,Taina Pihlajaniemi.  (2020-05-26)  Lack of collagen XVIII leads to lipodystrophy and perturbs hepatic glucose and lipid homeostasis..  The Journal of physiology,  598  ((16)): (3373-3393).  [PMID:32449518]
47. Daniel L Villeneuve,Nathaniel D Mueller,Dalma Martinović,Elizabeth A Makynen,Michael D Kahl,Kathleen M Jensen,Elizabeth J Durhan,Jenna E Cavallin,David Bencic,Gerald T Ankley.  (2009-05-15)  Direct effects, compensation, and recovery in female fathead minnows exposed to a model aromatase inhibitor..  Environmental health perspectives,  117  ((4)): (624-631).  [PMID:19440503]
48. Shailesh R Agarwal,David A MacDougall,Richard Tyser,Sara D Pugh,Sarah C Calaghan,Robert D Harvey.  (2010-12-01)  Effects of cholesterol depletion on compartmentalized cAMP responses in adult cardiac myocytes..  Journal of molecular and cellular cardiology,  50  ((3)): (500-509).  [PMID:21115018]
49. M Y Jeong,H L Kim,J Park,Y Jung,D H Youn,J H Lee,J S Jin,H S So,R Park,S H Kim,S J Kim,S H Hong,J Y Um.  (2014-08-12)  Rubi Fructus (Rubus coreanus) activates the expression of thermogenic genes in vivo and in vitro..  International journal of obesity (2005),  39  ((3)): (456-464).  [PMID:25109782]
50. Carine Gubelmann,Petra C Schwalie,Sunil K Raghav,Eva Röder,Tenagne Delessa,Elke Kiehlmann,Sebastian M Waszak,Andrea Corsinotti,Gilles Udin,Wiebke Holcombe,Gottfried Rudofsky,Didier Trono,Christian Wolfrum,Bart Deplancke.  (2014-08-29)  Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network..  eLife,  3  (e03346-e03346).  [PMID:25163748]
51. Yu-Hua Chao,Han-Ping Wu,Kang-Hsi Wu,Yi-Giien Tsai,Ching-Tien Peng,Kuan-Chia Lin,Wan-Ru Chao,Maw-Sheng Lee,Yun-Ching Fu.  (2014-10-23)  An increase in CD3+CD4+CD25+ regulatory T cells after administration of umbilical cord-derived mesenchymal stem cells during sepsis..  PloS one,  9  ((10)): (e110338-e110338).  [PMID:25337817]
52. Jörg Schaarschmidt,Sandra Huth,René Meier,Ralf Paschke,Holger Jaeschke.  (2014-10-24)  Influence of the hinge region and its adjacent domains on binding and signaling patterns of the thyrotropin and follitropin receptor..  PloS one,  9  ((10)): (e111570-e111570).  [PMID:25340405]
53. Tao Nie,Xiaoyan Hui,Xuefei Gao,Baoming Nie,Liufeng Mao,Xiaofeng Tang,Ran Yuan,Kuai Li,Peng Li,Aimin Xu,Pengtao Liu,Sheng Ding,Weiping Han,Garth J S Cooper,Donghai Wu.  (2015-03-03)  Conversion of non-adipogenic fibroblasts into adipocytes by a defined hormone mixture..  The Biochemical journal,  467  ((3)): (487-494).  [PMID:25730278]
54. Monique J LeMieux,Nishan S Kalupahana,Shane Scoggin,Naima Moustaid-Moussa.  (2015-03-04)  Eicosapentaenoic acid reduces adipocyte hypertrophy and inflammation in diet-induced obese mice in an adiposity-independent manner..  The Journal of nutrition,  145  ((3)): (411-417).  [PMID:25733455]
55. Yao Xiong,Jing He,Wenjie Zhang,Guangdong Zhou,Yilin Cao,Wei Liu.  (2015-04-04)  Retention of the stemness of mouse adipose-derived stem cells by their expansion on human bone marrow stromal cell-derived extracellular matrix..  Tissue engineering. Part A,  21  ((11-12)): (1886-1894).  [PMID:25836590]
56. Takayuki Hara,Fumio Otsuka,Naoko Tsukamoto-Yamauchi,Kenichi Inagaki,Takeshi Hosoya,Eri Nakamura,Tomohiro Terasaka,Motoshi Komatsubara,Hirofumi Makino.  (2015-04-19)  Mutual effects of melatonin and activin on induction of aldosterone production by human adrenocortical cells..  The Journal of steroid biochemistry and molecular biology,  152  (8-15).  [PMID:25889901]
57. Haihong Lv,Tuanjie Che,Xulei Tang,Lijuan Liu,Jianguo Cheng.  (2015-04-22)  Puerarin enhances proliferation and osteoblastic differentiation of human bone marrow stromal cells via a nitric oxide/cyclic guanosine monophosphate signaling pathway..  Molecular medicine reports,  12  ((2)): (2283-2290).  [PMID:25892538]
58. Verena A Kottler,Axel Künstner,Iris Koch,Matthias Flötenmeyer,Tobias Langenecker,Margarete Hoffmann,Eshita Sharma,Detlef Weigel,Christine Dreyer.  (2015-06-17)  Adenylate cyclase 5 is required for melanophore and male pattern development in the guppy (Poecilia reticulata)..  Pigment cell & melanoma research,  28  ((5)): (545-558).  [PMID:26079969]
59. Gabriele Bonaventura,Sandrine Chamayou,Annalisa Liprino,Antonino Guglielmino,Michele Fichera,Massimo Caruso,Maria Luisa Barcellona.  (2015-10-31)  Different Tissue-Derived Stem Cells: A Comparison of Neural Differentiation Capability..  PloS one,  10  ((10)): (e0140790-e0140790).  [PMID:26517263]
60. Xiaona Qiao,Dong-Il Kim,Heejin Jun,Yingxu Ma,Alexander J Knights,Min-Jung Park,Kezhou Zhu,Jay H Lipinski,Jiling Liao,Yiming Li,Stéphane Richard,Steven A Weinman,Jun Wu.  (2019-09-27)  Protein Arginine Methyltransferase 1 Interacts With PGC1α and Modulates Thermogenic Fat Activation..  Endocrinology,  160  ((12)): (2773-2786).  [PMID:31555811]
61. Shu-Chun Chuang,Chung-Hwan Chen,Ya-Shuan Chou,Mei-Ling Ho,Je-Ken Chang.  (2020-09-10)  G Protein-Coupled Estrogen Receptor Mediates Cell Proliferation through the cAMP/PKA/CREB Pathway in Murine Bone Marrow Mesenchymal Stem Cells..  International journal of molecular sciences,  21  ((18)):   [PMID:32899453]
62. Jorge Chahla,Angela Papalamprou,Virginia Chan,Yasaman Arabi,Khosrawdad Salehi,Trevor J Nelson,Orr Limpisvasti,Bert R Mandelbaum,Wafa Tawackoli,Melodie F Metzger,Dmitriy Sheyn.  (2020-09-27)  Assessing the Resident Progenitor Cell Population and the Vascularity of the Adult Human Meniscus..  Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association,  37  ((1)): (252-265).  [PMID:32979500]
63. Sadatsugu Sakane,Hayato Hikita,Kumiko Shirai,Yuta Myojin,Youichi Sasaki,Shinnosuke Kudo,Kenji Fukumoto,Naoki Mizutani,Yuki Tahata,Yuki Makino,Ryoko Yamada,Takahiro Kodama,Ryotaro Sakamori,Tomohide Tatsumi,Tetsuo Takehara.  (2021-07-26)  White Adipose Tissue Autophagy and Adipose-Liver Crosstalk Exacerbate Nonalcoholic Fatty Liver Disease in Mice..  Cellular and molecular gastroenterology and hepatology,  12  ((5)): (1683-1699).  [PMID:34303881]
64. 荣晓音.  (2024)  CircMEF2C(2, 3) modulates proliferation and adipogenesis of porcine intramuscular preadipocytes by miR-383/671-3p/MEF2C axis.  iScience,  5  (27): (109710-).  [PMID:]
65. Ling Yang, Linzi Li, Qian Lu, Lingfeng Li, Chun Xie, Fakun Jiang, Hongbing Li, Ai Zhao, Qian Wang, Wenyong Xiong.  (2023)  Alisol B blocks the development of HFD-induced obesity by triggering the LKB1-AMPK signaling in subcutaneous adipose tissue.  EUROPEAN JOURNAL OF PHARMACOLOGY,  956  (175942).  [PMID:37536624]
66. Gui-Bo Liu, Yong-Xia Cheng, Hua-Min Li, Yong Liu, Li-Xin Sun, Qi Wu, Shang-Fu Guo, Ting-Ting Li, Chuan-Ling Dong, Ge Sun.  (2023)  Ghrelin promotes cardiomyocyte differentiation of adipose tissue‑derived mesenchymal stem cells by DDX17‑mediated regulation of the SFRP4/Wnt/β‑catenin axis.  Molecular Medicine Reports,  28  (3): (1-14).  [PMID:37449526]
67. Xinyan Tao, Yuan Liu, Zhenhua Ding, Shuang Xie, Wenxiong Cao, Xiaohong Li.  (2023)  Injectable cell-targeting fiber rods to promote lipolysis and regulate inflammation for obesity treatment.  Biomaterials Science,      [PMID:37432672]
68. Yawei Kong, Jianpeng Ao, Qiushu Chen, Wenhua Su, Yinping Zhao, Yiyan Fei, Jiong Ma, Minbiao Ji, Lan Mi.  (2023)  Evaluating Differentiation Status of Mesenchymal Stem Cells by Label-Free Microscopy System and Machine Learning.  Cells,  12  (11): (1524).  [PMID:37296645]
69. Gao Rongyin, Zhang Ximei, Zou Kun, Meng Duo, Lv Jinpeng.  (2023)  Cryptochrome 1 activation inhibits melanogenesis and melanosome transport through negative regulation of cAMP/PKA/CREB signaling pathway.  Frontiers in Pharmacology,  14    [PMID:36814484]
70. Xiaoxue Ren, Xiaoting Gao, Yicheng Cheng, Lingxia Xie, Liping Tong, Wei Li, Paul K. Chu, Huaiyu Wang.  (2022)  Maintenance of multipotency of bone marrow mesenchymal stem cells on poly(ε-caprolactone) nanoneedle arrays through the enhancement of cell-cell interaction.  Frontiers in Bioengineering and Biotechnology,  10  (1076345).  [PMID:36698633]
71. Fei He, Chendong Yang, Haoye Liu, Jizeng Wang.  (2023)  Changes in the mechanical properties of human mesenchymal stem cells during differentiation.  Royal Society Open Science,  10  (1):   [PMID:36636310]
72. Xiaoyu Cai, Songxue Wang, Huali Wang, Suwen Liu, Guishan Liu, Huibin Chen, Ji Kang, Hao Wang.  (2023)  Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and vitro.  Food Science and Human Wellness,  12  (1174).  [PMID:]
73. Shuai Chen, Yicheng Jiang, Xiaoyang Qi, Peng Song, Liming Tang, Hanyang Liu.  (2022)  Bioinformatics analysis to obtain critical genes regulated in subcutaneous adipose tissue after bariatric surgery.  Adipocyte,  11  (1): (550-561).  [PMID:36036283]
74. Zhu Shenglong, Zhang Jingwei, Wang Wei, Jiang Xuan, Chen Yong Q..  (2022)  Blockage of NDUFB9-SCD1 pathway inhibits adipogenesis.  JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,  78  (2): (377-388).  [PMID:35122619]
75. Zhu Shenglong, Wang Wei, Zhang Jingwei, Ji Siyu, Jing Zhe, Chen Yong Q..  (2022)  Slc25a5 regulates adipogenesis by modulating ERK signaling in OP9 cells.  CELLULAR & MOLECULAR BIOLOGY LETTERS,  27  (1): (1-13).  [PMID:35109789]
76. Luo M et al..  (2020)  Sanguinarine Rapidly Relaxes Rat Airway Smooth Muscle Cells Dependent on TAS2R Signaling..  Biol Pharm Bull,  43  (7): (1027-1034).  [PMID:32404582]

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