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3-Isobutyl-1-methylxanthine - 99%, high purity , CAS No.28822-58-4, Antagonist of A 1 receptor

  • ≥99%
Item Number
I106812
Grouped product items
SKUSizeAvailabilityPrice Qty
I106812-100mg
100mg
In stock
$54.90
I106812-250mg
250mg
In stock
$86.90
I106812-1g
1g
In stock
$245.90
I106812-5g
5g
In stock
$1,049.90

Non-specific cAMP and cGMP inhibitor

Basic Description

SynonymsIBMX|3-Isobutyl-1-methylxanthine|28822-58-4|isobutylmethylxanthine|Methylisobutylxanthine|1-METHYL-3-ISOBUTYLXANTHINE|1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-|3-Isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione|3-isobutyl-1-methylxanthine
Specifications & Purity99%
Storage TempStore at -20°C
Shipped InDry ice
Action TypeANTAGONIST
Mechanism of actionAntagonist of A 1 receptor
Product Description

Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa (IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction, GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.

Associated Targets

PDE3B Tclin cGMP-inhibited 3',5'-cyclic phosphodiesterase B 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

ADORA1 Tclin Adenosine receptor A1 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione
INCHI InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12)
InChi Key APIXJSLKIYYUKG-UHFFFAOYSA-N
Canonical SMILES CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2
Isomeric SMILES CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2
WGK Germany 3
RTECS ZD8500000
PubChem CID 3758
Molecular Weight 222.24
Beilstein 247859

Certificates

Certificate of Analysis(COA)

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24 results found

Lot NumberCertificate TypeDateItem
G2408564Certificate of AnalysisJun 27, 2024 I106812
G2408563Certificate of AnalysisJun 27, 2024 I106812
G2408562Certificate of AnalysisJun 27, 2024 I106812
I2321591Certificate of AnalysisSep 06, 2023 I106812
I2321542Certificate of AnalysisSep 06, 2023 I106812
I2321541Certificate of AnalysisSep 06, 2023 I106812
I2321540Certificate of AnalysisSep 06, 2023 I106812
I2321523Certificate of AnalysisSep 06, 2023 I106812
I2321522Certificate of AnalysisSep 06, 2023 I106812
F2406088Certificate of AnalysisSep 06, 2023 I106812
I2321736Certificate of AnalysisSep 06, 2023 I106812
I2321749Certificate of AnalysisSep 06, 2023 I106812
E2407058Certificate of AnalysisSep 06, 2023 I106812
D2429037Certificate of AnalysisSep 06, 2023 I106812
K2201521Certificate of AnalysisSep 15, 2022 I106812
K2201527Certificate of AnalysisSep 15, 2022 I106812
K2201529Certificate of AnalysisSep 15, 2022 I106812
K2201548Certificate of AnalysisSep 15, 2022 I106812
F2217136Certificate of AnalysisJun 01, 2022 I106812
F2217116Certificate of AnalysisJun 01, 2022 I106812
F2217114Certificate of AnalysisJun 01, 2022 I106812
F2217109Certificate of AnalysisJun 01, 2022 I106812
B2209108Certificate of AnalysisFeb 11, 2022 I106812
A2219158Certificate of AnalysisFeb 11, 2022 I106812

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Chemical and Physical Properties

Melt Point(°C)200-203°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

Precautionary Statements

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

WGK Germany 3
RTECS ZD8500000

Related Documents

References

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