Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
SKU | Size | Availability | Price | Qty |
---|---|---|---|---|
I423008-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $49.90 |
Non-specific cAMP and cGMP inhibitor
Synonyms | IBMX|3-Isobutyl-1-methylxanthine|28822-58-4|isobutylmethylxanthine|Methylisobutylxanthine|1-METHYL-3-ISOBUTYLXANTHINE|1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-(2-methylpropyl)-|3-Isobutyl-1-methyl-1H-purine-2,6(3H,7H)-dione|3-isobutyl-1-methylxanthine |
---|---|
Specifications & Purity | 10mM in DMSO |
Storage Temp | Store at -80°C |
Shipped In | Dry ice |
Product Description | IBMX is a widely-used non-specific inhibitor of cyclic AMP (cAMP) and cyclic GMP (cGMP) phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX. By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors,typically antagonizing the suppressive effects of natural agonists. |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
---|
IUPAC Name | 1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione |
---|---|
INCHI | InChI=1S/C10H14N4O2/c1-6(2)4-14-8-7(11-5-12-8)9(15)13(3)10(14)16/h5-6H,4H2,1-3H3,(H,11,12) |
InChi Key | APIXJSLKIYYUKG-UHFFFAOYSA-N |
Canonical SMILES | CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2 |
Isomeric SMILES | CC(C)CN1C2=C(C(=O)N(C1=O)C)NC=N2 |
WGK Germany | 3 |
RTECS | ZD8500000 |
PubChem CID | 3758 |
Molecular Weight | 222.24 |
Beilstein | 247859 |
Enter Lot Number to search for COA:
Melt Point(°C) | 200-203°C |
---|
Pictogram(s) | GHS07 |
---|---|
Signal | Warning |
Hazard Statements | H302:Harmful if swallowed |
Precautionary Statements | P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help. |
WGK Germany | 3 |
RTECS | ZD8500000 |