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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | 5-Methyl-1H-pyrazole-3-carboxylic acid | 402-61-9 | 3-methyl-1H-pyrazole-5-carboxylic acid | 696-22-0 | 3-Methylpyrazole-5-carboxylic acid | 5-METHYLPYRAZOLE-3-CARBOXYLIC ACID | 5-Methyl-2H-pyrazole-3-carboxylic acid | AS057278 | 3-METHYL-1H-PYRAZOLE-5-CARBOXYLICACID | 5-m |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | 3-Methylpyrazole-5-carbox?ylic acid is a potent and selective D-amino acid oxidase (DAO) (also known as DAAO, DAMOX and OXDA) inhibitor that protects DAO cells from oxidative stress induced by D-Serine. 3-Methylpyrazole-5-carbox?ylic acid specifically prevents formalin-induced tonic pain. |
Associated Targets(Human)
HCAR2 Tclin Hydroxycarboxylic acid receptor 2 (1 Activities)
DAO Tchem D-amino-acid oxidase (5 Activities)
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KCNH2 Tclin HERG (29587 Activities)
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HCAR3 Tchem HM74 nicotinic acid GPCR (353 Activities)
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DAO Tchem D-amino-acid oxidase (802 Activities)
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DDO Tchem D-aspartate oxidase (120 Activities)
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Associated Targets(non-human)
pol Human immunodeficiency virus type 1 reverse transcriptase (18245 Activities)
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Hcar2 Hydroxycarboxylic acid receptor 2 (55 Activities)
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Mus musculus (284745 Activities)
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Rattus norvegicus (775804 Activities)
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rep Replicase polyprotein 1ab (378 Activities)
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Brain (1 Activities)
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Plasma (328 Activities)
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SARS-CoV-2 (38078 Activities)
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Names and Identifiers
| IUPAC Name | 5-methyl-1H-pyrazole-3-carboxylic acid |
|---|---|
| INCHI | InChI=1S/C5H6N2O2/c1-3-2-4(5(8)9)7-6-3/h2H,1H3,(H,6,7)(H,8,9) |
| InChi Key | WSMQKESQZFQMFW-UHFFFAOYSA-N |
| Canonical SMILES | CC1=CC(=NN1)C(=O)O |
| Isomeric SMILES | CC1=CC(=NN1)C(=O)O |
| WGK Germany | 3 |
| RTECS | UQ6407500 |
| PubChem CID | 9822 |
| Molecular Weight | 126.11 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Melt Point(°C) | 236-240°C |
|---|
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H302+H312+H332:Harmful if swallowed, in contact with skin or if inhaled |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| RTECS | UQ6407500 |
| Merck Index | 6115 |