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3-Phenyl-toxoflavin , CAS No.32502-63-9

CAS#: 32502-63-9
Formula: C₁₃H₁₁N₅O₂
Molecular Weight: 269.26
PubChem CID: 460748

Item Number

P412904

Grouped product items
SKU	Size	Availability	Price	Qty
P412904-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$969.90

Basic Description

Synonyms	1,6-Dimethyl-3-phenylpyrimido[5,4-E][1,2,4]triazine-5,7(1H,6H)-dione # \| Oprea1_364785 \| BDBM36527 \| CCG-144081 \| AKOS000714986 \| MLS-0066984.0001 \| MLS-0066984.0002 \| SCHEMBL2183740 \| SFOMBJIIZPCRJH-UHFFFAOYSA-N \| Pyrimido(5,4-e)-1,2,4-triazine-5,7-(1H,6
Biochemical and Physiological Mechanisms	3-Phenyl-toxoflavin (3-Phenyltoxoflavin), a derivative of Toxoflavin, is an inhibitor of Hsp90 with Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyl-toxoflavin exhibits anti-cancer activity.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Information 3-Phenyl-toxoflavin (3-Phenyltoxoflavin), a derivative of Toxoflavin, is an inhibitor of Hsp90 with Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyl-toxoflavin exhibits anti-cancer activity.

Associated Targets(Human)

TDP2 Tchem Tyrosyl-DNA phosphodiesterase 2 (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDM4C Tchem Lysine-specific demethylase 4C (1 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RAF1 Tclin Serine/threonine-protein kinase RAF (4169 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAP2K1 Tclin Dual specificity mitogen-activated protein kinase kinase 1 (4127 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BT-474 (2113 Activities)

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A549 (127892 Activities)

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HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KDM4C Tchem Lysine-specific demethylase 4C (1129 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SNCA Tchem Alpha-synuclein (10960 Activities)

Discover Target: SNCA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP2 Tchem Tyrosyl-DNA phosphodiesterase 2 (864 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Cruzipain (33337 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

lipdh Dihydrolipoyl dehydrogenase (4 Activities)

Discover Target: lipdh

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Giardia (1682 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

dlaT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (54 Activities)

Discover Target: dlaT

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	1,6-dimethyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
INCHI	InChI=1S/C13H11N5O2/c1-17-12(19)9-11(15-13(17)20)18(2)16-10(14-9)8-6-4-3-5-7-8/h3-7H,1-2H3
InChi Key	SFOMBJIIZPCRJH-UHFFFAOYSA-N
Canonical SMILES	CN1C2=NC(=O)N(C(=O)C2=NC(=N1)C3=CC=CC=C3)C
Isomeric SMILES	CN1C2=NC(=O)N(C(=O)C2=NC(=N1)C3=CC=CC=C3)C
PubChem CID	460748
Molecular Weight	269.26

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3-Phenyl-toxoflavin , CAS No.32502-63-9

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Names and Identifiers

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Certificate of Analysis(COA)

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