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3-Phenyl-toxoflavin , CAS No.32502-63-9

Item Number
P412904
Grouped product items
SKUSizeAvailabilityPrice Qty
P412904-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$969.90

Basic Description

Synonyms32502-63-9|3-Phenyltoxoflavin|1,6-Dimethyl-3-phenylpyrimido[5,4-E][1,2,4]triazine-5,7(1H,6H)-dione|1,6-dimethyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7-dione|Pyrimido[5,4-e]-1,2,4-triazine-5,7(1H,6H)-dione, 1,6-dimethyl-3-phenyl-|P00002|Oprea1_364785|O
Biochemical and Physiological Mechanisms3-Phenyl-toxoflavin (3-Phenyltoxoflavin), a derivative of Toxoflavin, is an inhibitor of Hsp90 with Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyl-toxoflavin exhibits anti-cancer activity.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Information

3-Phenyl-toxoflavin (3-Phenyltoxoflavin), a derivative of Toxoflavin, is an inhibitor of Hsp90 with Kd of 585 nM for the interaction of Hsp90-TPR2A. 3-Phenyl-toxoflavin exhibits anti-cancer activity.

Associated Targets

RAF1 Tclin RAF proto-oncogene serine/threonine-protein kinase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TXNRD1 Tclin Thioredoxin reductase 1, cytoplasmic 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SNCA Tchem Alpha-synuclein 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

SMAD3 Tchem Mothers against decapentaplegic homolog 3 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP2 Tchem Tyrosyl-DNA phosphodiesterase 2 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

KDM4C Tchem Lysine-specific demethylase 4C 1 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

DLAT Tbio Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

MAP2K1 Tclin Dual specificity mitogen-activated protein kinase kinase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name 1,6-dimethyl-3-phenylpyrimido[5,4-e][1,2,4]triazine-5,7-dione
INCHI InChI=1S/C13H11N5O2/c1-17-12(19)9-11(15-13(17)20)18(2)16-10(14-9)8-6-4-3-5-7-8/h3-7H,1-2H3
InChi Key SFOMBJIIZPCRJH-UHFFFAOYSA-N
Canonical SMILES CN1C2=NC(=O)N(C(=O)C2=NC(=N1)C3=CC=CC=C3)C
Isomeric SMILES CN1C2=NC(=O)N(C(=O)C2=NC(=N1)C3=CC=CC=C3)C
PubChem CID 460748
Molecular Weight 269.26

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