Streptosterol is the cholesterol precursor in the Bloch pathway, and 24-dehydrocholesterol reductase plays a catalytic role in this step. The chain sterols accumulate during the depletion of 24-dehydrocholesterol reductase, leading to chain sterolization.
Storage Temp
Store at -20°C
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
AGONIST
Mechanism of action
Agonist of Liver X receptor-α;Agonist of Liver X receptor-β
1.Xu Xing, Chen Jun, Li Yan, Yang Xiaojie, Wang Qing, Wen Yanjun, Yan Ming, Zhang Jianjun, Xu Qin, Wei Yan, Chen Wantao, Wang Xu. (2021) Targeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma. Cell Death & Disease, 12 (5):(1-15). [PMID:33986254][10.1038/s41419-021-03760-2]
References
1.Xu Xing, Chen Jun, Li Yan, Yang Xiaojie, Wang Qing, Wen Yanjun, Yan Ming, Zhang Jianjun, Xu Qin, Wei Yan, Chen Wantao, Wang Xu. (2021) Targeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma. Cell Death & Disease, 12 (5):(1-15). [PMID:33986254][10.1038/s41419-021-03760-2]
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