1.Kapp TG, Rechenmacher F, Neubauer S, Maltsev OV, Cavalcanti-Adam EA, Zarka R, Reuning U, Notni J, Wester HJ, Mas-Moruno C et al.. (2017) A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins.. Sci Rep, 7 (13):(39805). [PMID:28074920][10.1021/op500134e]
2.Sheldrake HM, Patterson LH. (2014) Strategies to inhibit tumor associated integrin receptors: rationale for dual and multi-antagonists.. J Med Chem, 57 (15):(6301-15). [PMID:24568695][10.1021/op500134e]
3.Miller LM, Pritchard JM, Macdonald SJF, Jamieson C, Watson AJB. (2017) Emergence of Small-Molecule Non-RGD-Mimetic Inhibitors for RGD Integrins.. J Med Chem, 60 (8):(3241-3251). [PMID:28135089][10.1021/op500134e]
4.Cirkel GA, Kerklaan BM, Vanhoutte F, Van der Aa A, Lorenzon G, Namour F, Pujuguet P, Darquenne S, de Vos FY, Snijders TJ et al.. (2016) A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies.. Invest New Drugs, 34 (2):(184-92). [PMID:26792581][10.1021/op500134e]
5.Hatley RJD, Macdonald SJF, Slack RJ, Le J, Ludbrook SB, Lukey PT. (2018) An αv-RGD Integrin Inhibitor Toolbox: Drug Discovery Insight, Challenges and Opportunities.. Angew Chem Int Ed Engl, 57 (13):(3298-3321). [PMID:28944552][10.1021/op500134e]
6.Barrett TN, Taylor JA, Barker D, Procopiou PA, Thompson JDF, Barrett J, Le J, Lynn SM, Pogany P, Pratley C et al.. (2019) Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.. J Med Chem, 62 (16):(7543-7556). [PMID:31381331][10.1021/op500134e]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
