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3S,4R-293B , CAS No.S607164, Channel blocker of K v7.1
Basic Description Synonyms 3S,4R-293B | CHEMBL44297 | chromanol 239B | N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide | 163163-25-5 | N-((3S,4R)-6-Cyano-3-hydroxy-2,2-dimethylchroman-4-yl)-N-methylethanesulfonamide | Tocris-1412 | Tocris-1475 | starbld Specifications & Purity Moligand™ Grade Moligand™ Action Type CHANNEL BLOCKER Mechanism of action Channel blocker of K v7.1
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N-[(3S,4R)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamide INCHI InChI=1S/C15H20N2O4S/c1-5-22(19,20)17(4)13-11-8-10(9-16)6-7-12(11)21-15(2,3)14(13)18/h6-8,13-14,18H,5H2,1-4H3/t13-,14+/m1/s1 InChi Key HVSJHHXUORMCGK-KGLIPLIRSA-N Canonical SMILES CCS(=O)(=O)N([C@H]1[C@H](O)C(C)(C)Oc2c1cc(cc2)C#N)C Isomeric SMILES CCS(=O)(=O)N(C)[C@H]1[C@@H](C(OC2=C1C=C(C=C2)C#N)(C)C)O PubChem CID 6604863
References 1. Seebohm G, Lerche C, Pusch M, Steinmeyer K, Brüggemann A, Busch AE. (2001) A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B.. Br J Pharmacol, 134 (8): (1647-54). [PMID:11739240 ] [10.1021/op500134e ]
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