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4′-[[(1-oxopentyl)phenylamino]methyl]-[1,1′-biphenyl]-2-carboxylic acid , CAS No.862891-27-8, Agonist of BLT 2 receptor

CAS#: 862891-27-8
Formula: C₂₅H₂₅NO₃
Molecular Weight: 387.47
PubChem CID: 51529932

Item Number

O353431

Grouped product items
SKU	Size	Availability	Price	Qty
O353431-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$57.90
O353431-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$109.90

a BLT2 agonist

View related series

BLT2 receptor Agonist GPCR/G Protein Leukotriene Receptor

Basic Description

Synonyms	HY-122124 \| CS-0081946 \| 4'-{[Pentanoyl(phenyl)amino]methyl}[1,1'-biphenyl]-2-carboxylic acid \| SCHEMBL3126345 \| 4'-[[(1-oxopentyl)phenylamino]methyl]-[1,1'-biphenyl]-2-carboxylic acid \| DTXSID40680163 \| CHEBI:183836 \| IUJTVDNJFPZYBL-UHFFFAOYSA-N \| Q27075
Specifications & Purity	Moligand™
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of BLT 2 receptor
Product Description	4'-[[(1-oxopentyl)phenylamino]methyl]-[1,1'-biphenyl]-2-carboxylic acid is a selective, potent full agonist for BLT2 (EC\|50\|= 20 nM). It does not displace [3H]-LTB4 binding to BLT1 at concentrations >1 μM and activates BLT2 at significantly lower concentrations than LTB\|4\|(EC\|50\|= 170 nM). 4'-[[(1-oxopentyl)phenylamino]methyl]-[1,1'-biphenyl]-2-carboxylic acid increases intracellular calcium stores in a dose-dependent manner, and induces ERK phosphorylation in Chinese hamster ovary (CHO) cells expressing BLT2 with no effect on CHO cells expressing BLT1.

Associated Targets(Human)

LTB4R2 Tchem Leukotriene B4 receptor 2 (4 Activities)

Discover Target: LTB4R2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LTB4R Tchem Leukotriene B4 receptor 1 (1083 Activities)

Discover Target: LTB4R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LTB4R2 Tchem Leukotriene B4 receptor 2 (146 Activities)

Discover Target: LTB4R2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCT-116 (91556 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	2-[4-[(N-pentanoylanilino)methyl]phenyl]benzoic acid
INCHI	InChI=1S/C25H25NO3/c1-2-3-13-24(27)26(21-9-5-4-6-10-21)18-19-14-16-20(17-15-19)22-11-7-8-12-23(22)25(28)29/h4-12,14-17H,2-3,13,18H2,1H3,(H,28,29)
InChi Key	IUJTVDNJFPZYBL-UHFFFAOYSA-N
Canonical SMILES	CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C(=O)O)C3=CC=CC=C3
Isomeric SMILES	CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C(=O)O)C3=CC=CC=C3
PubChem CID	51529932
Molecular Weight	387.47

CAS Registry No.

862891-27-8

PubChem CID

51529932

GPCRdb Ligand

CAY10583

References

1. Iizuka Y, Yokomizo T, Terawaki K, Komine M, Tamaki K, Shimizu T. (2005) Characterization of a mouse second leukotriene B4 receptor, mBLT2: BLT2-dependent ERK activation and cell migration of primary mouse keratinocytes.. J Biol Chem, 280 (26): (24816-23). [PMID:15866883] [10.1021/op500134e]

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4′-[[(1-oxopentyl)phenylamino]methyl]-[1,1′-biphenyl]-2-carboxylic acid , CAS No.862891-27-8, Agonist of BLT 2 receptor

Basic Description

Associated Targets(Human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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