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4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride - 98%, high purity , CAS No.30827-99-7

  • ≥98%
Item Number
A109762
Grouped product items
SKUSizeAvailabilityPrice Qty
A109762-25mg
25mg
In stock
$15.90
A109762-100mg
100mg
In stock
$39.90
A109762-250mg
250mg
In stock
$66.90
A109762-500mg
500mg
In stock
$92.90
A109762-1g
1g
In stock
$129.90
A109762-5g
5g
In stock
$382.90
A109762-10g
10g
In stock
$612.90
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Broad spectrum, irreversible serine protease inhibitor

View related series
Element classified compounds Protease inhibitors

Basic Description

Synonyms30827-99-7 | 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride | AEBSF HCl | AEBSF | AEBSF hydrochloride | Pefabloc SC | Pefabloc | 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride hydrochloride | AEBSF (hydrochloride) | 4-(2-Aminoethyl)benzenesulphonyl fluoride hydrochlor
Specifications & Purity≥98%
Biochemical and Physiological MechanismsIrreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, impr
Storage TempStore at -20°C,Argon charged
Shipped InIce chest + Ice pads
Product Description

4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) has been used:
as a protease inhibitor in plasma samples to prevent acylated ghrelin (AG) degradation
as a snake venom serine proteinase (SVSP) inhibitor in SVSP inhibition or AEBSF assay to test the involvement of SVSPs on the fibrinogen-clotting activity
as a component in NP-40 lysis buffer to resuspend cell pellets for preparing cell lysates
Recommended concentrations for use are 0.1-1 mM.

Associated Targets(Human)

CTSG Tchem Cathepsin G (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GMNN Tbio Geminin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TMPRSS4 Tbio Transmembrane protease serine 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
POLK Tbio DNA polymerase kappa (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
POLI Tchem DNA polymerase iota (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLG Tclin Plasminogen (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CELA1 Tchem Chymotrypsin-like elastase family member 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Prothrombin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLG Tclin Plasminogen (2339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTSG Tchem Cathepsin G (2304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TMPRSS4 Tbio Transmembrane protease serine 4 (563 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CELA2A Pancreatic elastase (395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488188547
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488188547
IUPAC Name 4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride
INCHI InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChi Key WRDABNWSWOHGMS-UHFFFAOYSA-N
Canonical SMILES C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
Isomeric SMILES C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
WGK Germany 3
PubChem CID 186136
UN Number 3261
Molecular Weight 239.69
Beilstein 7604627
Reaxy-Rn 7604627

Certificates

Certificate of Analysis(COA)

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38 results found

Lot NumberCertificate TypeDateItem
C2419023Certificate of AnalysisMar 08, 2024 A109762
A2423083Certificate of AnalysisJan 17, 2024 A109762
A2423084Certificate of AnalysisJan 17, 2024 A109762
A2423086Certificate of AnalysisJan 17, 2024 A109762
A2423088Certificate of AnalysisJan 17, 2024 A109762
A2423090Certificate of AnalysisJan 17, 2024 A109762
A2423091Certificate of AnalysisJan 17, 2024 A109762
A2423093Certificate of AnalysisJan 17, 2024 A109762
A2423095Certificate of AnalysisJan 17, 2024 A109762
A2423081Certificate of AnalysisJan 17, 2024 A109762
I2313587Certificate of AnalysisJul 11, 2023 A109762
I2313588Certificate of AnalysisJul 11, 2023 A109762
I2313589Certificate of AnalysisJul 11, 2023 A109762
C2329710Certificate of AnalysisMar 16, 2023 A109762
C2329711Certificate of AnalysisMar 16, 2023 A109762
C2329714Certificate of AnalysisMar 16, 2023 A109762
C2330128Certificate of AnalysisMar 16, 2023 A109762
B2308212Certificate of AnalysisJan 31, 2023 A109762
B2308213Certificate of AnalysisJan 31, 2023 A109762
B2308228Certificate of AnalysisJan 31, 2023 A109762
B2308230Certificate of AnalysisJan 31, 2023 A109762
B2308210Certificate of AnalysisJan 31, 2023 A109762
B2308211Certificate of AnalysisJan 31, 2023 A109762
B2308207Certificate of AnalysisJan 31, 2023 A109762
B2308208Certificate of AnalysisJan 31, 2023 A109762
B2308209Certificate of AnalysisJan 31, 2023 A109762
K2211061Certificate of AnalysisNov 02, 2022 A109762
K2211017Certificate of AnalysisNov 02, 2022 A109762
K2211018Certificate of AnalysisNov 02, 2022 A109762
K2211019Certificate of AnalysisNov 02, 2022 A109762
K2211023Certificate of AnalysisNov 02, 2022 A109762
H2217166Certificate of AnalysisJul 08, 2022 A109762
H2217165Certificate of AnalysisJul 08, 2022 A109762
C2211115Certificate of AnalysisFeb 20, 2022 A109762
C2211114Certificate of AnalysisFeb 20, 2022 A109762
C2211112Certificate of AnalysisFeb 20, 2022 A109762
C2211104Certificate of AnalysisFeb 20, 2022 A109762
C2211098Certificate of AnalysisFeb 20, 2022 A109762

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Chemical and Physical Properties

SolubilitySoluble in water 50 mg/mL or 100% ethanol.
SensitivityMoisture Sensitive；Heat sensitive
Melt Point(°C)181-185°C

Safety and Hazards(GHS)

Pictogram(s) GHS05
Signal Danger
Hazard Statements

H314:Causes severe skin burns and eye damage

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P310:Immediately call a POISON CENTER or doctor/physician.

WGK Germany 3
Reaxy-Rn 7604627

Related Documents

 SDS

 Specification Sheet

Alternative Products

  1. 3-Aminobenzenesulfonyl fluoride hydrochloride
    3-Aminobenzenesulfonyl fluoride hydrochloride

    Starting at $138.90

  2. 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride - 10mM in DMSO, used for , CAS No. 30827-99-7, by Aladdin Scientific
    4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
    • 10mM in DMSO

    Starting at $69.90

FAQs and Articles

FAQ
SuFEx: Sulfonyl Fluorides that Participate in the Next Click Reaction
Categories: Technical articles
Frequently asked Questions about inhibitors and antagonists related products（FAQ）
Categories: Technical articles
Tags:
inhibitor FAQ Antagonists Frequently asked questions Instructions
Targeted drug discovery: scarce and inefficient, what is the geometry of its effectiveness?
Categories: Technical articles
Tags:
Targeted drug Drug discovery Discovery origin Target-based drug Phenotype-based drugs

Citations of This Product

1. Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua.  (2023)  A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging.  MOLECULES,  28  (5): (2317).  [PMID:36903562]
2. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang.  (2022)  Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor.  ANALYTICAL CHEMISTRY,  94  (50): (17692–17699).  [PMID:36469707]
3. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang.  (2022)  Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems.  DYES AND PIGMENTS,  198  (109993).  [PMID:]

References

1. Marinea M et al..  (2021)  Soy Protein Pressed Gels: Gelation Mechanism Affects the In Vitro Proteolysis and Bioaccessibility of Added Phenolic Acids..  Foods,  10    [PMID:33450925]
2. Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua.  (2023)  A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging.  MOLECULES,  28  (5): (2317).  [PMID:36903562]
3. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang.  (2022)  Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor.  ANALYTICAL CHEMISTRY,  94  (50): (17692–17699).  [PMID:36469707]
4. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang.  (2022)  Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems.  DYES AND PIGMENTS,  198  (109993).  [PMID:]

Solution Calculators

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