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4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride - 10mM in DMSO, high purity , CAS No.30827-99-7

  • 10mM in DMSO
Item Number
A423184
Grouped product items
SKUSizeAvailabilityPrice Qty
A423184-1ml
1ml
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$69.90
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Broad spectrum, irreversible serine protease inhibitor

Basic Description

Synonyms30827-99-7 | 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride | AEBSF HCl | AEBSF | AEBSF hydrochloride | Pefabloc SC | Pefabloc | 4-(2-Aminoethyl)benzene-1-sulfonyl fluoride hydrochloride | AEBSF (hydrochloride) | 4-(2-Aminoethyl)benzenesulphonyl fluoride hydrochlor
Specifications & Purity10mM in DMSO
Biochemical and Physiological MechanismsIrreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, impr
Storage TempStore at -80°C
Shipped InIce chest + Ice pads
Product Description

Recommended concentrations for use are .1-1 mM.

Associated Targets(Human)

CTSG Tchem Cathepsin G (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
GMNN Tbio Geminin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TMPRSS4 Tbio Transmembrane protease serine 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
POLK Tbio DNA polymerase kappa (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
POLI Tchem DNA polymerase iota (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PLG Tclin Plasminogen (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CELA1 Tchem Chymotrypsin-like elastase family member 1 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Prothrombin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
KCNH2 Tclin Potassium voltage-gated channel subfamily H member 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLG Tclin Plasminogen (2339 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CTSG Tchem Cathepsin G (2304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLK Tbio DNA polymerase kappa (8653 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
POLI Tchem DNA polymerase iota (116820 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GMNN Tbio Geminin (128009 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B1 Tchem Solute carrier organic anion transporter family member 1B1 (2672 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLCO1B3 Tchem Solute carrier organic anion transporter family member 1B3 (2517 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TMPRSS4 Tbio Transmembrane protease serine 4 (563 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CELA2A Pancreatic elastase (395 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 4-(2-aminoethyl)benzenesulfonyl fluoride;hydrochloride
INCHI InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H
InChi Key WRDABNWSWOHGMS-UHFFFAOYSA-N
Canonical SMILES C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
Isomeric SMILES C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
WGK Germany 3
PubChem CID 186136
UN Number 3261
Molecular Weight 239.69
Beilstein 7604627
Reaxy-Rn 7604627

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SensitivityMoisture Sensitive；Heat sensitive
Melt Point(°C)181-185°C

Safety and Hazards(GHS)

Pictogram(s) GHS05
Signal Danger
Hazard Statements

H314:Causes severe skin burns and eye damage

Precautionary Statements

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P310:Immediately call a POISON CENTER or doctor/physician.

WGK Germany 3
Reaxy-Rn 7604627

Related Documents

 SDS

 Specification Sheet

FAQs and Articles

FAQ
SuFEx: Sulfonyl Fluorides that Participate in the Next Click Reaction
Categories: Technical articles

Citations of This Product

1. Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua.  (2023)  A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging.  MOLECULES,  28  (5): (2317).  [PMID:36903562]
2. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang.  (2022)  Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor.  ANALYTICAL CHEMISTRY,  94  (50): (17692–17699).  [PMID:36469707]
3. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang.  (2022)  Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems.  DYES AND PIGMENTS,  198  (109993).  [PMID:]

References

1. Chenglin Li, Sifan Li, Xinsheng Li, Tao Yuan, Jialei Xu, Xixin Gu, Jianli Hua.  (2023)  A Turn-On Lipid Droplet-Targeted Near-Infrared Fluorescent Probe with a Large Stokes Shift for Detection of Intracellular Carboxylesterases and Cell Viability Imaging.  MOLECULES,  28  (5): (2317).  [PMID:36903562]
2. Yi-Xuan Fu, Wu-Yingzheng Guo, Nan Wang, Yi-Jie Dai, Zi-Ye Zhang, Xin-Lin Sun, Wen-Chao Yang, Guang-Fu Yang.  (2022)  Diagnosis of Bacterial Plant Diseases via a Nitroreductase-Activated Fluorescent Sensor.  ANALYTICAL CHEMISTRY,  94  (50): (17692–17699).  [PMID:36469707]
3. Jingmin Zhang, Youmei Peng, Ying Li, Ning Wang, Yuna Chai, Chongzhen Qin, Xinru Wang, Suna Liu, Yubing Zhou, Xiaojian Zhang, Wenda Zhang.  (2022)  Development of a near-infrared fluorescent probe with large Stokes shift for carboxylesterases detection and its application in living systems.  DYES AND PIGMENTS,  198  (109993).  [PMID:]

Solution Calculators

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