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TK:Tyrosine kinase
4-[4-(6-methoxynaphthalen-2-yl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine , CAS No.M609343, Inhibitor of TEK receptor tyrosine kinase

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4-[4-(6-methoxynaphthalen-2-yl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine , CAS No.M609343, Inhibitor of TEK receptor tyrosine kinase

Moligand™

PubChem CID: 23625762

Item Number

M609343

Grouped product items
SKU	Size	Availability	Price	Qty
M609343-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M609343-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

TEK receptor tyrosine kinase Inhibitor

Basic Description

Synonyms	948557-43-5\|Tie2 kinase inhibitor\|Tie2 kinase inhibitor 1\|Tie2 kinase-IN-1\|Tie2-IN-5\|4-(4-(6-methoxynaphthalen-2-yl)-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-5-yl)pyridine\|CHEMBL237352\|4-[4-(6-Methoxy-2-naphthalenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidaz
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of TEK receptor tyrosine kinase

Associated Targets

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TEK Tclin Angiopoietin-1 receptor 1 Activities

Discover Target: TEK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

INCHI	InChI=1S/C26H21N3O2S/c1-31-22-8-5-19-15-21(4-3-20(19)16-22)25-24(17-11-13-27-14-12-17)28-26(29-25)18-6-9-23(10-7-18)32(2)30/h3-16H,1-2H3,(H,28,29)
InChi Key	SINQIEAULQKUPD-UHFFFAOYSA-N
Canonical SMILES	COc1ccc2c(c1)ccc(c2)c1nc([nH]c1c1ccncc1)c1ccc(cc1)S(=O)C
Isomeric SMILES	COC1=CC2=C(C=C1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)S(=O)C)C5=CC=NC=C5
PubChem CID	23625762

Database links

PubChem CID	23625762
ChEMBL Ligand	CHEMBL237352

Certificates

Certificate of Analysis(COA)

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References

1. Semones M, Feng Y, Johnson N, Adams JL, Winkler J, Hansbury M. (2007) Pyridinylimidazole inhibitors of Tie2 kinase.. Bioorg Med Chem Lett, 17 (17): (4756-60). [PMID:17618114]

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