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4-[4-(6-methoxynaphthalen-2-yl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine , CAS No.M609343, Inhibitor of TEK receptor tyrosine kinase
Basic Description Synonyms Tie2 IN 5; Tie2IN5; Tie2 inhibitor 5; Tie2-inhibitor-5; Tie2 kinase inhibitor 5 | NCGC00090707-04 | CS-0019702 | SMR004702865 | CHEBI:91442 | DTXSID60635231 | Tie2 kinase-IN-1 | BDBM50217603 | Tie2 kinase inhibitor 1 | BB 0258870 | FT-0671288 | Tie2 Kinas Specifications & Purity Moligand™ Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of TEK receptor tyrosine kinase
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers INCHI InChI=1S/C26H21N3O2S/c1-31-22-8-5-19-15-21(4-3-20(19)16-22)25-24(17-11-13-27-14-12-17)28-26(29-25)18-6-9-23(10-7-18)32(2)30/h3-16H,1-2H3,(H,28,29) InChi Key SINQIEAULQKUPD-UHFFFAOYSA-N Canonical SMILES COc1ccc2c(c1)ccc(c2)c1nc([nH]c1c1ccncc1)c1ccc(cc1)S(=O)C Isomeric SMILES COC1=CC2=C(C=C1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)S(=O)C)C5=CC=NC=C5 PubChem CID 23625762
References 1. Semones M, Feng Y, Johnson N, Adams JL, Winkler J, Hansbury M. (2007) Pyridinylimidazole inhibitors of Tie2 kinase.. Bioorg Med Chem Lett, 17 (17): (4756-60). [PMID:17618114 ] [10.1021/op500134e ]
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