Basic Description

Synonyms	AS-57619 \| BDBM50025457 \| 4',5-Dihydroxyflavone \| 4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)- \| FT-0636228 \| A867413 \| s9378 \| Oprea1_419278 \| 5-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one \| PD088057 \| ST057730 \| CCG-266994 \| 5,4''''-Dihydroxyf
Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Information 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone inhibits soybean LOX-1 and yeast α-glucosidase .

Associated Targets(Human)

ALOX5 Tclin Arachidonate 5-lipoxygenase (6568 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AR Tclin Androgen Receptor (11781 Activities)

Discover Target: AR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)

Discover Target: PPARG

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PPARA Tclin Peroxisome proliferator-activated receptor alpha (9197 Activities)

Discover Target: PPARA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LCK Tclin Tyrosine-protein kinase LCK (9212 Activities)

Discover Target: LCK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NEU2 Tbio Sialidase 2 (382 Activities)

Discover Target: NEU2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAF1 Tclin Serine/threonine-protein kinase RAF (4169 Activities)

Discover Target: RAF1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FBP1 Tchem Fructose-1,6-bisphosphatase (1199 Activities)

Discover Target: FBP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HPGD Tchem 15-hydroxyprostaglandin dehydrogenase [NAD+] (24926 Activities)

Discover Target: HPGD

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RGS4 Tchem Regulator of G-protein signaling 4 (13867 Activities)

Discover Target: RGS4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)

Discover Target: MEN1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Ppard Peroxisome proliferator-activated receptor delta (358 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapk1 MAP kinase ERK2 (650 Activities)

Discover Target: Mapk1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

LOX1.1 Seed lipoxygenase-1 (463 Activities)

Discover Target: LOX1.1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapt Microtubule-associated protein tau (6 Activities)

Discover Target: Mapt

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ip6k2 Inositol hexakisphosphate kinase 2 (3 Activities)

Discover Target: Ip6k2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	5-hydroxy-2-(4-hydroxyphenyl)chromen-4-one
INCHI	InChI=1S/C15H10O4/c16-10-6-4-9(5-7-10)14-8-12(18)15-11(17)2-1-3-13(15)19-14/h1-8,16-17H
InChi Key	OKRNDQLCMXUCGG-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C2C(=C1)OC(=CC2=O)C3=CC=C(C=C3)O)O
Isomeric SMILES	C1=CC(=C2C(=C1)OC(=CC2=O)C3=CC=C(C=C3)O)O
PubChem CID	165521
Molecular Weight	254.24

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
I2325266	Certificate of Analysis	Aug 18, 2023	D414389
I2325267	Certificate of Analysis	Aug 18, 2023	D414389
I2325268	Certificate of Analysis	Aug 18, 2023	D414389
I2325269	Certificate of Analysis	Aug 18, 2023	D414389

Chemical and Physical Properties

Solubility	Solubility (25°C) In vitro DMSO: 50 mg/mL (196.66 mM);

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Shumiao Yu, Caicai Xu, Tao Tang, Yiyi Zhang, Kokoette Effiong, Jing Hu, Yonghong Bi, Xi Xiao. (2023) Down-regulation of iron/zinc ion transport and toxin synthesis in Microcystis aeruginosa exposed to 5,4′-dihydroxyflavone. JOURNAL OF HAZARDOUS MATERIALS, 460 (132396). [PMID:37672994] [10.1016/j.jhazmat.2023.132396]
2. Shumiao Yu, Chao Li, Caicai Xu, Kokoette Effiong, Xi Xiao. (2019) Understanding the inhibitory mechanism of antialgal allelochemical flavonoids from genetic variations: Photosynthesis, toxin synthesis and nutrient utility. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 177 (18). [PMID:30954008] [10.1016/j.ecoenv.2019.03.097]

References

1. Shumiao Yu, Caicai Xu, Tao Tang, Yiyi Zhang, Kokoette Effiong, Jing Hu, Yonghong Bi, Xi Xiao. (2023) Down-regulation of iron/zinc ion transport and toxin synthesis in Microcystis aeruginosa exposed to 5,4′-dihydroxyflavone. JOURNAL OF HAZARDOUS MATERIALS, 460 (132396). [PMID:37672994] [10.1016/j.jhazmat.2023.132396]
2. Shumiao Yu, Chao Li, Caicai Xu, Kokoette Effiong, Xi Xiao. (2019) Understanding the inhibitory mechanism of antialgal allelochemical flavonoids from genetic variations: Photosynthesis, toxin synthesis and nutrient utility. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 177 (18). [PMID:30954008] [10.1016/j.ecoenv.2019.03.097]

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SKU	Size	Availability	Price	Qty
D414389-1g	1g	In stock	$274.90
D414389-5g	5g	In stock	$1,029.90

4',5-Dihydroxyflavone - 95%, high purity , CAS No.6665-67-4