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4-[6-[4-(4-methylpiperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline , CAS No.M608713, Inhibitor of activin A receptor type 1;Inhibitor of activin A receptor type 1B;Inhibitor of activin A receptor type IL;Inhibitor of bone morphogenetic protein receptor type IA;Inhibitor of bone morphogenetic protein receptor type IB;Inhibitor of transform

Moligand™

PubChem CID: 60182364

Item Number

M608713

Grouped product items
SKU	Size	Availability	Price	Qty
M608713-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,300.90
M608713-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

activin A receptor type 1 Inhibitor activin A receptor type 1B Inhibitor activin A receptor type IL Inhibitor bone morphogenetic protein receptor type IA Inhibitor bone morphogenetic protein receptor type IB Inhibitor transforming growth factor beta receptor 1 Inhibitor

Basic Description

Synonyms	compound 13r
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of activin A receptor type 1;Inhibitor of activin A receptor type 1B;Inhibitor of activin A receptor type IL;Inhibitor of bone morphogenetic protein receptor type IA;Inhibitor of bone morphogenetic protein receptor type IB;Inhibitor of transform

Associated Targets

TGFBR1 Tchem TGF-beta receptor type-1 1 Activities

Discover Target: TGFBR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TGFBR2 Tchem TGF-beta receptor type-2 1 Activities

Discover Target: TGFBR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMPR2 Tchem Bone morphogenetic protein receptor type-2 0 Activities

Discover Target: BMPR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMPR1B Tchem Bone morphogenetic protein receptor type-1B 1 Activities

Discover Target: BMPR1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMPR1A Tchem Bone morphogenetic protein receptor type-1A 1 Activities

Discover Target: BMPR1A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BMP4 Tchem Bone morphogenetic protein 4 0 Activities

Discover Target: BMP4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVR1 Tchem Activin receptor type-1 1 Activities

Discover Target: ACVR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKAB1 Tchem 5'-AMP-activated protein kinase subunit beta-1 0 Activities

Discover Target: PRKAB1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVRL1 Tchem Serine/threonine-protein kinase receptor R3 1 Activities

Discover Target: ACVRL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVR1B Tchem Activin receptor type-1B 1 Activities

Discover Target: ACVR1B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[6-[4-(4-methylpiperazin-1-yl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline
INCHI	InChI=1S/C26H24N6/c1-30-12-14-31(15-13-30)21-8-6-19(7-9-21)20-16-28-26-24(17-29-32(26)18-20)22-10-11-27-25-5-3-2-4-23(22)25/h2-11,16-18H,12-15H2,1H3
InChi Key	XBGWAKUQSRNWMA-UHFFFAOYSA-N
Canonical SMILES	CN1CCN(CC1)c1ccc(cc1)c1cnc2n(c1)ncc2c1ccnc2c1cccc2
Isomeric SMILES	CN1CCN(CC1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3
PubChem CID	60182364

PubChem CID

60182364

ChEMBL Ligand

CHEMBL2385596

References

1. Engers DW, Frist AY, Lindsley CW, Hong CC, Hopkins CR. (2013) Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe.. Bioorg Med Chem Lett, 23 (11): (3248-52). [PMID:23639540]

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