Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A105809-250mg | 250mg | In stock | $69.90 | |
A105809-500mg | 500mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $121.90 | |
A105809-1g | 1g | In stock | $128.90 | |
A105809-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $952.90 |
Selective COX-3 inhibitor
Synonyms | acetaminophen | Paracetamol | 4-Acetamidophenol | 103-90-2 | Tylenol | N-(4-Hydroxyphenyl)acetamide | APAP | Panadol | N-Acetyl-p-aminophenol | 4'-Hydroxyacetanilide | Acetaminofen | Datril | p-Hydroxyacetanilide | p-Acetamidophenol | Algotropyl | Doliprane | Injectapap | Lonarid | Naprinol |
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Specifications & Purity | analytical standard, ≥99.5% |
Biochemical and Physiological Mechanisms | Selective COX-3 inhibitor (IC 50 = 460 μM). NSAID with widely used analgesic and antipyretic effects. Blood-brain barrier permeable. |
Shipped In | Normal |
Grade | analytical standard |
Action Type | INHIBITOR |
Mechanism of action | Vanilloid receptor opener |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 0.5 |
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IUPAC Name | N-(4-hydroxyphenyl)acetamide |
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INCHI | InChI=1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10) |
InChi Key | RZVAJINKPMORJF-UHFFFAOYSA-N |
Canonical SMILES | CC(=O)NC1=CC=C(C=C1)O |
Isomeric SMILES | CC(=O)NC1=CC=C(C=C1)O |
WGK Germany | 1 |
RTECS | AE4200000 |
PubChem CID | 1983 |
Molecular Weight | 151.16 |
Beilstein | 2208089 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
E2421043 | Certificate of Analysis | Jul 31, 2023 | A105809 |
G2328069 | Certificate of Analysis | Jul 31, 2023 | A105809 |
H2309518 | Certificate of Analysis | Jul 31, 2023 | A105809 |
I2301210 | Certificate of Analysis | Jul 31, 2023 | A105809 |
C2412070 | Certificate of Analysis | Jul 29, 2023 | A105809 |
G2327010 | Certificate of Analysis | Jul 29, 2023 | A105809 |
G2214126 | Certificate of Analysis | Jun 29, 2022 | A105809 |
G2214127 | Certificate of Analysis | Jun 29, 2022 | A105809 |
G2214128 | Certificate of Analysis | Jun 29, 2022 | A105809 |
G2214129 | Certificate of Analysis | Jun 29, 2022 | A105809 |
K2201610 | Certificate of Analysis | Jun 29, 2022 | A105809 |
K2224159 | Certificate of Analysis | Jun 29, 2022 | A105809 |
Sensitivity | Light sensitive. |
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Melt Point(°C) | 168-172°C |
Pictogram(s) | GHS08, GHS09, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H412:Harmful to aquatic life with long lasting effects H302:Harmful if swallowed |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. |
WGK Germany | 1 |
RTECS | AE4200000 |
Merck Index | 47 |
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3. Hongwei Luo, Dongli Wang, Yifeng Zeng, Dongqin He, Ganning Zeng, Juan Xu, Xiangliang Pan. (2024) Iron-doped swine bone char as hydrogen peroxide activator for efficient removal of acetaminophen in water. SCIENCE OF THE TOTAL ENVIRONMENT, 912 (168833). [PMID:38036120] |
4. Guang-Rong Wu, Jia-Kun Xu, Li-Juan Sun, Ying-Fu Li, Shu-Qin Gao, Ying-Wu Lin. (2023) Application of engineered heme enzymes based on myoglobin with high peroxidase activity for efficient degradation of various emerging pollutants. Journal of Environmental Chemical Engineering, 11 (17): (111471). [PMID:9751059] |
5. Kehong Dong, Yuxuan Sun, Xintao Gao, Jing Wang, Xiaochen Wu, Chuanlong Guo. (2024) Mixed micelles loaded with hesperidin protect against acetaminophen induced acute liver injury by inhibiting the mtDNA-cGAS-STING pathway. COLLOIDS AND SURFACES B-BIOINTERFACES, 233 (113656). [PMID:37984191] |
6. Fengxia Wang, Xin Feng, Yanting Gao, Xu Ding, Wei Wang, Ji Zhang. (2023) Green Synthesis of PtPdNiFeCu High-Entropy Alloy Nanoparticles for Glucose Detection. ACS Omega, 8 (50): (47773–47780). [PMID:38144105] |
7. Yecheng Lei, Xiao Lei, Anqi Zhu, Shijie Xie, Tiantian Zhang, Chuo Wang, Anning Song, Xiaoming Wang, Guangwen Shu, Xukun Deng. (2023) Ethanol Extract of Rosa rugosa Ameliorates Acetaminophen-Induced Liver Injury via Upregulating Sirt1 and Subsequent Potentiation of LKB1/AMPK/Nrf2 Cascade in Hepatocytes. MOLECULES, 28 (21): (7307). [PMID:37959727] |
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10. Xamxikamar Mamat, Zehong Gao, Longyi Chen. (2023) Zn-Doped Fe3O4 Nanoparticle @ N, S and P Doped Elaeagnus Angustifolia Gum Derived Carbon Hybrid Electrocatalyst: Synthesis, Characterization and Electrochemical Sensing of Acetaminophen. Materials Advances, (27): [PMID:15358154] |
11. Juan Wang, Feilong Yin, Wenjing Tang, Nini Zhang, Liang Li, Shengbiao Zheng, Jing Tang, Jiahao Guo. (2023) Electrochemical detection of acetaminophen and caffeine using Ag nanoparticles doped metal-organic framework (ZIF-67) composites. International Journal of Electrochemical Science, 18 (100334). [PMID:] |
12. Xin Liu, Peng Xu, Zhuoyu Yang, Pengfei Zhu, Jingwei Ma, Qiulai He, Baolin Hou. (2023) Insight into reactive oxygen species and synergistic mechanism in Fenton-like system using Cu(0) and Fe(III) as the activator. Journal of Environmental Chemical Engineering, (110897). [PMID:] |
13. Yiwei Zhang, Yingjie Luo, Jie Tong, Xuesong Liu, Yong Chen, Tengfei Xu. (2023) Machine learning screening based strategy for the synthesis of a molecularly imprinted ionic liquid polymer for specific adsorption of perfluorooctanoic acid. SEPARATION AND PURIFICATION TECHNOLOGY, 327 (124894). [PMID:] |
14. Shuyin Zhang, Jing Zou, Jiawen Li, Yixin Huang, Jianying Wu, Xiaobin Liao, Qingsong Li, Baoling Yuan, Jun Ma. (2023) Strong enhancement on acetaminophen removal in thermal-activated peroxymonosulfate with sodium metaborate: Performance, mechanism, and control of chlorinated by-products formation. SEPARATION AND PURIFICATION TECHNOLOGY, 327 (124910). [PMID:] |
15. Guoqiang Zhao, Jing Zhou, Yanning Tian, Qifeng Chen, Dongmei Mao, Jianchun Zhu, Xing Huang. (2023) Remediation of fomesafen contaminated soil by Bacillus sp. Za: Degradation pathway, community structure and bioenhanced remediation. ENVIRONMENTAL POLLUTION, 336 (122460). [PMID:37634569] |
16. Yun-fei Zhang, Jia-le Gao, Shen-gui Chen, Lei Li, Jian-hui Xu, Dan Li, Yu-feng Liu, Xin Quan, Xin Fu, Ya-zi Xie, Jing-nan Wu, Dan-ying Lin, Ting-ting Zheng. (2023) Advanced electrooxidation of florfenicol using 3D printed Nb2O5/Ti electrodes: Degradation efficiency, dehalogenation performance, and toxicity reduction. CHEMICAL ENGINEERING JOURNAL, 474 (145561). [PMID:] |
17. Xiaoqin Wei, Hao Guo, Mingyue Wang, Zongyan Lu, Zeyun Yang, Lei Sun, Zhiguo Yu, Yinsheng Liu, Wu Yang. (2023) MoS2 embedded triangular silver nanosheets modified MOF-808 as electrochemical sensing platform for highly sensitive simultaneous detection of ACOP and 4-AP. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 676 (132264). [PMID:] |
18. Ziqi Zhu, Yuwei Xue, Ting Zhang, Mingjun Xu, Qian Zhang, Junming Hong. (2023) Applying the carbon vacancy-enhanced catalyst as the surface reactor for peroxymonosulfate activation and efficient Acetaminophen degradation: Performance and mechanism. SEPARATION AND PURIFICATION TECHNOLOGY, 326 (124811). [PMID:] |
19. Yiqing Wang, Shihu Han, Xiaoping Hu, Wenxiong Li, Bing Na, Changqiong Xie, Xiuli Wang. (2023) Benefiting from the multiple effects of ferrocene and cyclotriphosphazene bi-based hierarchical layered nanosheets towards improving fire safety and mechanical properties of epoxy resin. COMPOSITES PART B-ENGINEERING, 264 (110914). [PMID:] |
20. Zhang Yan, Lu Qian, Liu Shasha, Chai Yuanyuan, Dai Mingxin, Deng Zhongkang, Huang Xin, Zhang Luyong, Yu Qinwei, Jiang Zhenzhou. (2023) Psoralen Ameliorates Acetaminophen-Induced Acute Liver Injury by Inhibiting the Enzymatic Activity of CYP2E1. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy, 33 (5): (1060-1071). [PMID:] |
21. Jinjin Zhang, Wenjing Liu, Qi Wang, Jianying Qu. (2023) A Novel Ti3C2/CoNP-NCNTHP Electrochemical Sensor for the Detection of Paracetamol and 4-Aminophenol Simultaneously. JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 170 (7): (77512). [PMID:] |
22. Yin Jie, Zhao Ziming, Huang Jianzheng, Xiao Yang, Rehmutulla Mewlude, Zhang Biqiong, Zhang Zijun, Xiang Ming, Tong Qingyi, Zhang Yonghui. (2023) Single-cell transcriptomics reveals intestinal cell heterogeneity and identifies Ep300 as a potential therapeutic target in mice with acute liver failure. Cell Discovery, 9 (1): (1-23). [PMID:37488127] |
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24. Zongyan Lu, Hao Guo, Xiaoqin Wei, Lei Sun, Zhilan Pan, Bingqing Liu, Yinsheng Liu, Jiaxi Xu, Jiaying Tian, Wu Yang. (2023) A novel electrochemical sensing platform based on covalent organic frameworks/WC/NH2-MWCNT for highly selective determination of acetaminophen and 4-aminophenol. MICROCHEMICAL JOURNAL, 193 (109075). [PMID:] |
25. Qiuqun Liang, Zheng Liu, Chuxin Liang, Guo-Cheng Han, Shufen Zhang, Xiao-Zhen Feng. (2019) Electrochemical Simultaneous Detection of Paracetamol and 4- aminophenol Based on bis-Schiff Base Cobalt Complex. International Journal of Electrochemical Science, 14 (7178). [PMID:] |
26. Zhiming Jiang, Guangyu Li, Mingxiao Zhang. (2017) A Novel Electrochemical Sensor Based on SH-β-cyclodextrin Functionalized Gold Nanoparticles/Reduced-Graphene Oxide Nanohybrids for Ultrasensitive Electrochemical Sensing of Acetaminophen and Ofloxacin. International Journal of Electrochemical Science, 12 (5157). [PMID:] |
27. Zhiqiang Wei, Shaofang Guo, Liuyang Cheng, Ting Li, Yanli Zhang, Hui Yang. (2019) Simultaneous Determination of Acetaminophen and Tyrosine Using Screen-printed Electrochemical Sensor Based on MWCNTs-doped Poly(glycine)/Poly(acrylic acid) Conducting Polymers. International Journal of Electrochemical Science, 14 (6748). [PMID:36864527] |
28. Liangyun Yu, Yingzhuo Shen, Lu Chen, Qi Zhang, Xiaoya Hu, Qin Xu. (2023) Molecularly imprinted ultrasensitive cholesterol photoelectrochemical sensor based on perfluorinated organics functionalization and hollow carbon spheres anchored organic-inorganic perovskite. BIOSENSORS & BIOELECTRONICS, 237 (115496). [PMID:37421798] |
29. Xin Liu, Peng Xu, Pengfei Zhu, Zhuoyu Yang, Ruoxi Wu, Baolin Hou. (2023) Rapid oxidation of acetaminophen with zero-valent copper induced hydrogen peroxide process in presence of ferric ion and chloride ion. CHEMICAL ENGINEERING JOURNAL, 470 (144202). [PMID:] |
30. Qi Yu, Jin Zou, Qihui Xiong, Guanwei Peng, Feng Gao, Guorong Fan, Shangxing Chen, Limin Lu. (2022) Electrochemical Sensor Based on Biochar Decorated with Gold Clusters for Sensitive Determination of Acetaminophen. International Journal of Electrochemical Science, 17 (220438). [PMID:] |
31. Yong Wang, Xiao Cheng, Chenchen Wang, Duoduo Zhang, Anran Liu, Zhi Wang, Wei Wei, Songqin Liu. (2023) Ag+-gated peroxidase activity of gold nanoparticles for sensitive detection of Escherichia coli. TALANTA, 264 (124779). [PMID:37311328] |
32. Wei Ran, Qinghui Li, Xinlong Hu, De Zhang, Zhi Yu, Yuqiong Chen, Mingle Wang, Dejiang Ni. (2023) Comprehensive analysis of environmental factors on the quality of tea (Camellia sinensis var. sinensis) fresh leaves. SCIENTIA HORTICULTURAE, 319 (112177). [PMID:] |
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34. Dezhen Kong, Yumeng Zhao, Hongdi Guo, Mei Han, Xinru Fan, Jinkuo Li, Xu He, Jun Ma. (2023) Unveiling the Direct Electron Transfer Regime of Peracetic Acid Activation: Quantitative Structure–Activity Relationship Analysis of Carbon Nanotube Catalysis. ACS ES&T Engineering, 3 (7): (1030–1041). [PMID:] |
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