K2219015Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Basic Description
| Synonyms | 4-Aminonaphthalimide | 6-Amino-1H-benzo[de]isoquinoline-1,3(2H)-dione | EINECS 217-110-1 | NCGC00093577-02 | NCGC00015035-08 | 6-Amino-1H-benz(de)isoquinoline-1,3(2H)-dione | 6-Amino-1H-benzo[de]isoquinoline-1,3(2H)-dione # | HMS1791H12 | Lopac-A-0966 | N |
|---|---|
| Specifications & Purity | ≥95% |
| Biochemical and Physiological Mechanisms | 4-amino-1,8-naphthalimide made cells sensitive to radiation-induced cell damage and enhanced the cytotoxicity of 1-methyl-3-nitro-1-nitrosoguanidine.Selective PARP-1 inhibitor (IC 50 = 0.18 μM). Sensitizes cells to chemical and radiation induced cytotoxic |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Associated Targets(Human)
CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)
PARP1 Tclin Poly [ADP-ribose] polymerase 1 (2 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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PDE5A Tclin Phosphodiesterase 5A (5113 Activities)
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EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)
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CA2 Tclin Carbonic anhydrase II (17698 Activities)
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ESR1 Tclin Estrogen receptor alpha (17718 Activities)
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HMGCR Tclin HMG-CoA reductase (2475 Activities)
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NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
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INSR Tclin Insulin receptor (5558 Activities)
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PGR Tclin Progesterone receptor (8562 Activities)
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ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
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ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
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AR Tclin Androgen Receptor (11781 Activities)
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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
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ACE Tclin Angiotensin-converting enzyme (1423 Activities)
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DRD2 Tclin Dopamine D2 receptor (23596 Activities)
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MAOA Tclin Monoamine oxidase A (11911 Activities)
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CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
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DRD1 Tclin Dopamine D1 receptor (9720 Activities)
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DRD4 Tchem Dopamine D4 receptor (7907 Activities)
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ACHE Tclin Acetylcholinesterase (18204 Activities)
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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
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HRH2 Tclin Histamine H2 receptor (5428 Activities)
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ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)
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HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)
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HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
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HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
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ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
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CALCR Tclin Calcitonin receptor (2215 Activities)
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SLC6A4 Tclin Serotonin transporter (12625 Activities)
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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
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PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
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HRH1 Tclin Histamine H1 receptor (7573 Activities)
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ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)
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OPRM1 Tclin Mu opioid receptor (19785 Activities)
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DRD3 Tclin Dopamine D3 receptor (14368 Activities)
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AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
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OPRD1 Tclin Delta opioid receptor (15096 Activities)
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OPRK1 Tclin Kappa opioid receptor (16155 Activities)
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SLC6A3 Tclin Dopamine transporter (10535 Activities)
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KCNH2 Tclin HERG (29587 Activities)
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HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 Activities)
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ESR2 Tclin Estrogen receptor beta (9272 Activities)
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CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)
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ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)
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CHRM4 Tclin Muscarinic acetylcholine receptor M4 (6041 Activities)
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CHRM5 Tclin Muscarinic acetylcholine receptor M5 (4677 Activities)
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ADRA2B Tclin Alpha-2b adrenergic receptor (4412 Activities)
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Associated Targets(non-human)
Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)
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Mc4r Melanocortin receptor 4 (1205 Activities)
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Ltc4s Leukotriene C4 synthase (1 Activities)
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Sigmar1 Sigma opioid receptor (160 Activities)
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Npy1r Neuropeptide Y receptor type 1 (8 Activities)
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Cckar Cholecystokinin A receptor (90 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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polC DNA polymerase III (243 Activities)
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Nos2 Nitric oxide synthase, inducible (3573 Activities)
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Mapk1 MAP kinase ERK2 (650 Activities)
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Mmp9 Matrix metalloproteinase 9 (38 Activities)
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Plasmodium falciparum (966862 Activities)
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Npsr1 Neuropeptide S receptor (260 Activities)
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pfk 6-phospho-1-fructokinase (7870 Activities)
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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)
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Mapt Microtubule-associated protein tau (6 Activities)
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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
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ffp 4'-phosphopantetheinyl transferase ffp (24982 Activities)
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FTL Ferritin light chain (43324 Activities)
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Glra2 Glycine receptor (1745 Activities)
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 6-aminobenzo[de]isoquinoline-1,3-dione |
|---|---|
| INCHI | InChI=1S/C12H8N2O2/c13-9-5-4-8-10-6(9)2-1-3-7(10)11(15)14-12(8)16/h1-5H,13H2,(H,14,15,16) |
| InChi Key | SSMIFVHARFVINF-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC2=C(C=CC3=C2C(=C1)C(=O)NC3=O)N |
| Isomeric SMILES | C1=CC2=C(C=CC3=C2C(=C1)C(=O)NC3=O)N |
| PubChem CID | 1720 |
| Molecular Weight | 212.2 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Chemical and Physical Properties
| Solubility | Soluble in DMSO |
|---|---|
| Melt Point(°C) | >360℃ |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H317:May cause an allergic skin reaction |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |