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4-Aminobenzohydrazide - >98.0%(HPLC), high purity , CAS No.5351-17-7

3 Citations

≥98%(HPLC)

CAS#: 5351-17-7
Formula: C₇H₉N₃O
Molecular Weight: 151.17
Beilstein Registry Number: 14(3)1081
MDL number: MFCD00007606
PubChem CID: 21450
PubChem SID: 488182697

Item Number

A151536

Grouped product items
SKU	Size	Availability	Price
A151536-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$9.90
A151536-5g	5g	Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks.	$13.90
A151536-25g	25g	Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks.	$51.90
A151536-100g	100g	In stock	$152.90
A151536-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$684.90

Potent, irreversible and specific MPO inhibitor

View related series

Glutathione Peroxidase Hydrazide Metabolic Enzyme/Protease Non heterocyclic block

Basic Description

Synonyms	p-Aminobenzoyl hydrazide \| HY-B0880 \| STK075152 \| Z57199627 \| BB 0259293 \| AS-57471 \| EN300-18128 \| para-Aminobenzhydrazide \| SCHEMBL328628 \| 4-Aminobenzoic hydrazide \| BRN 0639053 \| SY036768 \| p-Aminobenzoic hydrazide \| 4NPhCON2 \| AKOS000119698 \| A1211 \|
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Potent, irreversible and specific MPO inhibitor (IC 50 = 300 nM). Benzoic acid analog. No inhibition of catalase or glutathione peroxidase activity. Inhibits apoptosis in vitro .
Storage Temp	Argon charged
Shipped In	Normal
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Associated Targets(Human)

MPO Tchem Myeloperoxidase (2 Activities)

Discover Target: MPO

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MPO Tchem Myeloperoxidase (1002 Activities)

Discover Target: MPO

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Mycobacterium tuberculosis (203094 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488182697
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488182697
IUPAC Name	4-aminobenzohydrazide
INCHI	InChI=1S/C7H9N3O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,8-9H2,(H,10,11)
InChi Key	WPBZMCGPFHZRHJ-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1C(=O)NN)N
Isomeric SMILES	C1=CC(=CC=C1C(=O)NN)N
WGK Germany	3
RTECS	DG2580000
PubChem CID	21450
Molecular Weight	151.17
Beilstein	14(3)1081
Reaxy-Rn	639053

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
K2230126	Certificate of Analysis	Dec 07, 2022	A151536
H2324288	Certificate of Analysis	Aug 27, 2022	A151536
I2224007	Certificate of Analysis	Aug 27, 2022	A151536
I2224008	Certificate of Analysis	Aug 27, 2022	A151536
I2224009	Certificate of Analysis	Aug 27, 2022	A151536
I2224010	Certificate of Analysis	Aug 27, 2022	A151536
C2330278	Certificate of Analysis	Apr 15, 2021	A151536

Chemical and Physical Properties

Solubility	Soluble in DMSO (10 mg/ml), dilute acids, and water (partly miscible).
Sensitivity	air sensitive
Melt Point(°C)	228 °C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	DG2580000
Reaxy-Rn	639053

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Yan Zhao, Xinquan Yu, Xiao Liu, Dailiang Zhang, He Li, Hanlin Zhou, Weiheng Kong, Fengli Qu. (2023) ClO– Induced Dual-Excitation Fluorescent Probes Responding to Diverse Testing Modes with Ratio Methodology. ANALYTICAL CHEMISTRY, 95 (18): (7170–7177). [PMID:37114482] [10.1021/acs.analchem.2c05532]
2. Zhilan Pan, Yuli Wei, Hao Guo, Bingqing Liu, Lei Sun, Zongyan Lu, Xiaoqin Wei, Hao Zhang, Yuan Chen, Wu Yang. (2023) Sensitive detection of sulfamethoxazole by an electrochemical sensing platform with a covalent organic framework in situ grown on polyaniline. MICROPOROUS AND MESOPOROUS MATERIALS, 348 (112409). [PMID:] [10.1016/j.micromeso.2022.112409]
3. Haimei Yang, Qianghong Zhao, Xian Wang, Yu Wu, Yuchen Su, Weili Wei. (2021) Facile and highly selective sensing of hypochlorous acid in aqueous solution and living cells by using as-prepared WSe2 quantum dots. SENSORS AND ACTUATORS B-CHEMICAL, 337 (129782). [PMID:] [10.1016/j.snb.2021.129782]

References

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26. Yuan-Yuan Zhang,Xiang-Zhu Chen,Xing-Yue Liu,Xue-Yan Zhang,Gui Gao,Shi-Cong Hou,Hong-Mei Wang. (2019-07-31) A highly selective and ultrafast near-infrared fluorescent turn-on and colorimetric probe for hypochlorite in living cells.. Analytica chimica acta, 1078 (135-141). [PMID:31358211]
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50. Tirthankar Mohanty,Jane Fisher,Anahita Bakochi,Ariane Neumann,José Francisco Pereira Cardoso,Christofer A Q Karlsson,Chiara Pavan,Iben Lundgaard,Bo Nilson,Peter Reinstrup,Johan Bonnevier,David Cederberg,Johan Malmström,Peter Bentzer,Adam Linder. (2019-04-12) Neutrophil extracellular traps in the central nervous system hinder bacterial clearance during pneumococcal meningitis.. Nature communications, 10 ((1)): (1667-1667). [PMID:30971685]
51. Renfa Liu,Jie Tang,Yunxue Xu,Zhifei Dai. (2019-05-07) Bioluminescence Imaging of Inflammation in Vivo Based on Bioluminescence and Fluorescence Resonance Energy Transfer Using Nanobubble Ultrasound Contrast Agent.. ACS nano, 13 ((5)): (5124-5132). [PMID:31059237]
52. Cuihua Wang,Benjamin Pulli,Negin Jalali Motlagh,Anning Li,Gregory R Wojtkiewicz,Stephan P Schmidt,Yue Wu,Matthias W G Zeller,John W Chen. (2019-11-07) A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales.. Theranostics, 9 ((25)): (7525-7536). [PMID:31695784]
53. Yan Zhao, Xinquan Yu, Xiao Liu, Dailiang Zhang, He Li, Hanlin Zhou, Weiheng Kong, Fengli Qu. (2023) ClO– Induced Dual-Excitation Fluorescent Probes Responding to Diverse Testing Modes with Ratio Methodology. ANALYTICAL CHEMISTRY, 95 (18): (7170–7177). [PMID:37114482] [10.1021/acs.analchem.2c05532]
54. Zhilan Pan, Yuli Wei, Hao Guo, Bingqing Liu, Lei Sun, Zongyan Lu, Xiaoqin Wei, Hao Zhang, Yuan Chen, Wu Yang. (2023) Sensitive detection of sulfamethoxazole by an electrochemical sensing platform with a covalent organic framework in situ grown on polyaniline. MICROPOROUS AND MESOPOROUS MATERIALS, 348 (112409). [PMID:] [10.1016/j.micromeso.2022.112409]
55. Haimei Yang, Qianghong Zhao, Xian Wang, Yu Wu, Yuchen Su, Weili Wei. (2021) Facile and highly selective sensing of hypochlorous acid in aqueous solution and living cells by using as-prepared WSe2 quantum dots. SENSORS AND ACTUATORS B-CHEMICAL, 337 (129782). [PMID:] [10.1016/j.snb.2021.129782]

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