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4-Aminosalicylic acid - 98%, high purity , Dihydrofolate reductase inhibitor, CAS No.65-49-6, Dihydrofolate reductase inhibitor

9 Citations

≥98%

CAS#: 65-49-6
Formula: C₇H₇NO₃
Molecular Weight: 153.14
Beilstein Registry Number: 473071
EC Number: 200-613-5
MDL number: MFCD00007789
PubChem CID: 4649
PubChem SID: 488179842

Item Number

A105007

Grouped product items
SKU	Size	Availability	Price
A105007-25g	25g	In stock	$37.90
A105007-100g	100g	In stock	$133.90
A105007-250g	250g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$300.90
A105007-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$540.90

Competitive pteridine synthetase inhibitor

View related series

Chemical Biology Peptide chemistry

Basic Description

Synonyms	2-Hydroxy-4-aminobenzoic acid \| 4-Asa \| Osacyl \| PAS-C \| WLN: ZR CQ DVQ \| Benzoic acid, 4-aminohydroxy- \| Granupas \| KBioSS_000422 \| BRN 0473071 \| Pamisyl (TN) \| Apacil \| Spectrum_000042 \| 4-14-00-01967 (Beilstein Handbook Reference) \| MLS000069418 \| p-am
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Competitive pteridine synthetase inhibitor. Shows antituberculosis activity. Inhibits NF-κB and folic acid synthesis. Orally active.
Storage Temp	Argon charged
Shipped In	Normal
Action Type	INHIBITOR
Mechanism of action	Dihydrofolate reductase inhibitor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	4-Aminosalicylic acid is an inhibitor of NF κ B. A antibacterial capable of inhibiting the growth of Mycobacterium tuberculosis

Product Properties

ALogP	1.3

Associated Targets(non-human)

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

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Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Cckar Cholecystokinin A receptor (90 Activities)

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Pde4d Phosphodiesterase 4D (4 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Mmp2 Matrix metalloproteinase-2 (12 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Ptpn1 Protein-tyrosine phosphatase 1B (270 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Micrococcus luteus (7463 Activities)

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Staphylococcus aureus (210822 Activities)

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Escherichia coli (133304 Activities)

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Corynebacterium xerosis (106 Activities)

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Mycobacterium avium (4587 Activities)

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Mycobacterium kansasii (6484 Activities)

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Mycobacterium tuberculosis (203094 Activities)

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Pneumocystis carinii (749 Activities)

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Bacillus cereus (7522 Activities)

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Mycolicibacterium smegmatis (8003 Activities)

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Leishmania infantum (5912 Activities)

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Trypanosoma brucei (78846 Activities)

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Trypanosoma brucei brucei (13300 Activities)

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Entamoeba histolytica (2676 Activities)

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Cryptosporidium parvum (1150 Activities)

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Plasmodium falciparum (966862 Activities)

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Leishmania amazonensis (3813 Activities)

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Leishmania donovani (89745 Activities)

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Leishmania major (2877 Activities)

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Leishmania mexicana (936 Activities)

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Trypanosoma cruzi (99888 Activities)

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Trichomonas vaginalis (2376 Activities)

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Toxoplasma gondii (4585 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Trypanosoma brucei rhodesiense (7991 Activities)

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lef Anthrax lethal factor (7585 Activities)

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Corynebacterium pseudodiphtheriticum (105 Activities)

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Mycolicibacter terrae (137 Activities)

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Colon (26 Activities)

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Stomach (551 Activities)

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TGR Thioredoxin glutathione reductase (28579 Activities)

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Mapt Microtubule-associated protein tau (6 Activities)

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Small intestine (70 Activities)

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Glra2 Glycine receptor (1745 Activities)

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Names and Identifiers

Pubchem Sid	488179842
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488179842
IUPAC Name	4-amino-2-hydroxybenzoic acid
INCHI	InChI=1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)
InChi Key	WUBBRNOQWQTFEX-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=C(C=C1N)O)C(=O)O
Isomeric SMILES	C1=CC(=C(C=C1N)O)C(=O)O
WGK Germany	2
RTECS	VO1225000
PubChem CID	4649
Molecular Weight	153.14
Beilstein	473071
Reaxy-Rn	473071

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

15 results found

Lot Number	Certificate Type	Date	Item
K2308218	Certificate of Analysis	Aug 22, 2024	A105007
D2310208	Certificate of Analysis	Jan 22, 2024	A105007
B2309077	Certificate of Analysis	Dec 21, 2023	A105007
H2301214	Certificate of Analysis	Jul 13, 2023	A105007
I2221067	Certificate of Analysis	Jul 13, 2023	A105007
I2221068	Certificate of Analysis	Jul 13, 2023	A105007
I2221069	Certificate of Analysis	Jul 13, 2023	A105007
I2221106	Certificate of Analysis	Jul 13, 2023	A105007
I2301214	Certificate of Analysis	Jul 13, 2023	A105007
D2022075	Certificate of Analysis	Jun 07, 2023	A105007
A2417112	Certificate of Analysis	Sep 05, 2022	A105007
I2221065	Certificate of Analysis	Sep 05, 2022	A105007
H2109041	Certificate of Analysis	Jun 09, 2022	A105007
H2109042	Certificate of Analysis	Jun 09, 2022	A105007
H2109067	Certificate of Analysis	Jun 09, 2022	A105007

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Chemical and Physical Properties

Solubility	Soluble in water (2 g/l) at 20 °C, dilute sodium hydroxide, dilute nitric acid, ether (slightly), methanol, acetone, and ethanol (1 G SOL IN 21 ML ALC). Virtually insoluble in benzene, chloroform, and carbon tetrachloride
Sensitivity	Light and Air sensitive
Melt Point(°C)	150-151°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	2
RTECS	VO1225000
Reaxy-Rn	473071
Merck Index	477

Citations of This Product

1. Yuan Gao, Yun Luo, Zhao Pan, Zhu Zeng, Wenxia Fan, Jingyu Hu, Zhong Zhang, Jinxing Ma, Yang Zhou, Jun Ma. (2024) Comparative study of Fe(II)/sulfite, Fe(II)/PDS and Fe(II)/PMS for p-arsanilic acid treatment: Efficient organic arsenic degradation and contrasting total arsenic removal. WATER RESEARCH, 249 (18): (120967). [PMID:38070343]
2. Qingxin Yang, Ying Liu, Fengniu Lu, Junqi Cheng, Siyuan Sun, Zhiqin Yuan, Chao Lu. (2024) Dopamine-based selective spectrophotometry p-aminosalicylic acid assay by hydrolyzate-triggered formation of azamonardine-like products. ANALYTICA CHIMICA ACTA, 1287 (17): (342059). [PMID:38182367]
3. Qiuyan Zhao, Mingyue Ding, Dangshuai Pei, Xiuhua Qi, Yexuan Mao, Xianqing Huang, Lianjun Song, Jingnan Zuo, Huijuan Yang, Xiya Zhang. (2023) Development of a monoclonal antibody-based lateral flow immunoassay for the detection of benzoic acid in liquid food. Analytical Methods, 15 (45): (6229-6238). [PMID:37943077]
4. Zhiyong Zheng, Yuehua Deng, Weining Xie, Sirui Chen, Xiaoxiao Liang, Shiyuan Liu, Yanbin Jiang, Huaiyu Yang. (2023) Co-Former Screening Method for Multicomponent Crystals Based on Partial Least Squares Regression: A Case Study of Ciprofloxacin. CRYSTAL GROWTH & DESIGN, 23 (5): (3244–3257). [PMID:]
5. Yanghe Liu, Quan Li, Shenghuan Wang, Mengzhu Liang, Yanhong Ji, Zhenyu Cui, Mohammad Younas, Jianxin Li, Benqiao He. (2023) A nanofiltration membrane with positively and negatively charged groups by grafted p-aminosalicylic acid-Fe(III) chelation for Li+/Mg2+ efficient separation. SEPARATION AND PURIFICATION TECHNOLOGY, 308 (122968). [PMID:]
6. Wen Liu, Jinyao Li, Zicheng Wang, Yafei Tian, Guodong Ren, Xiaoyu Hou, Lixia Guo, Lihong Li, Chengwu Zhang, Zhifang Wu, Lili Yan, Sijin Li, Haipeng Diao. (2022) Construction of mitochondria targeted and FRET based ratiometric sensing nanoplatform for sulfur dioxide accurate detection in vitro and in vivo. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 283 (121731). [PMID:36007349]
7. Guodong Ren, ZiCheng Wang, Yafei Tian, Jinyao Li, Yingyu Ma, Liang Zhou, Chengwu Zhang, Lixia Guo, Haipeng Diao, Lihong Li, Li Lu, Sufang Ma, Zhifang Wu, Lili Yan, Wen Liu. (2022) Targeted chemo-photodynamic therapy toward esophageal cancer by GSH-sensitive theranostic nanoplatform. BIOMEDICINE & PHARMACOTHERAPY, 153 (113506). [PMID:36076595]
8. Yuehua Deng, Yuchen Chen, Fang Xie, Jingwen Tang, Rui Zhang, Huaiyu Yang, Yanbin Jiang, Shiyuan Liu. (2022) Minoxidil Multi-Component Crystals with Aromatic Carboxylic Acids: Theoretical Calculation and Structural Analysis. CRYSTAL GROWTH & DESIGN, 22 (6): (3941–3953). [PMID:]
9. Evgeniya V Polyakova,Olga V Shuvaeva,Olga S Koshcheeva,Yuliya E Tyutereva,Ivan P Pozdnyakov. (2020-11-14) Capillary zone electrophoresis as a simple approach for the study of p-arsanilic acid transformation in the process of photolytic degradation.. Electrophoresis, 42 ((6)): (719-724). [PMID:33185273]

References

1. Jie Zhang,Yuanyuan Shan,Xiaoyan Pan,Chen Wang,Wenfang Xu,Langchong He. (2011-07-15) Molecular docking, 3D-QSAR studies, and in silico ADME prediction of p-aminosalicylic acid derivatives as neuraminidase inhibitors.. Chemical biology & drug design, 78 ((4)): (709-717). [PMID:21752201]
2. S M Vesenbeckh,J Becker,C Huhnt,B Karras,T T Bauer,H Mauch,H Rüssmann,N Schönfeld. (2011-08-13) Successful oral desensitization to i.v. para-aminosalicylic acid (PAS) using encapsulated PAS dry substance.. Infection, 40 ((2)): (199-202). [PMID:21833615]
3. Cezary Chojnacki,Ewa Walecka-Kapica,Grazyna Klupinska,Monika Pawłowicz,Antoni Florkowski,Patrycja Wachowska-Kelly,Jan Chojnacki. (2011-09-23) [Evaluation of the influence of tianeptine on the psychosomatic status of patients with ulcerative colitis in remission].. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 31 ((182)): (92-96). [PMID:21936344]
4. Amanda S Fivian-Hughes,Joanna Houghton,Elaine O Davis. (2011-10-29) Mycobacterium tuberculosis thymidylate synthase gene thyX is essential and potentially bifunctional, while thyA deletion confers resistance to p-aminosalicylic acid.. Microbiology (Reading, England), 158 ((Pt 2)): (308-318). [PMID:22034487]
5. A P Marreilha Dos Santos,Rui L Lucas,Vanda Andrade,M Luísa Mateus,Dejan Milatovic,Michael Aschner,M Camila Batoreu. (2011-12-20) Protective effects of ebselen (Ebs) and para-aminosalicylic acid (PAS) against manganese (Mn)-induced neurotoxicity.. Toxicology and applied pharmacology, 258 ((3)): (394-402). [PMID:22178737]
6. Wei-Ping Qin,Tian-Jia Liang,Yue-Ming Jiang. (2012-02-18) [A chronic moderate manganism poisoning treated with sodium p-aminosalicylic acid].. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 29 ((8)): (619-620). [PMID:22335167]
7. Gaurav Vadnerkar,Suneela Dhaneshwar. (2012-06-26) Macromolecular prodrug of 4-aminosalicylic acid for targeted delivery to inflamed colon.. Current drug discovery technologies, 10 ((1)): (16-24). [PMID:22725691]
8. Sumit Chakraborty,Todd Gruber,Clifton E Barry,Helena I Boshoff,Kyu Y Rhee. (2012-11-03) Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis.. Science (New York, N.Y.), 339 ((6115)): (88-91). [PMID:23118010]
9. Dinamene Santos,M Camila Batoreu,Michael Aschner,Ana P Marreilha dos Santos. (2013-01-15) Comparison between 5-aminosalicylic acid (5-ASA) and para-aminosalicylic acid (4-PAS) as potential protectors against Mn-induced neurotoxicity.. Biological trace element research, 152 ((1)): (113-116). [PMID:23315311]
10. Kristin N Adams,John D Szumowski,Lalita Ramakrishnan. (2014-02-18) Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs.. The Journal of infectious diseases, 210 ((3)): (456-466). [PMID:24532601]
11. Guan Liu,Gui-Rong Wang,Xia Yu,Qian Liang,Jing Mu,Yuan-Yuan Shang,Ying Ling,Hai-Qing Zhang,Su-Hua Zheng,Hai-Rong Huang. (2014-05-27) Bacteriological characterization of a Mycobacterium parascrofulaceum strain isolated from a Chinese pneumonia patient.. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 25 (82-87). [PMID:24858903]
12. Hyo-Ji Kim,Kyung-Ah Seo,Hyun-Mi Kim,Eun-Sook Jeong,Jong Lyul Ghim,Seung Heon Lee,Young Min Lee,Dong Hyun Kim,Jae-Gook Shin. (2014-09-15) Simple and accurate quantitative analysis of 20 anti-tuberculosis drugs in human plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry.. Journal of pharmaceutical and biomedical analysis, 102 (9-16). [PMID:25218029]
13. Caihong Huang,He Wang,Juxin Pan,Dan Zhou,Wensheng Chen,Wei Li,Yongxiong Chen,Zuguo Liu. (2014-11-20) Benzalkonium chloride induces subconjunctival fibrosis through the COX-2-modulated activation of a TGF-β1/Smad3 signaling pathway.. Investigative ophthalmology & visual science, 55 ((12)): (8111-8122). [PMID:25406285]
14. Luciana N García,Carolina Leimgruber,Elisa M Uribe Echevarría,Patricio L Acosta,Jorge M Brahamian,Fernando P Polack,María S Miró,Amado A Quintar,Claudia E Sotomayor,Cristina A Maldonado. (2014-12-17) Protective phenotypes of club cells and alveolar macrophages are favored as part of endotoxin-mediated prevention of asthma.. Experimental biology and medicine (Maywood, N.J.), 240 ((7)): (904-916). [PMID:25504013]
15. Min-Jung Park,Seung-Ki Kwok,Sung-Hee Lee,Eun-Kyung Kim,Sung-Hwan Park,Mi-La Cho. (2014-12-17) Adipose tissue-derived mesenchymal stem cells induce expansion of interleukin-10-producing regulatory B cells and ameliorate autoimmunity in a murine model of systemic lupus erythematosus.. Cell transplantation, 24 ((11)): (2367-2377). [PMID:25506685]
16. P Priscilla Lui. (2014-12-22) Intergenerational cultural conflict, mental health, and educational outcomes among Asian and Latino/a Americans: Qualitative and meta-analytic review.. Psychological bulletin, 141 ((2)): (404-446). [PMID:25528344]
17. Maria João Forjaz,Alba Ayala,Pablo Martinez-Martin,Kathy Dujardin,Gregory M Pontone,Sergio E Starkstein,Daniel Weintraub,Albert F G Leentjens. (2014-12-30) Is the Parkinson Anxiety Scale comparable across raters?. Movement disorders : official journal of the Movement Disorder Society, 30 ((4)): (545-551). [PMID:25546697]
18. Carolin Hartmann,Ann-Kathrin Behrendt,Stefanie Henken,Florian Wölbeling,Ulrich A Maus,Gesine Hansen. (2015-01-13) Pneumococcal pneumonia suppresses allergy development but preserves respiratory tolerance in mice.. Immunology letters, 164 ((1)): (44-52). [PMID:25576460]
19. Murad Alturkustani,Julia Keith,Lili-Naz Hazrati,Rosa Rademakers,Lee-Cyn Ang. (2015-02-11) Pathologic staging of white matter lesions in adult-onset leukoencephalopathy/leukodystrophy with axonal spheroids.. Journal of neuropathology and experimental neurology, 74 ((3)): (233-240). [PMID:25668567]
20. Antonella Afeltra,Antonietta Gigante,Domenico Paolo Emanuele Margiotta,Chiara Taffon,Rosario Cianci,Biagio Barbano,Marta Liberatori,Antonio Amoroso,Filippo Rossi Fanelli. (2015-02-28) The involvement of T regulatory lymphocytes in a cohort of lupus nephritis patients: a pilot study.. Internal and emergency medicine, 10 ((6)): (677-683). [PMID:25720575]
21. Gyan S Sahukhal,Justin L Batte,Mohamed O Elasri. (2015-03-01) msaABCR operon positively regulates biofilm development by repressing proteases and autolysis in Staphylococcus aureus.. FEMS microbiology letters, 362 ((4)): [PMID:25724778]
22. Moritz Jesinghaus,Thomas Wolf,Nicole Pfarr,Alexander Muckenhuber,Aysel Ahadova,Arne Warth,Benjamin Goeppert,Christine Sers,Matthias Kloor,Volker Endris,Albrecht Stenzinger,Wilko Weichert. (2015-03-19) Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer.. The American journal of surgical pathology, 39 ((8)): (1140-1147). [PMID:25786087]
23. Heyam Mohamed Ali Sidahmed,Najihah Mohd Hashim,Mahmood Ameen Abdulla,Hapipah Mohd Ali,Syam Mohan,Siddig Ibrahim Abdelwahab,Manal Mohamed Elhassan Taha,Loke Mun Fai,Jamuna Vadivelu. (2015-03-24) Antisecretory, gastroprotective, antioxidant and anti-Helicobcter pylori activity of zerumbone from Zingiber zerumbet (L.) Smith.. PloS one, 10 ((3)): (e0121060-e0121060). [PMID:25798602]
24. Yan Li,Wei Wang,Ping Huang,Qian Zhang,Xiujuan Yao,Jingjing Wang,Zhe Lv,Yunqing An,Chris J Corrigan,Kewu Huang,Sun Ying. (2015-03-27) Distinct sustained structural and functional effects of interleukin-33 and interleukin-25 on the airways in a murine asthma surrogate.. Immunology, 145 ((4)): (508-518). [PMID:25807992]
25. Sei-Myoung Han,Ye-Rin Coh,Jin-Ok Ahn,Goo Jang,Soo Young Yum,Sung-Keun Kang,Hee-Woo Lee,Hwa-Young Youn. (2015-03-31) Enhanced hepatogenic transdifferentiation of human adipose tissue mesenchymal stem cells by gene engineering with Oct4 and Sox2.. PloS one, 10 ((3)): (e0108874-e0108874). [PMID:25815812]
26. Ina Maria Kacsó,Gabriel Mircea Borza,Cătălin C Ciuce,Andrei Bîrsan,Raluca Cristina Apostu,George Călin Dindelegan,Cosmina Ioana Bondor,Alina Ramona Potra,Mihai G Netea,Cornel Cătoi. (2015-04-01) Expression of TLR4 protein is reduced in chronic renal failure: evidence from an experimental model of nephron reduction.. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 56 ((1)): (93-99). [PMID:25826492]
27. Boglárka Erdélyi-Belle,György Török,Ágota Apáti,Balázs Sarkadi,Zsuzsa Schaff,András Kiss,László Homolya. (2015-04-08) Expression of Tight Junction Components in Hepatocyte-Like Cells Differentiated from Human Embryonic Stem Cells.. Pathology oncology research : POR, 21 ((4)): (1059-1070). [PMID:25845432]
28. Anthony Vocat,Ruben C Hartkoorn,Benoit Lechartier,Ming Zhang,Neeraj Dhar,Stewart T Cole,Claudia Sala. (2015-04-22) Bioluminescence for assessing drug potency against nonreplicating Mycobacterium tuberculosis.. Antimicrobial agents and chemotherapy, 59 ((7)): (4012-4019). [PMID:25896710]
29. Liliya M Yamaleyeva,Victor M Pulgar,Sarah H Lindsey,Larissa Yamane,Jasmina Varagic,Carolynne McGee,Mauro daSilva,Paula Lopes Bonfa,Susan B Gurley,K Bridget Brosnihan. (2015-05-15) Uterine artery dysfunction in pregnant ACE2 knockout mice is associated with placental hypoxia and reduced umbilical blood flow velocity.. American journal of physiology. Endocrinology and metabolism, 309 ((1)): (E84-E94). [PMID:25968580]
30. Loes E M Kistemaker,Pieter S Hiemstra,I Sophie T Bos,Susanne Bouwman,Maarten van den Berge,Machteld N Hylkema,Herman Meurs,Huib A M Kerstjens,Reinoud Gosens. (2015-05-23) Tiotropium attenuates IL-13-induced goblet cell metaplasia of human airway epithelial cells.. Thorax, 70 ((7)): (668-676). [PMID:25995156]
31. Sebastian S Roeder,Ania Stefanska,Diana G Eng,Natalya Kaverina,Maria W Sunseri,Bairbre A McNicholas,Peter Rabinovitch,Felix B Engel,Christoph Daniel,Kerstin Amann,Julia Lichtnekert,Jeffrey W Pippin,Stuart J Shankland. (2015-05-29) Changes in glomerular parietal epithelial cells in mouse kidneys with advanced age.. American journal of physiology. Renal physiology, 309 ((2)): (F164-F178). [PMID:26017974]
32. Kathy Saraiva-Pava,Nazanin Navabi,Emma C Skoog,Sara K Lindén,Mónica Oleastro,Mónica Roxo-Rosa. (2015-06-16) New NCI-N87-derived human gastric epithelial line after human telomerase catalytic subunit over-expression.. World journal of gastroenterology, 21 ((21)): (6526-6542). [PMID:26074691]
33. Ryan J Day,Maria J Mason,Chloe Thomas,Wayne W Poon,Troy T Rohn. (2015-07-15) Caspase-Cleaved Tau Co-Localizes with Early Tangle Markers in the Human Vascular Dementia Brain.. PloS one, 10 ((7)): (e0132637-e0132637). [PMID:26161867]
34. Yong Zhang,Hou-Qin Xiao,Yang Wang,Zhuo-Shun Yang,Long-Jun Dai,Yan-Cheng Xu. (2015-07-15) Differential expression and therapeutic efficacy of microRNA-346 in diabetic nephropathy mice.. Experimental and therapeutic medicine, 10 ((1)): (106-112). [PMID:26170919]
35. Han-Jin Park,Young-Jun Choi,Ji Woo Kim,Hang-Suk Chun,Ilkyun Im,Seokjoo Yoon,Yong-Mahn Han,Chang-Woo Song,Hyemin Kim. (2015-07-16) Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes.. PloS one, 10 ((7)): (e0132992-e0132992). [PMID:26177506]
36. Theo F J Kraus,Andrea Greiner,Martina Steinmaurer,Vanessa Dietinger,Virginie Guibourt,Hans A Kretzschmar. (2015-08-19) Genetic Characterization of Ten-Eleven-Translocation Methylcytosine Dioxygenase Alterations in Human Glioma.. Journal of Cancer, 6 ((9)): (832-842). [PMID:26284134]
37. Shuo-Chun Weng,Kuo-Hsiung Shu,Ming-Ju Wu,Mei-Chin Wen,Shie-Liang Hsieh,Nien-Jung C. (2015-09-04) Expression of decoy receptor 3 in kidneys is associated with allograft survival after kidney transplant rejection.. Scientific reports, 5 (12769-12769). [PMID:26335204]
38. L Alameda,C Ferrari,P S Baumann,M Gholam-Rezaee,K Q Do,P Conus. (2015-09-10) Childhood sexual and physical abuse: age at exposure modulates impact on functional outcome in early psychosis patients.. Psychological medicine, 45 ((13)): (2727-2736). [PMID:26350397]
39. Wenjie Tian,Hongen Lei,Ruili Guan,Yongde Xu,Huixi Li,Lin Wang,Bicheng Yang,Zhezhu Gao,Zhongcheng Xin. (2015-09-18) Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats.. Drug design, development and therapy, 9 (5147-5157). [PMID:26379427]
40. Aiping Wang,Jing Li,Yang Zhao,Malin E V Johansson,Hua Xu,Fayez K Ghishan. (2015-10-28) Loss of NHE8 expression impairs intestinal mucosal integrity.. American journal of physiology. Gastrointestinal and liver physiology, 309 ((11)): (G855-G864). [PMID:26505975]
41. Hong-Xing Cai,Zheng-Qiu Zhu,Xiao-Ming Sun,Zhou-Ru Li,Yan-Bo Chen,Guo-Kai Dong. (2015-11-10) Gene expression profile of human esophageal squamous carcinoma cell line TE-1.. International journal of clinical and experimental medicine, 8 ((8)): (14268-14276). [PMID:26550410]
42. Daniel Lafkas,Amy Shelton,Cecilia Chiu,Gladys de Leon Boenig,Yongmei Chen,Scott S Stawicki,Christian Siltanen,Mike Reichelt,Meijuan Zhou,Xiumin Wu,Jeffrey Eastham-Anderson,Heather Moore,Meron Roose-Girma,Yvonne Chinn,Julie Q Hang,Søren Warming,Jackson Egen,Wyne P Lee,Cary Austin,Yan Wu,Jian Payandeh,John B Lowe,Christian W Siebel. (2015-11-19) Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.. Nature, 528 ((7580)): (127-131). [PMID:26580007]
43. Bahaa Al-Trad,Ibraheem M Ashankyty,Mohd Alaraj. (2015-11-20) Progesterone ameliorates diabetic nephropathy in streptozotocin-induced diabetic Rats.. Diabetology & metabolic syndrome, 7 (97-97). [PMID:26583047]
44. Serena Guidotti,Manuela Minguzzi,Daniela Platano,Luca Cattini,Giovanni Trisolino,Erminia Mariani,Rosa Maria Borzì. (2015-12-01) Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients.. PloS one, 10 ((11)): (e0143865-e0143865). [PMID:26618897]
45. Ivan Fernandez-Bueno,Salvatore Di Lauro,Ivan Alvarez,Jose Carlos Lopez,Maria Teresa Garcia-Gutierrez,Itziar Fernandez,Eva Larra,Jose Carlos Pastor. (2015-12-23) Safety and Biocompatibility of a New High-Density Polyethylene-Based Spherical Integrated Porous Orbital Implant: An Experimental Study in Rabbits.. Journal of ophthalmology, 2015 (904096-904096). [PMID:26689343]
46. Ahmet Nacar,Ihsan Karaboğa,Hamza Malik Okuyan,Nebihat Kaplan Sefil,Emel Nacar,Sedat Motor,Seçkin Akküçük,Orhan Veli Ozkan. (2016-01-19) Investigation of the protective effect of erdosteine against cyclosporine-induced injury in rat liver with histological and biochemical methods.. Turkish journal of medical sciences, 45 ((6)): (1390-1395). [PMID:26775399]
47. Diana Couto,Daniela Ribeiro,Marisa Freitas,Ana Gomes,José L F C Lima,Eduarda Fernandes. (2011-01-07) Scavenging of reactive oxygen and nitrogen species by the prodrug sulfasalazine and its metabolites 5-aminosalicylic acid and sulfapyridine.. Redox report : communications in free radical research, 15 ((6)): (259-267). [PMID:21208525]
48. . (2012-03-01) Drugs for inflammatory bowel disease.. Treatment guidelines from the Medical Letter, 10 ((115)): (19-28). [PMID:22361569]
49. Shuichi Yano,Kanako Kobayashi,Toshikazu Ikeda. (2012-05-19) Multidrug-resistant tuberculosis that required 2 years for diagnosis.. BMJ case reports, 2012 (doi:10-doi:10). [PMID:22605803]
50. Joo-Hee Kim,Seung Hun Jang,Dong Hoon Kim,Sunghoon Park,Dong-Gyu Kim,Ki-Suck Jung. (2013-01-29) A case of DRESS syndrome induced by the antituberculosis drugs, prothionamide, and para-aminosalycilic acid.. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 110 ((2)): (118-119). [PMID:23352532]
51. Judy Y Ku,Monisha E Nongpiur,Judy Park,Arun K Narayanaswamy,Shamira A Perera,Tin A Tun,Rajesh S Kumar,Mani Baskaran,Tin Aung. (2013-02-23) Qualitative evaluation of the iris and ciliary body by ultrasound biomicroscopy in subjects with angle closure.. Journal of glaucoma, 23 ((9)): (583-588). [PMID:23429617]
52. J Furin,G Brigden,E Lessem,M C Becerra. (2013-07-06) Novel pediatric delivery systems for second-line anti-tuberculosis medications: a case study.. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 17 ((9)): (1239-1241). [PMID:23827936]
53. Joan Cid,Laura Magnano,Maria Acosta,Cristina Alba,Jordi Esteve,Miguel Lozano. (2014-05-29) Rituximab, plasma exchange and intravenous immunoglobulins as a new treatment strategy for severe HLA alloimmune platelet refractoriness.. Platelets, 26 ((2)): (190-194). [PMID:24867634]
54. Asako Kaneoka,Gintas P Krisciunas,Kayo Walsh,Adele S Raade,Susan E Langmore. (2014-09-17) A comparison of 2 methods of endoscopic laryngeal sensory testing: a preliminary study.. The Annals of otology, rhinology, and laryngology, 124 ((3)): (187-193). [PMID:25225213]
55. Jitka Stancikova,Michaela Krausova,Michal Kolar,Bohumil Fafilek,Jiri Svec,Radislav Sedlacek,Magdalena Neroldova,Jan Dobes,Monika Horazna,Lucie Janeckova,Martina Vojtechova,Martin Oliverius,Milan Jirsa,Vladimir Korinek. (2014-12-03) NKD1 marks intestinal and liver tumors linked to aberrant Wnt signaling.. Cellular signalling, 27 ((2)): (245-256). [PMID:25446263]
56. Konrad Kowalski,Tomasz Goszczyński,Zbigniew J Leśnikowski,Janusz Boratyński. (2015-01-16) Synthesis of lysozyme-metallacarborane conjugates and the effect of boron cluster modification on protein structure and function.. Chembiochem : a European journal of chemical biology, 16 ((3)): (424-431). [PMID:25589498]
57. Jingxin Zhou,Wen Sun,Hisae Yoshitomi,Linyi Li,Lingling Qin,Xiangyu Guo,Lili Wu,Yan Zhang,Xinli Wu,Tunhai Xu,Ming Gao,Tonghua Liu. (2015-04-19) Qiwei granules alleviates podocyte lesion in kidney of diabetic KK-Ay mice.. BMC complementary and alternative medicine, 15 (97-97). [PMID:25887645]
58. Shaiban Jubair,Jianping Li,Heather M Dehlin,Edward J Manteufel,Paul H Goldspink,Scott P Levick,Joseph S Janicki. (2015-06-14) Substance P induces cardioprotection in ischemia-reperfusion via activation of AKT.. American journal of physiology. Heart and circulatory physiology, 309 ((4)): (H676-H684). [PMID:26071541]
59. Alex N Manin,Alexander P Voronin,Anastasia V Shishkina,Mikhail V Vener,Andrei V Churakov,German L Perlovich. (2015-08-11) Influence of Secondary Interactions on the Structure, Sublimation Thermodynamics, and Solubility of Salicylate:4-Hydroxybenzamide Cocrystals. Combined Experimental and Theoretical Study.. The journal of physical chemistry. B, 119 ((33)): (10466-10477). [PMID:26258951]
60. Tyler D Scherr,Mark L Hanke,Ouwen Huang,David B A James,Alexander R Horswill,Kenneth W Bayles,Paul D Fey,Victor J Torres,Tammy Kielian. (2015-08-27) Staphylococcus aureus Biofilms Induce Macrophage Dysfunction Through Leukocidin AB and Alpha-Toxin.. mBio, 6 ((4)): [PMID:26307164]
61. Yuan Gao, Yun Luo, Zhao Pan, Zhu Zeng, Wenxia Fan, Jingyu Hu, Zhong Zhang, Jinxing Ma, Yang Zhou, Jun Ma. (2024) Comparative study of Fe(II)/sulfite, Fe(II)/PDS and Fe(II)/PMS for p-arsanilic acid treatment: Efficient organic arsenic degradation and contrasting total arsenic removal. WATER RESEARCH, 249 (18): (120967). [PMID:38070343]
62. Qingxin Yang, Ying Liu, Fengniu Lu, Junqi Cheng, Siyuan Sun, Zhiqin Yuan, Chao Lu. (2024) Dopamine-based selective spectrophotometry p-aminosalicylic acid assay by hydrolyzate-triggered formation of azamonardine-like products. ANALYTICA CHIMICA ACTA, 1287 (17): (342059). [PMID:38182367]
63. Qiuyan Zhao, Mingyue Ding, Dangshuai Pei, Xiuhua Qi, Yexuan Mao, Xianqing Huang, Lianjun Song, Jingnan Zuo, Huijuan Yang, Xiya Zhang. (2023) Development of a monoclonal antibody-based lateral flow immunoassay for the detection of benzoic acid in liquid food. Analytical Methods, 15 (45): (6229-6238). [PMID:37943077]
64. Zhiyong Zheng, Yuehua Deng, Weining Xie, Sirui Chen, Xiaoxiao Liang, Shiyuan Liu, Yanbin Jiang, Huaiyu Yang. (2023) Co-Former Screening Method for Multicomponent Crystals Based on Partial Least Squares Regression: A Case Study of Ciprofloxacin. CRYSTAL GROWTH & DESIGN, 23 (5): (3244–3257). [PMID:]
65. Yanghe Liu, Quan Li, Shenghuan Wang, Mengzhu Liang, Yanhong Ji, Zhenyu Cui, Mohammad Younas, Jianxin Li, Benqiao He. (2023) A nanofiltration membrane with positively and negatively charged groups by grafted p-aminosalicylic acid-Fe(III) chelation for Li+/Mg2+ efficient separation. SEPARATION AND PURIFICATION TECHNOLOGY, 308 (122968). [PMID:]
66. Wen Liu, Jinyao Li, Zicheng Wang, Yafei Tian, Guodong Ren, Xiaoyu Hou, Lixia Guo, Lihong Li, Chengwu Zhang, Zhifang Wu, Lili Yan, Sijin Li, Haipeng Diao. (2022) Construction of mitochondria targeted and FRET based ratiometric sensing nanoplatform for sulfur dioxide accurate detection in vitro and in vivo. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 283 (121731). [PMID:36007349]
67. Guodong Ren, ZiCheng Wang, Yafei Tian, Jinyao Li, Yingyu Ma, Liang Zhou, Chengwu Zhang, Lixia Guo, Haipeng Diao, Lihong Li, Li Lu, Sufang Ma, Zhifang Wu, Lili Yan, Wen Liu. (2022) Targeted chemo-photodynamic therapy toward esophageal cancer by GSH-sensitive theranostic nanoplatform. BIOMEDICINE & PHARMACOTHERAPY, 153 (113506). [PMID:36076595]
68. Yuehua Deng, Yuchen Chen, Fang Xie, Jingwen Tang, Rui Zhang, Huaiyu Yang, Yanbin Jiang, Shiyuan Liu. (2022) Minoxidil Multi-Component Crystals with Aromatic Carboxylic Acids: Theoretical Calculation and Structural Analysis. CRYSTAL GROWTH & DESIGN, 22 (6): (3941–3953). [PMID:]
69. Evgeniya V Polyakova,Olga V Shuvaeva,Olga S Koshcheeva,Yuliya E Tyutereva,Ivan P Pozdnyakov. (2020-11-14) Capillary zone electrophoresis as a simple approach for the study of p-arsanilic acid transformation in the process of photolytic degradation.. Electrophoresis, 42 ((6)): (719-724). [PMID:33185273]

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4-Aminosalicylic acid - 98%, high purity , Dihydrofolate reductase inhibitor, CAS No.65-49-6, Dihydrofolate reductase inhibitor

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