Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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B100826-5g | 5g | In stock | $11.90 | |
B100826-10g | 10g | In stock | $18.90 | |
B100826-25g | 25g | In stock | $35.90 | |
B100826-100g | 100g | In stock | $95.90 | |
B100826-500g | 500g | In stock | $333.90 |
Induces loss of epidermal melanocytes in vivo
Synonyms | Monobenzone | 4-Benzyloxyphenol | 103-16-2 | 4-(Benzyloxy)phenol | Hydroquinone monobenzyl ether | Benoquin | P-(BENZYLOXY)PHENOL | Benzoquin | Monobenzyl hydroquinone | Hydroquinone benzyl ether | Leucodinine | Monobenzon | Superlite | Agerite alba | 4-(Phenylmethoxy)phenol | p-Hydro |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Induces loss of epidermal melanocytes in vivo . Induces T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy. Skin depigmentation and immunotherapy agent. Active in vivo. |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Tyrosinase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 3.4 |
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Pubchem Sid | 488180509 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488180509 |
IUPAC Name | 4-phenylmethoxyphenol |
INCHI | InChI=1S/C13H12O2/c14-12-6-8-13(9-7-12)15-10-11-4-2-1-3-5-11/h1-9,14H,10H2 |
InChi Key | VYQNWZOUAUKGHI-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)COC2=CC=C(C=C2)O |
Isomeric SMILES | C1=CC=C(C=C1)COC2=CC=C(C=C2)O |
WGK Germany | 2 |
RTECS | SJ7700000 |
PubChem CID | 7638 |
UN Number | 2430 |
Molecular Weight | 200.23 |
Beilstein | 1958305 |
Reaxy-Rn | 1958305 |
DrugBank Ligand | DB00600 |
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PubChem CID | 7638 |
CAS Registry No. | 103-16-2 |
ChEMBL Ligand | CHEMBL1388 |
Wikipedia | Monobenzone |
DrugCentral Ligand | 1834 |
PubChem SID | 488180509 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2403144 | Certificate of Analysis | Apr 23, 2024 | B100826 |
A2206918 | Certificate of Analysis | Oct 12, 2023 | B100826 |
A2206920 | Certificate of Analysis | Oct 12, 2023 | B100826 |
A2206916 | Certificate of Analysis | Oct 12, 2023 | B100826 |
I2103040 | Certificate of Analysis | Jun 07, 2023 | B100826 |
I2103039 | Certificate of Analysis | Jun 07, 2023 | B100826 |
I2103038 | Certificate of Analysis | Jun 07, 2023 | B100826 |
F23301066 | Certificate of Analysis | Jun 02, 2023 | B100826 |
F23301067 | Certificate of Analysis | Jun 02, 2023 | B100826 |
F2330427 | Certificate of Analysis | Jun 02, 2023 | B100826 |
F2330433 | Certificate of Analysis | Jun 02, 2023 | B100826 |
F2330443 | Certificate of Analysis | Jun 02, 2023 | B100826 |
F2330444 | Certificate of Analysis | Jun 02, 2023 | B100826 |
H2026047 | Certificate of Analysis | Jun 17, 2022 | B100826 |
H2026046 | Certificate of Analysis | Jun 17, 2022 | B100826 |
E2324091 | Certificate of Analysis | Dec 17, 2021 | B100826 |
C2308350 | Certificate of Analysis | Dec 17, 2021 | B100826 |
B2315202 | Certificate of Analysis | Dec 17, 2021 | B100826 |
B2306869 | Certificate of Analysis | Dec 17, 2021 | B100826 |
Solubility | Slightly soluble in water. Soluble in alcohol, acetone, benzene, and diethyl ether. |
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Sensitivity | light sensitive |
Melt Point(°C) | 117-122°C |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H317:May cause an allergic skin reaction |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. |
WGK Germany | 2 |
RTECS | SJ7700000 |
Reaxy-Rn | 1958305 |
Merck Index | 6248 |
Starting at $191.90
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2. A B Lerner. (1992-01-01) The Seiji memorial lecture. Pigment stories: from vitiligo to melanomas and points in between.. Pigment cell research, (19-21). [PMID:1409420] |
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5. N Haas. (1988-05-13) [Confetti-like dyschromia caused by a bleaching cream containing hydroquinone in racially pigmented patients].. Medizinische Klinik (Munich, Germany : 1983), 83 ((11)): (385-386). [PMID:3405155] |
6. E Frenk. (1986-01-01) [Treatment of vitiligo].. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 37 ((1)): (1-5). [PMID:3949507] |
7. T Tezuka,M Saheki,S Kusuda,K Umemoto. (1993-05-01) Treatment of nonhairy melanocytic macules by dermabrasion and topical application of 5% hydroquinone monobenzyl ether cream.. Journal of the American Academy of Dermatology, 28 ((5 Pt 1)): (771-772). [PMID:8496423] |
8. A K Bajaj,S C Gupta,A K Chatterjee. (1996-08-01) Footwear depigmentation.. Contact dermatitis, 35 ((2)): (117-118). [PMID:8917842] |
9. C C Lyon,M H Beck. (1998-10-15) Contact hypersensitivity to monobenzyl ether of hydroquinone used to treat vitiligo.. Contact dermatitis, 39 ((3)): (132-133). [PMID:9771988] |
10. Markus A Lill,Fabienne Winiger,Angelo Vedani,Beat Ernst. (2005-09-02) Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.. Journal of medicinal chemistry, 48 ((18)): (5666-5674). [PMID:16134935] |
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13. Vidhya Hariharan,Jared Klarquist,Mary J Reust,Amy Koshoffer,Mark D McKee,Raymond E Boissy,I Caroline Le Poole. (2009-08-07) Monobenzyl ether of hydroquinone and 4-tertiary butyl phenol activate markedly different physiological responses in melanocytes: relevance to skin depigmentation.. The Journal of investigative dermatology, 130 ((1)): (211-220). [PMID:19657355] |
14. Jasper G van den Boorn,Debby Konijnenberg,Esther P M Tjin,Daisy I Picavet,Nico J Meeuwenoord,Dmitri V Filippov,J P Wietze van der Veen,Jan D Bos,Cornelis J M Melief,Rosalie M Luiten. (2010-05-26) Effective melanoma immunotherapy in mice by the skin-depigmenting agent monobenzone and the adjuvants imiquimod and CpG.. PloS one, 5 ((5)): (e10626-e10626). [PMID:20498710] |
15. Jasper G van den Boorn,Daisy I Picavet,Paul F van Swieten,Henk A van Veen,Debby Konijnenberg,Peter A van Veelen,Toni van Capel,Esther C de Jong,Eric A Reits,Jan W Drijfhout,Jan D Bos,Cornelis J M Melief,Rosalie M Luiten. (2011-02-18) Skin-depigmenting agent monobenzone induces potent T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy.. The Journal of investigative dermatology, 131 ((6)): (1240-1251). [PMID:21326294] |
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19. Jonathan G Bonchak,Jonathan M Eby,Kristin A Willenborg,David Chrobak,Steven W Henning,Anna Krzywiec,Steven L Johnson,I Caroline Le Poole. (2014-08-19) Targeting melanocyte and melanoma stem cells by 8-hydroxy-2-dipropylaminotetralin.. Archives of biochemistry and biophysics, 563 (71-78). [PMID:25132642] |
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22. C Sanz de Galdeano,A Aguirre,R Zabala,J A Ratón,J L Díaz-Pérez. (1993-07-01) Achromic patch test from hydroquinone monobenzyl ether.. Contact dermatitis, 29 ((1)): (43-44). [PMID:8365157] |
23. A M Oakley. (1996-05-01) Rapid repigmentation after depigmentation therapy: vitiligo treated with monobenzyl ether of hydroquinone.. The Australasian journal of dermatology, 37 ((2)): (96-98). [PMID:8687336] |
24. T A Wee. (1997-02-01) A case report of extensive vitiligo.. Hawaii medical journal, 56 ((2)): (37-40). [PMID:9063009] |
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26. K M AlGhamdi,A Kumar. (2010-11-09) Depigmentation therapies for normal skin in vitiligo universalis.. Journal of the European Academy of Dermatology and Venereology : JEADV, 25 ((7)): (749-757). [PMID:21054565] |
27. Jasper G van den Boorn,Cornelis J Melief,Rosalie M Luiten. (2011-06-22) Monobenzone-induced depigmentation: from enzymatic blockade to autoimmunity.. Pigment cell & melanoma research, 24 ((4)): (673-679). [PMID:21689385] |
28. Jia-Pei Guo, Fang-Jing Liu, Lei-Lei Bie, Xing-Gang Si, Yan-Hong Li, Ping Song, Nian Liu, Yun-Peng Zhao, Zai-Xing Huang, Jing-Pei Cao, Xian-Yong Wei. (2022) Selective cleavage of C–O bond in lignin and lignin model compounds over iron/nitrogen co-doped carbon supported Ni catalyst. FUEL, 316 (123338). [PMID:] |