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Transmembrane Transporters
Voltage-gated ion channels
Transient Receptor Potential channels (TRP)
4-chloro-2-[(2-naphthalen-1-yloxyacetyl)amino]benzoic acid , CAS No.C609390, Channel blocker of TRPM4;Gating inhibitor of TRPM4

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4-chloro-2-[(2-naphthalen-1-yloxyacetyl)amino]benzoic acid , CAS No.C609390, Channel blocker of TRPM4;Gating inhibitor of TRPM4

Moligand™

PubChem CID: 1295523

Item Number

C609390

Grouped product items
SKU	Size	Availability	Price	Qty
C609390-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C609390-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,001.90

View related series

TRPM4 Channel blocker TRPM4 Gating inhibitor

Basic Description

Synonyms	NBA;compound 6
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	CHANNEL BLOCKER, GATING INHIBITOR
Mechanism of action	Channel blocker of TRPM4;Gating inhibitor of TRPM4

Associated Targets

GMNN Tbio Geminin 0 Activities

Discover Target: GMNN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RORC Tchem Nuclear receptor ROR-gamma 0 Activities

Discover Target: RORC

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPM4 Tchem Transient receptor potential cation channel subfamily M member 4 2 Activities

Discover Target: TRPM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

WRN Tbio Werner syndrome ATP-dependent helicase 0 Activities

Discover Target: WRN

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

POLI Tchem DNA polymerase iota 0 Activities

Discover Target: POLI

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLK1 Tchem Serine/threonine-protein kinase PLK1 0 Activities

Discover Target: PLK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GNAS Tbio Protein ALEX 0 Activities

Discover Target: GNAS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

Discover Target: GLP1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-chloro-2-[(2-naphthalen-1-yloxyacetyl)amino]benzoic acid
INCHI	InChI=1S/C19H14ClNO4/c20-13-8-9-15(19(23)24)16(10-13)21-18(22)11-25-17-7-3-5-12-4-1-2-6-14(12)17/h1-10H,11H2,(H,21,22)(H,23,24)
InChi Key	OKFVCWAYHJMQFA-UHFFFAOYSA-N
Canonical SMILES	O=C(Nc1cc(Cl)ccc1C(=O)O)COc1cccc2c1cccc2
Isomeric SMILES	C1=CC=C2C(=C1)C=CC=C2OCC(=O)NC3=C(C=CC(=C3)Cl)C(=O)O
PubChem CID	1295523

Database links

PubChem CID	1295523
ChEMBL Ligand	CHEMBL1408302
BindingDB Ligand	96504

Certificates

Certificate of Analysis(COA)

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References

1. Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, Ross-Kaschitza D, Simonin C, Rubin M, Gertsch J et al.. (2018) Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.. Br J Pharmacol, 175 (12): (2504-2519). [PMID:29579323]

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