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4-chloro-2-[(2-naphthalen-1-yloxyacetyl)amino]benzoic acid , CAS No.C609390, Channel blocker of TRPM4;Gating inhibitor of TRPM4
Basic Description
| Specifications & Purity | Moligand™ |
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| Grade | Moligand™ |
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| Action Type | CHANNEL BLOCKER, GATING INHIBITOR |
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| Mechanism of action | Channel blocker of TRPM4;Gating inhibitor of TRPM4 |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 4-chloro-2-[(2-naphthalen-1-yloxyacetyl)amino]benzoic acid |
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| INCHI | InChI=1S/C19H14ClNO4/c20-13-8-9-15(19(23)24)16(10-13)21-18(22)11-25-17-7-3-5-12-4-1-2-6-14(12)17/h1-10H,11H2,(H,21,22)(H,23,24) |
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| InChi Key | OKFVCWAYHJMQFA-UHFFFAOYSA-N |
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| Canonical SMILES | O=C(Nc1cc(Cl)ccc1C(=O)O)COc1cccc2c1cccc2 |
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| Isomeric SMILES | C1=CC=C2C(=C1)C=CC=C2OCC(=O)NC3=C(C=CC(=C3)Cl)C(=O)O |
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| PubChem CID | 1295523 |
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References
| 1. Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, Ross-Kaschitza D, Simonin C, Rubin M, Gertsch J et al.. (2018) Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.. Br J Pharmacol, 175 (12): (2504-2519). [PMID:29579323] [10.1021/op500134e] |
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