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4-Chloro-L-phenylalanine - 98%, high purity , CAS No.14173-39-8 1 Citations
Basic Description Synonyms 14173-39-8 | 4-CHLORO-L-PHENYLALANINE | L-4-Chlorophenylalanine | H-Phe(4-Cl)-OH | (S)-2-amino-3-(4-chlorophenyl)propanoic acid | (2S)-2-amino-3-(4-chlorophenyl)propanoic acid | Fenclonine, (S)- | L-p-Chlorophenylalanine | L-Phenylalanine, 4-chloro- | L-PHE(4-CL)-OH | 4-Chlo Specifications & Purity ≥98% Biochemical and Physiological Mechanisms 4-Chloro-L-phenylalanine (L-PCPA) inhibits the synthesis of 5-hydroxytryptamine (5-HT). 4-Chloro-DL-phenylalanine (PCPA) depletes the serotonin levels in the brain by its inhibitory effect on tryptophan hydroxylase (Tph). Studies support the protective ef Storage Temp Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Product Description Application
4-Chloro-L-phenylalanine (L-PCPA) has been used:
to block serotonin synthesis by inhibiting tryptophan hydroxylase (TPH)
to study its behavioral and electrographic effects on epileptic senegalese baboon (Papiopapio)
as a substrate for Chromobacteriumviolaceum phenylalanine hydroxylase
to incubate sea urchin embryos for immunohistochemistry
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name (2S)-2-amino-3-(4-chlorophenyl)propanoic acid INCHI InChI=1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1 InChi Key NIGWMJHCCYYCSF-QMMMGPOBSA-N Canonical SMILES C1=CC(=CC=C1CC(C(=O)O)N)Cl Isomeric SMILES C1=CC(=CC=C1C[C@@H](C(=O)O)N)Cl WGK Germany 3 PubChem CID 736190 UN Number 2811 Molecular Weight 199.63 Beilstein 2416150
Chemical and Physical Properties Solubility Soluble in acetic acid. Slightly soluble in water. Sensitivity Air sensitive Melt Point(°C) 235-238°C
Safety and Hazards(GHS) Pictogram(s) GHS06 , GHS07 Signal Danger Hazard Statements H301: Toxic if swallowed
H317: May cause an allergic skin reaction
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P272: Contaminated work clothing should not be allowed out of the workplace.
P333+P313: IF SKIN irritation or rash occurs: Get medical advice/attention.
P362+P364: Take off contaminated clothing and wash it before reuse.
P330: Rinse mouth.
P301+P316: IF SWALLOWED: Get emergency medical help immediately.
WGK Germany 3
Citations of This Product 1. Kunya Cheng, Binchen Wang, Lin Xiao, Yuxiang Bao, Xianbing Xu, Sufang Zhang, Zhaofang Liu, Liang Dong. (2022) Comprehensive metabolite analysis of wheat dough in a continuous heating process. FOOD RESEARCH INTERNATIONAL, 153 (110972). [PMID:35227483 ]
References 1. Kunya Cheng, Binchen Wang, Lin Xiao, Yuxiang Bao, Xianbing Xu, Sufang Zhang, Zhaofang Liu, Liang Dong. (2022) Comprehensive metabolite analysis of wheat dough in a continuous heating process. FOOD RESEARCH INTERNATIONAL, 153 (110972). [PMID:35227483 ]
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