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4-Ethoxyaniline - 98%, high purity , CAS No.156-43-4

2 Citations

≥98%

CAS#: 156-43-4
Formula: C₈H₁₁NO
Molecular Weight: 137.18
Beilstein Registry Number: 606666
EC Number: 205-855-5
MDL number: MFCD00007865
PubChem CID: 9076

Item Number

E108459

Grouped product items
SKU	Size	Availability	Price
E108459-25g	25g	In stock	$30.90
E108459-100g	100g	In stock	$109.90
E108459-500g	500g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$492.90

View related series

Nitrogenous compounds Non heterocyclic block

Basic Description

Synonyms	4-Ethoxybenzenamine \| Ethyl p-aminophenol \| AMY38132 \| E78819 \| BRN 0606666 \| NCGC00091785-01 \| p-aminophenyl ethyl ether \| STR01492 \| CAS-156-43-4 \| EINECS 205-855-5 \| CP 5685 \| STK397546 \| NSC 3116 \| Z57127438 \| AKOS000100572 \| Aniline, p-ethoxy- \| BIDD
Specifications & Purity	≥98%
Storage Temp	Store at 2-8°C,Argon charged
Shipped In	Wet ice

Associated Targets(Human)

CYP46A1 Tchem Cholesterol 24-hydroxylase (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

UGT1A4 Tbio UDP-glucuronosyltransferase 1-4 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TSHR Tclin Thyrotropin receptor (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GNAS Tbio Protein ALEX (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAOA Tclin Amine oxidase [flavin-containing] A (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KPNB1 Tbio Importin subunit beta-1 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PPARD Tchem Peroxisome proliferator-activated receptor delta (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NFE2L2 Tchem Nuclear factor erythroid 2-related factor 2 (0 Activities)

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MAOA Tclin Monoamine oxidase A (11911 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

UGT1A4 Tbio UDP-glucuronosyltransferase 1A4 (288 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Lymphoblastoid cell (5959 Activities)

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GNAS Tbio Guanine nucleotide-binding protein G(s), subunit alpha (103405 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAN Tchem GTP-binding nuclear protein Ran/Importin subunit beta-1/Snurportin-1 (21853 Activities)

Discover Target: RAN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Ppard Peroxisome proliferator-activated receptor delta (358 Activities)

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Mycobacterium tuberculosis (203094 Activities)

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Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)

Discover Target: Nfe2l2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

vpr Aberrant vpr protein (14595 Activities)

Discover Target: vpr

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	4-ethoxyaniline
INCHI	InChI=1S/C8H11NO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2,9H2,1H3
InChi Key	IMPPGHMHELILKG-UHFFFAOYSA-N
Canonical SMILES	CCOC1=CC=C(C=C1)N
Isomeric SMILES	CCOC1=CC=C(C=C1)N
WGK Germany	1
RTECS	SI6465500
PubChem CID	9076
UN Number	2311
Packing Group	III
Molecular Weight	137.18
Beilstein	606666
Reaxy-Rn	606666

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot Number	Certificate Type	Date	Item
C2414526	Certificate of Analysis	Mar 01, 2024	E108459
C2020134	Certificate of Analysis	Jan 11, 2024	E108459
C2307094	Certificate of Analysis	Oct 19, 2021	E108459
F2405103	Certificate of Analysis	Oct 19, 2021	E108459
L2418114	Certificate of Analysis	Oct 19, 2021	E108459

Chemical and Physical Properties

Solubility	Not miscible or difficult to mix in water.
Sensitivity	Heat & Light & Air sensitive
Refractive Index	1.559
Flash Point(°F)	284 °F
Flash Point(°C)	116 °C
Boil Point(°C)	250°C
Melt Point(°C)	2-5°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H319:Causes serious eye irritation H341:Suspected of causing genetic defects H302:Harmful if swallowed H317:May cause an allergic skin reaction H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P272:Contaminated work clothing should not be allowed out of the workplace. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help.
WGK Germany	1
RTECS	SI6465500
Reaxy-Rn	606666
Class	6.1
Merck Index	7228

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Hai-Xia Yu, Xinxin Yu, Siwei Chen, Jingcheng Hao, Lu Xu. (2023) A monosurfactant-stabilized dual-responsive and versatile emulsion lubricant. Journal of Cleaner Production, 406 (137089). [PMID:] [10.1016/j.jclepro.2023.137089]
2. Chi Chen, Yangyuanchen Liu, Ximin He, Hua Li, Yujie Chen, Ying Wei, Yusen Zhao, Yanfei Ma, Zhen Chen, Xu Zheng, Hezhou Liu. (2021) Multiresponse Shape-Memory Nanocomposite with a Reversible Cycle for Powerful Artificial Muscles. CHEMISTRY OF MATERIALS, 33 (3): (987–997). [PMID:] [10.1021/acs.chemmater.0c04170]

References

1. M Sato,F Furukawa,T Kawanishi,K Toyoda,T Imazawa,J Suzuki,M Takahashi. (1991-01-01) [Twenty-eight-day repeated dose toxicity test of p-phenetidine in F344 rats].. Eisei Shikenjo hokoku. Bulletin of National Institute of Hygienic Sciences, ((109)(109)): (42-48). [PMID:1364403]
2. C B Jensen,D J Jollow. (1991-10-01) The role of N-hydroxyphenetidine in phenacetin-induced hemolytic anemia.. Toxicology and applied pharmacology, 111 ((1)): (1-12). [PMID:1949026]
3. V Fischer,L S Harman,P R West,R P Mason. (1986-11-01) Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.. Chemico-biological interactions, 60 ((2)): (115-127). [PMID:3024853]
4. D Ross,K Norbeck,P Moldéus. (1985-12-05) The generation and subsequent fate of glutathionyl radicals in biological systems.. The Journal of biological chemistry, 260 ((28)): (15028-15032). [PMID:2999101]
5. T Nohmi,K Mizokami,S Kawano,M Fukuhara,M Ishidate. (1987-02-01) Metabolic activation of phenacetin and phenetidine by several forms of cytochrome P-450 purified from liver microsomes of rats and hamsters.. Japanese journal of cancer research : Gann, 78 ((2)): (153-161). [PMID:3104258]
6. K Togei,N Sano,T Maeda,M Shibata,H Otsuka. (1987-11-01) Carcinogenicity of bucetin in (C57BL/6 X C3H)F1 mice.. Journal of the National Cancer Institute, 79 ((5)): (1151-1158). [PMID:3479641]
7. E C McCoy,H S Rosenkranz,H Bartsch. (1986-04-01) Mutagenicity of the phenacetin metabolites: N-hydroxy-p-phenetidine and nitrosophenetol in S. typhimurium TA100 and derivatives deficient in nitroreductase or O-acetylase: probes for testing intrabacterial metabolic activation.. Mutation research, 173 ((4)): (245-250). [PMID:3513003]
8. J D Baty,R M Lindsay,S Sharp. (1986-02-26) Use of high-performance liquid chromatography in the measurement of in vitro acetylation in man.. Journal of chromatography, 353 (329-337). [PMID:3700517]
9. R Larsson,D Ross,T Berlin,L I Olsson,P Moldéus. (1985-11-01) Prostaglandin synthase catalyzed metabolic activation of p-phenetidine and acetaminophen by microsomes isolated from rabbit and human kidney.. The Journal of pharmacology and experimental therapeutics, 235 ((2)): (475-480). [PMID:3932643]
10. P Moldéus,D Ross,R Larsson. (1985-10-01) Co-oxidation of xenobiotics.. Biochemical Society transactions, 13 ((5)): (847-850). [PMID:3934012]
11. K Imai,T Fukushima,H Yokosu. (1994-05-01) A novel electrophilic reagent, 4-(N-chloroformylmethyl-N-methyl)amino- 7-N,N-dimethylaminosulphonyl-2,1,3-benzoxadiazole (DBD-COCl) for fluorometric detection of alcohols, phenols, amines and thiols.. Biomedical chromatography : BMC, 8 ((3)): (107-113). [PMID:8075519]
12. Esko Kankuri,Erkka Solatunturi,Heikki Vapaatalo. (2003-11-01) Effects of phenacetin and its metabolite p-phenetidine on COX-1 and COX-2 activities and expression in vitro.. Thrombosis research, 110 ((5-6)): (299-303). [PMID:14592552]
13. Annabel Kuek,Brian L Hazleman,Andrew J K Ostör. (2007-04-04) Immune-mediated inflammatory diseases (IMIDs) and biologic therapy: a medical revolution.. Postgraduate medical journal, 83 ((978)): (251-260). [PMID:17403952]
14. Yuki Kobayashi,Tatsuki Fukami,Ryota Higuchi,Miki Nakajima,Tsuyoshi Yokoi. (2012-09-04) Metabolic activation by human arylacetamide deacetylase, CYP2E1, and CYP1A2 causes phenacetin-induced methemoglobinemia.. Biochemical pharmacology, 84 ((9)): (1196-1206). [PMID:22940574]
15. Mai Shimizu,Tatsuki Fukami,Miki Nakajima,Tsuyoshi Yokoi. (2014-04-23) Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase.. Drug metabolism and disposition: the biological fate of chemicals, 42 ((7)): (1103-1109). [PMID:24751575]
16. Snežana D Marković,Nataša Z Dorđević,Milena G Curčić,Andraš S Stajn,Mihajlo B Spasić. (2014-08-26) Biotransformation and nitroglycerin-induced effects on antioxidative defense system in rat erythrocytes and reticulocytes.. General physiology and biophysics, 33 ((4)): (393-401). [PMID:25146184]
17. Caroline Bylda,Vanya Velichkova,Jens Bolle,Roland Thiele,Uwe Kobold,Dietrich A Volmer. (2014-09-19) Magnetic beads as an extraction medium for simultaneous quantification of acetaminophen and structurally related compounds in human serum.. Drug testing and analysis, 7 ((6)): (457-466). [PMID:25231125]
18. Rui Ren,Yongmei Ma,Wanshan Ma,Sumei Lu. (2016-02-18) The Assessment of Liver Reserve Function by Spectrophotometry based on Determination of Phenacetin and Paracetamol.. Clinical laboratory, 61 ((12)): (1927-1934). [PMID:26882817]
19. Tomohiro Yoshida,Tatsuki Fukami,Takaya Kurokawa,Saki Gotoh,Akifumi Oda,Miki Nakajima. (2017-10-03) Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 111 (167-176). [PMID:28966098]
20. A Zerrouki,M J Salar-García,V M Ortiz-Martínez,S Guendouz,H Ilikti,A P de Los Ríos,F J Hernández-Fernández,M Kameche. (2018-02-20) Synthesis of low cost organometallic-type catalysts for their application in microbial fuel cell technology.. Environmental technology, 40 ((18)): (2425-2435). [PMID:29455622]
21. T Lindqvist,P Moldéus,B Lindeke. (1991-08-01) Cellular effects of some metabolic oxidation products pertinent to 4-ethoxyaniline.. Pharmacology & toxicology, 69 ((2)): (117-121). [PMID:1775431]
22. T Lindqvist,L Kenne,B Lindeke. (1991-07-01) On the chemistry of the reaction between N-acetylcysteine and 4-[(4-ethoxyphenyl)imino]-2,5-cyclohexadien-1-one, a 4-ethoxyaniline metabolite formed during peroxidase reactions.. Chemical research in toxicology, 4 ((4)): (489-496). [PMID:1912338]
23. R Rachtan,A Starek. (1990-01-01) [Antipyretic action of aniline derivatives in rats during different parts of the day].. Folia medica Cracoviensia, 31 ((4)): (289-302). [PMID:2135897]
24. J A Hinson,J B Mays. (1986-07-01) Covalent binding of the phenacetin metabolite p-nitrosophenetole to protein.. The Journal of pharmacology and experimental therapeutics, 238 ((1)): (106-112). [PMID:3723393]
25. R Larsson,T Lindqvist,B Lindeke,P Moldéus. (1986-12-01) Cellular effects of N(4-ethoxyphenyl)p-benzoquinone imine, a p-phenetidine metabolite formed during peroxidase reactions.. Chemico-biological interactions, 60 ((3)): (317-330). [PMID:3791494]
26. J Pauluhn,U Mohr. (2001-11-07) Inhalation toxicity of 4-ethoxyaniline (p-phenetidine): critical analysis of results of subacute inhalation exposure studies in rats.. Inhalation toxicology, 13 ((11)): (993-1013). [PMID:11696870]
27. Anna Gulkowska,Martin Krauss,Daniel Rentsch,Juliane Hollender. (2012-01-21) Reactions of a sulfonamide antimicrobial with model humic constituents: assessing pathways and stability of covalent bonding.. Environmental science & technology, 46 ((4)): (2102-2111). [PMID:22260423]
28. Tamer Nasr,Samir Bondock,Mahmoud Youns,Walid Fayad,Wafaa Zaghary. (2017-11-07) Synthesis, antitumor evaluation and microarray study of some new pyrazolo[3,4-d][1,2,3]triazine derivatives.. European journal of medicinal chemistry, 141 (603-614). [PMID:29107422]
29. Andreas Kranawetvogl,Paul W Elsinghorst. (2019-05-17) Determination of the Synthetic Antioxidant Ethoxyquin and Its Metabolites in Fish and Fishery Products Using Liquid Chromatography-Fluorescence Detection and Stable-Isotope Dilution Analysis-Liquid Chromatography-Tandem Mass Spectrometry.. Journal of agricultural and food chemistry, 67 ((23)): (6650-6657). [PMID:31094514]
30. Morena Gabriele,Paola Puccini,Marco Lucchi,Vittorio Aprile,Pier Giovanni Gervasi,Vincenzo Longo. (2019-06-27) Arylacetamide Deacetylase Enzyme: Presence and Interindividual Variability in Human Lungs.. Drug metabolism and disposition: the biological fate of chemicals, 47 ((9)): (961-965). [PMID:31235486]
31. Fumiya Kisui,Tatsuki Fukami,Masataka Nakano,Miki Nakajima. (2019-11-15) Strain and sex differences in drug hydrolase activities in rodent livers.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 142 (105143-105143). [PMID:31726091]
32. Markus Stoeckelhuber,Max Scherer,Franz Bracher,Oliver Peschel,Edgar Leibold,Gerhard Scherer,Nikola Pluym. (2020-08-26) Development of a human biomonitoring method for assessing the exposure to ethoxyquin in the general population.. Archives of toxicology, 94 ((12)): (4209-4217). [PMID:32840639]
33. Hai-Xia Yu, Xinxin Yu, Siwei Chen, Jingcheng Hao, Lu Xu. (2023) A monosurfactant-stabilized dual-responsive and versatile emulsion lubricant. Journal of Cleaner Production, 406 (137089). [PMID:] [10.1016/j.jclepro.2023.137089]
34. Chi Chen, Yangyuanchen Liu, Ximin He, Hua Li, Yujie Chen, Ying Wei, Yusen Zhao, Yanfei Ma, Zhen Chen, Xu Zheng, Hezhou Liu. (2021) Multiresponse Shape-Memory Nanocomposite with a Reversible Cycle for Powerful Artificial Muscles. CHEMISTRY OF MATERIALS, 33 (3): (987–997). [PMID:] [10.1021/acs.chemmater.0c04170]

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