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F105088-25g

25g

In stock

$27.90

F105088-100g

100g

In stock

$71.90

F105088-250g

250g

Available within 4-8 weeks(?)

$160.90

F105088-500g

500g

Available within 4-8 weeks(?)

$302.90

Basic Description

Synonyms	SY001592 \| Q63390495 \| 4-flouro benzoic acid \| InChI=1/C7H5FO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10 \| 4-fluoro benzoic acid \| C02371 \| EN300-18213 \| Benzoic acid, 4-fluoro- \| D70922 \| UNII-V5ROO2HOU4 \| 4-Fluorobenzoicacid \| CS-W014393 \| F2191-0062 \| para
Specifications & Purity	≥98%
Shipped In	Normal

Associated Targets(Human)

CLPP Tchem ATP-dependent Clp protease proteolytic subunit, mitochondrial (0 Activities)

Discover Target: CLPP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Associated Targets(non-human)

Curvularia lunata (722 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

clpP ATP-dependent Clp protease proteolytic subunit (245 Activities)

Discover Target: clpP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Whole blood (71 Activities)

Discover Target:

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

Pubchem Sid	488181065
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488181065
IUPAC Name	4-fluorobenzoic acid
INCHI	InChI=1S/C7H5FO2/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H,9,10)
InChi Key	BBYDXOIZLAWGSL-UHFFFAOYSA-N
Canonical SMILES	C1=CC(=CC=C1C(=O)O)F
Isomeric SMILES	C1=CC(=CC=C1C(=O)O)F
WGK Germany	3
PubChem CID	9973
Molecular Weight	140.11
Beilstein	1906922
Reaxy-Rn	1906922

Certificates

Certificate of Analysis(COA)

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Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
I1805103	Certificate of Analysis	Jul 12, 2022	F105088
C2311721	Certificate of Analysis	Nov 24, 2021	F105088
D23111152	Certificate of Analysis	Nov 24, 2021	F105088
K2117941	Certificate of Analysis	Nov 24, 2021	F105088

Chemical and Physical Properties

Solubility	Solubility in water: Practically insoluble; Soluble in Ether,Alcohol
Sensitivity	Moisture sensitive.
Melt Point(°C)	183-185°C

Safety and Hazards(GHS)

Pictogram(s)	GHS05, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H318:Causes serious eye damage
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
Reaxy-Rn	1906922
Merck Index	4171

Citations of This Product

1. Siyuan Chang, Sen Zhang, Tianyi Chen, Lei Xu, Sumin Ge, Bingfeng Li, Chenke Yun, Guoxin Zhang, Xuejun He, Xin Pan. (2023) Efficient synthesis of 5-hydroxymethyl-2-furancarboxylic acid from bio-based high-concentration 5-hydroxymethylfurfural via highly tolerant aldehyde dehydrogenase. Molecular Catalysis, 538 (112966). [PMID:]

References

1. V Romanov,R P Hausinger. (1996-05-01) NADPH-dependent reductive ortho dehalogenation of 2,4-dichlorobenzoic acid in Corynebacterium sepedonicum KZ-4 and Coryneform bacterium strainNTB-1 via 2,4-dichlorobenzoyl coenzyme A.. Journal of bacteriology, 178 ((9)): (2656-2661). [PMID:8626335]
2. N N Gülerman,E E Oruç,F Kartal,S Rollas. (2000-12-09) In vivo metabolism of 4-fluorobenzoic acid [(5-nitro-2-furanyl)methylene] hydrazide in rats.. European journal of drug metabolism and pharmacokinetics, 25 ((2)): (103-108). [PMID:11112090]
3. L M dos Santos,A Spicq,A P New,G Lo Biundo,J C Wolff,A Edwards. (2001-11-06) Aerobic biotransformation of 4-fluorocinnamic acid to 4-fluorobenzoic acid.. Biodegradation, 12 ((1)): (23-29). [PMID:11693292]
4. Jian Dong,Paul R Carey,Yansheng Wei,Lusong Luo,Xuefeng Lu,Rui-Qin Liu,Debra Dunaway-Mariano. (2002-06-05) Raman evidence for Meisenheimer complex formation in the hydrolysis reactions of 4-fluorobenzoyl- and 4-nitrobenzoyl-coenzyme A catalyzed by 4-chlorobenzoyl-coenzyme A dehalogenase.. Biochemistry, 41 ((23)): (7453-7463). [PMID:12044179]
5. Richard E Carson,Yanjun Wu,Lixin Lang,Ying Ma,Margaret G Der,Peter Herscovitch,William C Eckelman. (2003-02-07) Brain uptake of the acid metabolites of F-18-labeled WAY 100635 analogs.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 23 ((2)): (249-260). [PMID:12571456]
6. Volker Seibert,Monika Thiel,Isabelle-S Hinner,Michael Schlömann. (2004-02-10) Characterization of a gene cluster encoding the maleylacetate reductase from Ralstonia eutropha 335T, an enzyme recruited for growth with 4-fluorobenzoate.. Microbiology (Reading, England), 150 ((Pt 2)): (463-472). [PMID:14766925]
7. M F Carvalho,R Ferreira Jorge,C C Pacheco,P De Marco,P M L Castro. (2005-01-22) Isolation and properties of a pure bacterial strain capable of fluorobenzene degradation as sole carbon and energy source.. Environmental microbiology, 7 ((2)): (294-298). [PMID:15658996]
8. Jan Marik,Julie L Sutcliffe. (2006-08-29) Fully automated preparation of n.c.a. 4-[18F]fluorobenzoic acid and N-succinimidyl 4-[18F]fluorobenzoate using a Siemens/CTI chemistry process control unit (CPCU).. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 65 ((2)): (199-203). [PMID:16935516]
9. Sven H Hausner,Danielle DiCara,Jan Marik,John F Marshall,Julie L Sutcliffe. (2007-08-19) Use of a peptide derived from foot-and-mouth disease virus for the noninvasive imaging of human cancer: generation and evaluation of 4-[18F]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin alphavbeta6 expression with positron emission tomography.. Cancer research, 67 ((16)): (7833-7840). [PMID:17699789]
10. William K Hagmann. (2008-06-24) The many roles for fluorine in medicinal chemistry.. Journal of medicinal chemistry, 51 ((15)): (4359-4369). [PMID:18570365]
11. Hao Pan,Hui Zhou,Su Zeng,Xiao Xu,Haoyun An,Huidi Jiang. (2009-04-21) Identification and simultaneous determination of p-FHA and p-FBA, two metabolites of anti-tumor agent--Fluorapacin in rat urine.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 877 ((14-15)): (1553-1560). [PMID:19376753]
12. Charlotte L Hansen,Bertrand Kuhnast,Franciose Hinnen,Frédéric Dollé,Nic Gillings,Paul R Hansen,Andreas Kjaer. (2009-04-30) Comparison of [18F]FBA and [18F]FPyMe as peptide radiolabeling agents of PEPHC1 for PET imaging of EGFRvIII.. Advances in experimental medicine and biology, 611 (405-406). [PMID:19400242]
13. Sven H Hausner,Craig K Abbey,Richard J Bold,M Karen Gagnon,Jan Marik,John F Marshall,Cathy E Stanecki,Julie L Sutcliffe. (2009-06-25) Targeted in vivo imaging of integrin alphavbeta6 with an improved radiotracer and its relevance in a pancreatic tumor model.. Cancer research, 69 ((14)): (5843-5850). [PMID:19549907]
14. Danilo Pérez-Pantoja,Raúl A Donoso,Miguel A Sánchez,Bernardo González. (2009-08-18) Genuine genetic redundancy in maleylacetate-reductase-encoding genes involved in degradation of haloaromatic compounds by Cupriavidus necator JMP134.. Microbiology (Reading, England), 155 ((Pt 11)): (3641-3651). [PMID:19684066]
15. David Hughes,Benjamin R Clark,Cormac D Murphy. (2010-09-11) Biodegradation of polyfluorinated biphenyl in bacteria.. Biodegradation, 22 ((4)): (741-749). [PMID:20830605]
16. Syed A Hasan,Maria Isabel M Ferreira,Martijn J Koetsier,Muhammad I Arif,Dick B Janssen. (2010-11-26) Complete biodegradation of 4-fluorocinnamic acid by a consortium comprising Arthrobacter sp. strain G1 and Ralstonia sp. strain H1.. Applied and environmental microbiology, 77 ((2)): (572-579). [PMID:21097599]
17. Sharmarke Mohamed,Derek A Tocher,Sarah L Price. (2011-04-19) Computational prediction of salt and cocrystal structures--does a proton position matter?. International journal of pharmaceutics, 418 ((2)): (187-198). [PMID:21497185]
18. Paweł Szymanski,Adam Karpiński,Elzbieta Mikiciuk-Olasik. (2011-05-17) Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors.. European journal of medicinal chemistry, 46 ((8)): (3250-3257). [PMID:21570751]
19. Shih-Yen Wu,Jia-Wei Kuo,Tien-Kuei Chang,Ren-Shen Liu,Rheun-Chuan Lee,Shyh-Jen Wang,Wuu-Jyh Lin,Hsin-Ell Wang. (2012-07-06) Preclinical characterization of 18F-MAA, a novel PET surrogate of 99mTc-MAA.. Nuclear medicine and biology, 39 ((7)): (1026-1033). [PMID:22762865]
20. Junling Li,Rachael L Gerlach,Colleen B Jonsson,Brian D Gray,Koon Y Pak,Chin K Ng. (2014-12-30) Characterization of (18)F-dipicolylamine (DPA) derivatives in cells infected with influenza virus.. Nuclear medicine and biology, 42 ((3)): (283-291). [PMID:25537726]
21. Eleonora von Abercron,Sandy Falk,Thorsten Stahl,Sebastian Georgii,Gerd Hamscher,Hubertus Brunn,Franz Schmitz. (2019-04-17) Determination of adsorbable organically bound fluorine (AOF) and adsorbable organically bound halogens as sum parameters in aqueous environmental samples using combustion ion chromatography (CIC).. The Science of the total environment, 673 (384-391). [PMID:30991328]
22. Julien Andriès,Laëtitia Lemoine,Alice Mouchel-Blaisot,Sandrine Tang,Mathieu Verdurand,Didier Le Bars,Luc Zimmer,Thierry Billard. (2010-05-18) Looking for a 5-HT7 radiotracer for positron emission tomography.. Bioorganic & medicinal chemistry letters, 20 ((12)): (3730-3733). [PMID:20471259]
23. Charlotte Lund Denholt,Tina Binderup,Marie-Thérése Stockhausen,Hans Skovgaard Poulsen,Mogens Spang-Thomsen,Paul Robert Hansen,Nic Gillings,Andreas Kjær. (2011-05-03) Evaluation of 4-[18F]fluorobenzoyl-FALGEA-NH2 as a positron emission tomography tracer for epidermal growth factor receptor mutation variant III imaging in cancer.. Nuclear medicine and biology, 38 ((4)): (509-515). [PMID:21531288]
24. Katarzyna Misiak,Eoin Casey,Cormac D Murphy. (2011-05-04) Factors influencing 4-fluorobenzoate degradation in biofilm cultures of Pseudomonas knackmussii B13.. Water research, 45 ((11)): (3512-3520). [PMID:21536315]
25. Syed A Hasan,Piet Wietzes,Dick B Janssen. (2011-07-06) Biodegradation kinetics of 4-fluorocinnamic acid by a consortium of Arthrobacter and Ralstonia strains.. Biodegradation, 23 ((1)): (117-125). [PMID:21728015]
26. Venkatesha R Hathwar,Tejender S Thakur,Ritesh Dubey,Mysore S Pavan,Tayur N Guru Row,Gautam R Desiraju. (2011-08-04) Extending the supramolecular synthon based fragment approach (SBFA) for transferability of multipole charge density parameters to monofluorobenzoic acids and their cocrystals with isonicotinamide: importance of C-H···O, C-H···F, and F···F intermolecular regions.. The journal of physical chemistry. A, 115 ((45)): (12852-12863). [PMID:21809890]
27. Benjamin J Hackel,Richard H Kimura,Zheng Miao,Hongguang Liu,Ataya Sathirachinda,Zhen Cheng,Frederick T Chin,Sanjiv S Gambhir. (2013-05-15) 18F-fluorobenzoate-labeled cystine knot peptides for PET imaging of integrin αvβ6.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54 ((7)): (1101-1105). [PMID:23670900]
28. Siyuan Chang, Sen Zhang, Tianyi Chen, Lei Xu, Sumin Ge, Bingfeng Li, Chenke Yun, Guoxin Zhang, Xuejun He, Xin Pan. (2023) Efficient synthesis of 5-hydroxymethyl-2-furancarboxylic acid from bio-based high-concentration 5-hydroxymethylfurfural via highly tolerant aldehyde dehydrogenase. Molecular Catalysis, 538 (112966). [PMID:]

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4-Fluoro benzoic acid - 98%, high purity , CAS No.456-22-4