Marker of lipid peroxidation. Prevents NF-κB activation and TNF expression by inhibiting IκB phosphorylation. Range of biological effects such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity. Active in vivo .
Storage Temp
Protected from light,Store at -20°C,Argon charged,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
ACTIVATOR
Mechanism of action
Activator of TRPA1
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description
Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
Associated Targets(Human)
TRPA1TclinTransient receptor potential cation channel subfamily A member 1 (1 Activities)
1.Cao S et al.. (2020) A small-molecule activator of mitochondrial aldehyde dehydrogenase 2 reduces the severity of cerulein-induced acute pancreatitis.. Biochem Biophys Res Commun, 522 (2):(518-524). [PMID:31784085]
2.Niimi N et al.. (2018) A spontaneously immortalized Schwann cell line from aldose reductase-deficient mice as a useful tool for studying polyol pathway and aldehyde metabolism.. J Neurochem, 144 (6):(710-722). [PMID:29238976]
3.Ilari S et al.. (2020) Antioxidant modulation of sirtuin 3 during acute inflammatory pain: The ROS control.. Pharmacol Res, 157 (104851). [PMID:32423865]
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J2331335
