Click Here for 5% Off Your First Aladdin Purchase!

4-Methoxybenzoic acid - 98%, high purity , CAS No.100-09-4

  • ≥98%
Item Number
M104368
Grouped product items
SKUSizeAvailabilityPrice Qty
M104368-25g
25g
In stock
$19.90
M104368-100g
100g
In stock
$23.90
M104368-250g
250g
In stock
$42.90
M104368-500g
500g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$77.90
View related series
Carbonyl compound carboxylic acid

Basic Description

Synonyms4-METHOXYBENZOIC ACID|p-Anisic acid|100-09-4|ANISIC ACID|p-Methoxybenzoic acid|Draconic acid|4-Anisic acid|Benzoic acid, 4-methoxy-|ANISIC ACID, PARA|para-anisic acid|Anisic acid, p-isomer|1335-08-6|P-Methoxy Benzoic Acid|Kyselina 4-methoxybenzoova|4-meth
Specifications & Purity≥98%
Biochemical and Physiological MechanismsMetabolite of aniracetam that mimics its anxiolytic actions. It is also an inhibitor of tyrosinase.
Shipped InNormal
Product Description

4-Methoxybenzoic acid is the sole source of carbon and energy for growth in the cultures of Nocardia sp. DSM 1069.
4-Methoxybenzoic acid was used in oxidation and reduction of cytochrome c in solution through different self-assembled monolayers on gold electrodes using cyclic voltammetry.

Associated Targets

TPMT Tchem Thiopurine S-methyltransferase 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

TAS2R39 Tchem Taste receptor type 2 member 39 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA1 Tclin Carbonic anhydrase 1 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CA2 Tclin Carbonic anhydrase 2 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

CLPP Tchem ATP-dependent Clp protease proteolytic subunit, mitochondrial 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488180453
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488180453
IUPAC Name 4-methoxybenzoic acid
INCHI InChI=1S/C8H8O3/c1-11-7-4-2-6(3-5-7)8(9)10/h2-5H,1H3,(H,9,10)
InChi Key ZEYHEAKUIGZSGI-UHFFFAOYSA-N
Canonical SMILES COC1=CC=C(C=C1)C(=O)O
Isomeric SMILES COC1=CC=C(C=C1)C(=O)O
WGK Germany 1
RTECS BZ4395000
PubChem CID 7478
Molecular Weight 152.15
Beilstein 508910

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

11 results found

Lot NumberCertificate TypeDateItem
B1708036Certificate of AnalysisSep 12, 2024 M104368
H2004018Certificate of AnalysisMay 09, 2024 M104368
F2411275Certificate of AnalysisMay 06, 2024 M104368
F2411277Certificate of AnalysisMay 06, 2024 M104368
E23231264Certificate of AnalysisFeb 02, 2023 M104368
E2323920Certificate of AnalysisFeb 02, 2023 M104368
E2323933Certificate of AnalysisFeb 02, 2023 M104368
E2323934Certificate of AnalysisFeb 02, 2023 M104368
E2323958Certificate of AnalysisFeb 02, 2023 M104368
E2323964Certificate of AnalysisFeb 02, 2023 M104368
A2306243Certificate of AnalysisJan 13, 2023 M104368

more

Chemical and Physical Properties

SolubilityH2O: soluble2500 parts; alcohol: freely soluble; boiling water: soluble; chloroform: freely soluble; diethyl ether: freely soluble; ethyl acetate: freely soluble
SensitivityMoisture sensitive.
Flash Point(°C)185℃
Boil Point(°C)275-280°C
Melt Point(°C)184°C

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H302:Harmful if swallowed

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

WGK Germany 1
RTECS BZ4395000
Merck Index 666

Related Documents

References

1. M Tasaki,Y Kamagata,K Nakamura,E Mikami.  (1992-01-01)  Utilization of methoxylated benzoates and formation of intermediates by Desulfotomaculum thermobenzoicum in the presence or absence of sulfate..  Archives of microbiology,  157  ((3)): (209-212).  [PMID:1510551]
2. H Thoma,J Reiner,G Spiteller.  (1984-07-13)  Profiles of strongly polar and less polar acids obtained from human blood, plasma and serum by two-step ultrafiltration..  Journal of chromatography,  309  ((1)): (17-32).  [PMID:6480763]
3. H Todoriki,T Hayashi,H Naruse.  (1984-10-12)  High-performance liquid chromatographic method for screening disorders of aromatic acid metabolism using a multi-detection system..  Journal of chromatography,  310  ((2)): (273-281).  [PMID:6511847]
4. H G Ibrahim,E S Sallam,M Takieddin,M Habboub.  (1993-05-01)  Effects of solute characteristics and concentration on a lyotropic liquid crystal: solute-induced phase change..  Pharmaceutical research,  10  ((5)): (737-742).  [PMID:8321840]
5. N Dodoff,K Grancharov,N Spassovska.  (1995-12-01)  Platinum(II) complexes of 4-methoxy- and 4-chlorobenzoic acid hydrazides. Synthesis, characterization, and cytotoxic effect..  Journal of inorganic biochemistry,  60  ((4)): (257-266).  [PMID:8530921]
6. T Ogiso,M Iwaki,T Tanino,K Ikeda,T Paku,Y Horibe,H Suzuki.  (1998-05-20)  Pharmacokinetics of aniracetam and its metabolites in rats..  Journal of pharmaceutical sciences,  87  ((5)): (594-598).  [PMID:9572910]
7. S Pauillac,J Naar,P Branaa,M Chinain.  (1998-12-05)  An improved method for the production of antibodies to lipophilic carboxylic hapten using small amount of hapten-carrier conjugate..  Journal of immunological methods,  220  ((1-2)): (105-114).  [PMID:9839931]
8. H Twilfer,G Sandfort,F H Bernhardt.  (2000-09-21)  Substrate and solvent isotope effects on the fate of the active oxygen species in substrate-modulated reactions of putidamonooxin..  European journal of biochemistry,  267  ((19)): (5926-5934).  [PMID:10998052]
9. M Shirane,K Nakamura.  (2001-10-13)  Aniracetam enhances cortical dopamine and serotonin release via cholinergic and glutamatergic mechanisms in SHRSP..  Brain research,  916  ((1-2)): (211-221).  [PMID:11597608]
10. M Wessels,G M König,A D Wright.  (2002-01-05)  New 4-methoxybenzoyl derivatives from the ascidian Polycarpa aurata..  Journal of natural products,  64  ((12)): (1556-1558).  [PMID:11754611]
11. Eyal Shimoni,Timor Baasov,Uzi Ravid,Yuval Shoham.  (2002-01-24)  The trans-anethole degradation pathway in an Arthrobacter sp..  The Journal of biological chemistry,  277  ((14)): (11866-11872).  [PMID:11805095]
12. K Sekar,S Vaijayanthi Mala,M Yogavel,D Velmurugan,Ming-Jye Poi,B S Vishwanath,T V Gowda,A Arokia Jeyaprakash,M-D Tsai.  (2003-10-08)  Crystal structures of the free and anisic acid bound triple mutant of phospholipase A2..  Journal of molecular biology,  333  ((2)): (367-376).  [PMID:14529623]
13. Y Yang,X Li,R Zong,G Liu,W Hu.  (1997-06-01)  [Synthesis and spectroscopic properties of rare earth and p-anisic acid with 1, 10-phenanthroline]..  Guang pu xue yu guang pu fen xi = Guang pu,  17  ((3)): (16-19).  [PMID:15810210]
14. Giulia Caron,Giuseppe Ermondi.  (2005-04-29)  Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk)..  Journal of medicinal chemistry,  48  ((9)): (3269-3279).  [PMID:15857133]
15. Olakunle S Idowu,Abiola O Kolawole,Olajire A Adegoke,Yetunde T Kolade,Adedigbo A Fasanmade,Ajibola A Olaniyi.  (2005-09-13)  Kinetics of thermal decomposition of 4-carboxyl-2,6-dinitrobenzenediazonium ion (CDNBD)..  Journal of AOAC International,  88  ((4)): (1108-1113).  [PMID:16152928]
16. K Sekar,D Gayathri,D Velmurugan,J Jeyakanthan,T Yamane,M J Poi,M D Tsai.  (2006-03-23)  Third calcium ion found in an inhibitor-bound phospholipase A2..  Acta crystallographica. Section D, Biological crystallography,  62  ((Pt 4)): (392-397).  [PMID:16552140]
17. Chao-Bin Xue,Li Zhang,Wan-Chun Luo,Xian-Ye Xie,Lin Jiang,Ting Xiao.  (2007-01-30)  3D-QSAR and molecular docking studies of benzaldehyde thiosemicarbazone, benzaldehyde, benzoic acid, and their derivatives as phenoloxidase inhibitors..  Bioorganic & medicinal chemistry,  15  ((5)): (2006-2015).  [PMID:17258462]
18. Hyunshun Shin,Heather A Gennadios,Douglas A Whittington,David W Christianson.  (2007-02-14)  Amphipathic benzoic acid derivatives: synthesis and binding in the hydrophobic tunnel of the zinc deacetylase LpxC..  Bioorganic & medicinal chemistry,  15  ((7)): (2617-2623).  [PMID:17296300]
19. Patricia Ferreira,Aitor Hernandez-Ortega,Beatriz Herguedas,Angel T Martínez,Milagros Medina.  (2009-07-04)  Aryl-alcohol oxidase involved in lignin degradation: a mechanistic study based on steady and pre-steady state kinetics and primary and solvent isotope effects with two alcohol substrates..  The Journal of biological chemistry,  284  ((37)): (24840-24847).  [PMID:19574215]
20. Souichi Nakashima,Hisashi Matsuda,Yoshimi Oda,Seikou Nakamura,Fengming Xu,Masayuki Yoshikawa.  (2010-03-02)  Melanogenesis inhibitors from the desert plant Anastatica hierochuntica in B16 melanoma cells..  Bioorganic & medicinal chemistry,  18  ((6)): (2337-2345).  [PMID:20189399]
21. Fabrizio Carta,Alessio Innocenti,Rebecca A Hall,Fritz A Mühlschlegel,Andrea Scozzafava,Claudiu T Supuran.  (2011-03-16)  Carbonic anhydrase inhibitors. Inhibition of the β-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with branched aliphatic/aromatic carboxylates and their derivatives..  Bioorganic & medicinal chemistry letters,  21  ((8)): (2521-2526).  [PMID:21402476]
22. Jean J K Bankeu,Rustamova Khayala,Bruno N Lenta,Didérot T Noungoué,Silvère A Ngouela,Sufyan A Mustafa,Khalid Asaad,Mohammed I Choudhary,Sean T Prigge,Ralphreed Hasanov,Augustin E Nkengfack,Etienne Tsamo,Muhammad S Ali.  (2011-05-31)  Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso..  Journal of natural products,  74  ((6)): (1370-1378).  [PMID:21619045]
23. Georgios Papandreou,Kostas Zorpas,Helen Archontaki.  (2011-07-12)  Development and validation of a liquid chromatographic method for the simultaneous determination of aniracetam and its related substances in the bulk drug and a tablet formulation..  Journal of pharmaceutical and biomedical analysis,  56  ((3)): (615-622).  [PMID:21742456]
24. Stephen G Bell,Wen Yang,Adrian B H Tan,Ruimin Zhou,Eachan O D Johnson,Aili Zhang,Weihong Zhou,Zihe Rao,Luet-Lok Wong.  (2012-06-15)  The crystal structures of 4-methoxybenzoate bound CYP199A2 and CYP199A4: structural changes on substrate binding and the identification of an anion binding site..  Dalton transactions (Cambridge, England : 2003),  41  ((28)): (8703-8714).  [PMID:22695988]
25. Antony Gomes,Shamik Bhattacharya,Sanghamitra Mukherjee,Aparna Gomes.  (2012-08-14)  Inhibition of toxic actions of phospholipase A2 isolated & characterized from the Indian Banded Krait (Bungarus fasciatus) venom by synthetic herbal compounds..  The Indian journal of medical research,  136  ((1)): (40-45).  [PMID:22885262]
26. Shutao Guo,C Michael Lin,Zhenghong Xu,Lei Miao,Yuhua Wang,Leaf Huang.  (2014-04-12)  Co-delivery of cisplatin and rapamycin for enhanced anticancer therapy through synergistic effects and microenvironment modulation..  ACS nano,  ((5)): (4996-5009).  [PMID:24720540]
27. Wojciech Ostrowski,Anna Wojakowska,Magdalena Grajzer,Maciej Stobiecki.  (2014-07-27)  Mass spectrometric behavior of phenolic acids standards and their analysis in the plant samples with LC/ESI/MS system..  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences,  967  (21-27).  [PMID:25063924]
28. Mariana C F C B Damião,Kerly F M Pasqualoto,Adilson K Ferreira,Sarah F Teixeira,Ricardo A Azevedo,José A M Barbuto,Fanny Palace-Berl,Gilberto C Franchi-Junior,Alexandre E Nowill,Maurício T Tavares,Roberto Parise-Filho.  (2014-10-07)  Novel capsaicin analogues as potential anticancer agents: synthesis, biological evaluation, and in silico approach..  Archiv der Pharmazie,  347  ((12)): (885-895).  [PMID:25283529]
29. Laurent Mathey,Mitali Paul,Christophe Copéret,Hayato Tsurugi,Kazushi Mashima.  (2015-08-04)  Cerium(IV) Hexanuclear Clusters from Cerium(III) Precursors: Molecular Models for Oxidative Growth of Ceria Nanoparticles..  Chemistry (Weinheim an der Bergstrasse, Germany),  21  ((38)): (13454-13461).  [PMID:26236034]
30. P Xiao,U Staubli,M Kessler,G Lynch.  (1991-10-01)  Selective effects of aniracetam across receptor types and forms of synaptic facilitation in hippocampus..  Hippocampus,  ((4)): (373-380).  [PMID:1688280]
31. U Karlson,D F Dwyer,S W Hooper,E R Moore,K N Timmis,L D Eltis.  (1993-03-01)  Two independently regulated cytochromes P-450 in a Rhodococcus rhodochrous strain that degrades 2-ethoxyphenol and 4-methoxybenzoate..  Journal of bacteriology,  175  ((5)): (1467-1474).  [PMID:8444808]
32. J Lynas,B Walker.  (1997-08-01)  Peptidyl inverse esters of p-methoxybenzoic acid: a novel class of potent inactivator of the serine proteases..  The Biochemical journal,  325 ( Pt 3)  (609-616).  [PMID:9271079]
33. P Martin,I D Wilson.  (1999-01-12)  Comparison of the properties of polymeric and C8 based materials for solid phase extraction..  Journal of pharmaceutical and biomedical analysis,  17  ((6-7)): (1093-1100).  [PMID:9884199]
34. C Gadgoli,S H Mishra.  (1999-08-05)  Antihepatotoxic activity of p-methoxy benzoic acid from Capparis spinosa..  Journal of ethnopharmacology,  66  ((2)): (187-192).  [PMID:10433476]
35. A Hage,H E Schoemaker,J A Field.  (2000-01-05)  Reduction of aryl acids by white-rot fungi for the biocatalytic production of aryl aldehydes and alcohols..  Applied microbiology and biotechnology,  52  ((6)): (834-838).  [PMID:10616717]
36. N Chaves,T Sosa,J C Alías,J C Escudero.  (2001-07-10)  Identification and effects of interaction phytotoxic compounds from exudate of Cistus ladanifer leaves..  Journal of chemical ecology,  27  ((3)): (611-621).  [PMID:11441449]
37. Chika Tateda,Zhongqin Zhang,Jay Shrestha,Joanna Jelenska,Delphine Chinchilla,Jean T Greenberg.  (2014-10-16)  Salicylic acid regulates Arabidopsis microbial pattern receptor kinase levels and signaling..  The Plant cell,  26  ((10)): (4171-4187).  [PMID:25315322]

Solution Calculators