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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Synonyms | 4-methyl-2-oxopentanoic acid | 816-66-0 | 4-Methyl-2-oxovaleric acid | alpha-Ketoisocaproic acid | Ketoleucine | 2-Oxoisocaproate | alpha-ketoisocaproate | 2-OXO-4-METHYLPENTANOIC ACID | Pentanoic acid, 4-methyl-2-oxo- | 4-methyl-2-oxopentanoate | 2-Oxoisocaproic acid | 2-Oxoi |
|---|---|
| Specifications & Purity | Moligand™, 10mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Product Description | An intermediate in the metabolism of leucine. |
Associated Targets(Human)
SLC16A7 Tchem Monocarboxylate transporter 2 (0 Activities)
SLC16A3 Tchem Monocarboxylate transporter 4 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
SLC16A1 Tchem Monocarboxylate transporter 1 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
SLC16A1 Tchem Monocarboxylate transporter 1 (146 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
SLC16A3 Tchem Monocarboxylate transporter 4 (196 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Associated Targets(non-human)
Catharanthus roseus (29 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
|---|
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| IUPAC Name | 4-methyl-2-oxopentanoic acid |
|---|---|
| INCHI | InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9) |
| InChi Key | BKAJNAXTPSGJCU-UHFFFAOYSA-N |
| Canonical SMILES | CC(C)CC(=O)C(=O)O |
| Isomeric SMILES | CC(C)CC(=O)C(=O)O |
| WGK Germany | 3 |
| PubChem CID | 70 |
| UN Number | 3265 |
| Molecular Weight | 130.14 |
| Beilstein | 1701823 |
| Reaxy-Rn | 1701823 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Refractive Index | 1.431 |
|---|---|
| Flash Point(°C) | 83 °C |
| Boil Point(°C) | 85 °C |
| Melt Point(°C) | 8-10°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS05 |
|---|---|
| Signal | Danger |
| Hazard Statements | H314:Causes severe skin burns and eye damage |
| Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately. |
| WGK Germany | 3 |
| Reaxy-Rn | 1701823 |
Related Documents
Citations of This Product
| 1. Xinjian Yin, Yayun Liu, Lijun Meng, Haisheng Zhou, Jianping Wu, Lirong Yang. (2020) Semi-rational hinge engineering: modulating the conformational transformation of glutamate dehydrogenase for enhanced reductive amination activity towards non-natural substrates. Catalysis Science & Technology, 10 (10): (3376-3386). [PMID:] [10.1039/C9CY02576F] |
| 2. Xinjian Yin, Yayun Liu, Lijun Meng, Haisheng Zhou, Jianping Wu, Lirong Yang. (2018) Rational Molecular Engineering of Glutamate Dehydrogenases for Enhancing Asymmetric Reductive Amination of Bulky α-Keto Acids. ADVANCED SYNTHESIS & CATALYSIS, 361 (4): (803-812). [PMID:] [10.1002/adsc.201801251] |
References
| 1. Xinjian Yin, Yayun Liu, Lijun Meng, Haisheng Zhou, Jianping Wu, Lirong Yang. (2020) Semi-rational hinge engineering: modulating the conformational transformation of glutamate dehydrogenase for enhanced reductive amination activity towards non-natural substrates. Catalysis Science & Technology, 10 (10): (3376-3386). [PMID:] [10.1039/C9CY02576F] |
| 2. Xinjian Yin, Yayun Liu, Lijun Meng, Haisheng Zhou, Jianping Wu, Lirong Yang. (2018) Rational Molecular Engineering of Glutamate Dehydrogenases for Enhancing Asymmetric Reductive Amination of Bulky α-Keto Acids. ADVANCED SYNTHESIS & CATALYSIS, 361 (4): (803-812). [PMID:] [10.1002/adsc.201801251] |