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4-P-PDOT - ≥98%, high purity , CAS No.134865-74-0, Antagonist of MT 1 receptor;Antagonist of MT 2 receptor
MT 2 selective melatonin receptor antagonist
Basic Description Synonyms 4-P-PDOT|134865-74-0|4p-PDOT|620170-78-7|cis-4-Phenyl-2-propionamidotetralin|N-(4-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide|N-(4-Phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide|CHEMBL285718|4-phenyl-2- propionamidotetralin|AH 024|4-phenyl Specifications & Purity Moligand™, ≥98% Biochemical and Physiological Mechanisms MT 2 selective melatonin receptor antagonist (K i values are 0.46 and 56 nM for MT 2 and MT 1 respectively). Counteracts melatonin-mediated ERK- and Nrf2-related antioxidant potential in vivo. Source Synthetic Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of MT 1 receptor;Antagonist of MT 2 receptor Note Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Names and Identifiers IUPAC Name N-(4-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide INCHI InChI=1S/C19H21NO/c1-2-19(21)20-16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,2,12-13H2,1H3,(H,20,21) InChi Key RCYLUNPFECYGDW-UHFFFAOYSA-N Canonical SMILES CCC(=O)NC1CC(C2=CC=CC=C2C1)C3=CC=CC=C3 Isomeric SMILES CCC(=O)NC1CC(C2=CC=CC=C2C1)C3=CC=CC=C3 PubChem CID 3976006 Molecular Weight 279.38
Chemical and Physical Properties Solubility Soluble in ethanol to 100 mM and in DMSO to 100 mM Melt Point(°C) 166 °C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
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C23021039