Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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P132032-5g | 5g | In stock | $17.90 | |
P132032-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $26.90 | |
P132032-25g | 25g | In stock | $50.90 | |
P132032-100g | 100g | In stock | $181.90 | |
P132032-500g | 500g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $815.90 |
Synonyms | 4-Phenyl-n-butyrate | CCG-39733 | FT-0673736 | NCGC00018113-04 | NSC295 | NSC-295 | s3592 | gamma-Phenylbutanoic acid | SpecPlus_000814 | CHEBI:41500 | OBKXEAXTFZPCHS-UHFFFAOYSA- | 2-methyl-1-phenyl-propan-2-amine | g-Phenylbutyrate | g-phenyl-Butyrate | |
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Specifications & Purity | Moligand™, ≥99% |
Shipped In | Normal |
Grade | Moligand™ |
Product Description | 4-Phenylbutyric acid (Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and an endoplasmic reticulum stress (ERS) inhibitor. 4-Phenylbutyric acid can be used to treat urea cycle disorders. |
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IUPAC Name | 4-phenylbutanoic acid |
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INCHI | InChI=1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2,(H,11,12) |
InChi Key | OBKXEAXTFZPCHS-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C=C1)CCCC(=O)O |
Isomeric SMILES | C1=CC=C(C=C1)CCCC(=O)O |
WGK Germany | 3 |
Alternate CAS | 1821-12-1,1716-12-7 (hydrochloride) |
PubChem CID | 4775 |
NSC Number | 295 |
MeSH Entry Terms | 4-phenylbutyrate;4-phenylbutyric acid;4-phenylbutyric acid, calcium salt;4-phenylbutyric acid, sodium salt;Ammonaps;Buphenyl;sodium 4-phenylbutanoate;sodium 4-phenylbutyrate;sodium phenylbutyrate |
Molecular Weight | 164.2 |
Beilstein | 9539 |
Reaxy-Rn | 638180 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2417419 | Certificate of Analysis | Jun 11, 2024 | P132032 |
K2113109 | Certificate of Analysis | Aug 17, 2023 | P132032 |
K2113112 | Certificate of Analysis | Aug 17, 2023 | P132032 |
K2113113 | Certificate of Analysis | Aug 17, 2023 | P132032 |
K2113118 | Certificate of Analysis | Aug 17, 2023 | P132032 |
E2411070 | Certificate of Analysis | Jul 25, 2022 | P132032 |
I2202784 | Certificate of Analysis | Jul 25, 2022 | P132032 |
I2202813 | Certificate of Analysis | Jul 25, 2022 | P132032 |
I2202814 | Certificate of Analysis | Jul 25, 2022 | P132032 |
I2202815 | Certificate of Analysis | Jul 25, 2022 | P132032 |
F1828076 | Certificate of Analysis | Feb 15, 2022 | P132032 |
Flash Point(°F) | 230℉ |
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Flash Point(°C) | >110℃ |
Boil Point(°C) | 165℃ |
Melt Point(°C) | 49-53℃ |
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
Reaxy-Rn | 638180 |
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1. Shuanghui Wang, Chuhong Chen, Yan Lu. (2023) Epigallocatechin-3-Gallate Reduces Cd-Induced Developmental Toxicity of Bodysize in Caenorhabditis elegans via the PEK-1/eIF-2α/ATF-4 Pathway. MOLECULES, 28 (17): (6344). [PMID:37687170] [10.3390/molecules28176344] |
2. Chuhong Chen, Ying Deng, Linyan Liu, Zhenyan Zou, Chenzhong Jin, Zhiyin Chen, Shuanghui Wang. (2023) High-Dose Deltamethrin Induces Developmental Toxicity in Caenorhabditis elegans via IRE-1. MOLECULES, 28 (17): (6303). [PMID:37687132] [10.3390/molecules28176303] |
3. Fan Chen, Na Wang, Xinyan Tian, Juan Su, Yan Qin, Rongqiao He, Xiaping He. (2023) The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment. Pharmaceutics, 15 (6): (1568). [PMID:37376018] [10.3390/pharmaceutics15061568] |
4. Lin Zhao, Bingling Zhong, Yanyan Zhu, Haoyi Zheng, Xumei Wang, Ying Hou, Jin-Jian Lu, Nana Ai, Xiuli Guo, Wei Ge, Yan-Yan Ma, Xiuping Chen. (2023) Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1). BIOCHEMICAL PHARMACOLOGY, 210 (115487). [PMID:36893814] [10.1016/j.bcp.2023.115487] |
5. Xiaohui Tan, Dunpeng Cai, Na Chen, Sihao Du, Dongfang Qiao, Xia Yue, Tao Wang, Jia Li, Weibing Xie, Huijun Wang. (2021) Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway. TOXICOLOGY LETTERS, 350 (98). [PMID:34214594] [10.1016/j.toxlet.2021.06.019] |
1. Gardian G, Browne SE, Choi DK, Klivenyi P, Gregorio J, Kubilus JK, Ryu H, Langley B, Ratan RR, Ferrante RJ et al.. (2005) Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease.. J Biol Chem, 280 (1): (556-63). [PMID:15494404] [10.1021/op500134e] |
2. Ryu H, Smith K, Camelo SI, Carreras I, Lee J, Iglesias AH, Dangond F, Cormier KA, Cudkowicz ME, Brown Jr RH et al.. (2005) Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice.. J Neurochem, 93 (5): (1087-98). [PMID:15934930] [10.1021/op500134e] |
3. Iannitti T, Palmieri B. (2011) Clinical and experimental applications of sodium phenylbutyrate.. Drugs R D, 11 (3): (227-49). [PMID:21902286] [10.1021/op500134e] |
4. Shuanghui Wang, Chuhong Chen, Yan Lu. (2023) Epigallocatechin-3-Gallate Reduces Cd-Induced Developmental Toxicity of Bodysize in Caenorhabditis elegans via the PEK-1/eIF-2α/ATF-4 Pathway. MOLECULES, 28 (17): (6344). [PMID:37687170] [10.3390/molecules28176344] |
5. Chuhong Chen, Ying Deng, Linyan Liu, Zhenyan Zou, Chenzhong Jin, Zhiyin Chen, Shuanghui Wang. (2023) High-Dose Deltamethrin Induces Developmental Toxicity in Caenorhabditis elegans via IRE-1. MOLECULES, 28 (17): (6303). [PMID:37687132] [10.3390/molecules28176303] |
6. Fan Chen, Na Wang, Xinyan Tian, Juan Su, Yan Qin, Rongqiao He, Xiaping He. (2023) The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment. Pharmaceutics, 15 (6): (1568). [PMID:37376018] [10.3390/pharmaceutics15061568] |
7. Lin Zhao, Bingling Zhong, Yanyan Zhu, Haoyi Zheng, Xumei Wang, Ying Hou, Jin-Jian Lu, Nana Ai, Xiuli Guo, Wei Ge, Yan-Yan Ma, Xiuping Chen. (2023) Nitrovin (difurazone), an antibacterial growth promoter, induces ROS-mediated paraptosis-like cell death by targeting thioredoxin reductase 1 (TrxR1). BIOCHEMICAL PHARMACOLOGY, 210 (115487). [PMID:36893814] [10.1016/j.bcp.2023.115487] |
8. Xiaohui Tan, Dunpeng Cai, Na Chen, Sihao Du, Dongfang Qiao, Xia Yue, Tao Wang, Jia Li, Weibing Xie, Huijun Wang. (2021) Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway. TOXICOLOGY LETTERS, 350 (98). [PMID:34214594] [10.1016/j.toxlet.2021.06.019] |