4μ8C - 10mM in DMSO, high purity , CAS No.14003-96-4

Item Number

C421493

Grouped product items
SKU	Size	Availability	Price	Qty
C421493-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$241.90

Potent, selective IRE1 Rnase inhibitor

Basic Description

Synonyms	14003-96-4 \| 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde \| 4mu8C \| 4 \| I8C \| IRE1 Inhibitor III \| 7-hydroxy-4-methyl-2-oxochromene-8-carbaldehyde \| 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde \| 2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-4-methyl-2-
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Blocks substrate access to the active site of IRE1α. Inhibits regulated IRE1-dependent degradation (RIDD) and unconventional spicing of Xbp1 mRNA in response to endopasmic reticulum (ER) stress but has no effect on IRE1 kinase activity.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

ERN1 Tchem Serine/threonine-protein kinase/endoribonuclease IRE1 (1682 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

JeKo-1 (376 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	7-hydroxy-4-methyl-2-oxochromene-8-carbaldehyde
INCHI	InChI=1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5,13H,1H3
InChi Key	RTHHSXOVIJWFQP-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=O)OC2=C1C=CC(=C2C=O)O
Isomeric SMILES	CC1=CC(=O)OC2=C1C=CC(=C2C=O)O
WGK Germany	3
PubChem CID	12934390
Molecular Weight	204.18

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed
Precautionary Statements	P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.
WGK Germany	3

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Basic Description