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4μ8C - 10mM in DMSO, high purity , CAS No.14003-96-4
Potent, selective IRE1 Rnase inhibitor
Basic Description Synonyms 14003-96-4 | 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde | 4mu8C | 4 | I8C | IRE1 Inhibitor III | 7-hydroxy-4-methyl-2-oxochromene-8-carbaldehyde | 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde | 2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-4-methyl-2- Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Blocks substrate access to the active site of IRE1α. Inhibits regulated IRE1-dependent degradation (RIDD) and unconventional spicing of Xbp1 mRNA in response to endopasmic reticulum (ER) stress but has no effect on IRE1 kinase activity. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 7-hydroxy-4-methyl-2-oxochromene-8-carbaldehyde INCHI InChI=1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5,13H,1H3 InChi Key RTHHSXOVIJWFQP-UHFFFAOYSA-N Canonical SMILES CC1=CC(=O)OC2=C1C=CC(=C2C=O)O Isomeric SMILES CC1=CC(=O)OC2=C1C=CC(=C2C=O)O WGK Germany 3 PubChem CID 12934390 Molecular Weight 204.18
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
Precautionary Statements P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
WGK Germany 3
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