Potent, selective, cell-permeable STAT3 inhibitor (K d = 880 nM). Inhibits STAT3 dimerization (IC 50 values are 0.28 and 10 μM for STAT3 SH2 domain-mediated ligand binding and STAT1 ligand binding, respectively). Blocks TRAIL-induced invasion.
Storage Temp
Store at 2-8°C,Argon charged
Shipped In
Wet ice
Note
Solvents listed may be unsuitable for use in biological experiments. These solvents are intended to enable solubilisation and mixing of components. We recommend that biologically unsuitable solvents are removed prior to solubilisation in experimental media. Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Associated Targets(Human)
STAT3Tchem Signal transducer and activator of transcription 3 (3313 Activities)
