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A135097-5g

In stock

$33.90

A135097-10g

10g

Available within 4-8 weeks(?)

$59.90

A135097-25g

25g

In stock

$129.90

A135097-100g

100g

In stock

$465.90

Basic Description

Synonyms	NCGC00245975-02 \| 4-amino-5-carbamoylimidazole \| InChI=1/C4H6N4O/c5-3-2(4(6)9)7-1-8-3/h1H,5H2,(H2,6,9)(H,7,8) \| 5-amino-1H-imidazole-4-carboxylic acid amide \| 5-Amino-4-imidazolecarboxamide, 95% \| 5-amino-imidazole-4-carboxamide \| 5-Aminoimidazole-4-carbo
Specifications & Purity	≥95%
Storage Temp	Argon charged
Shipped In	Normal
Product Description	5-Aminoimidazole-4-carboxamide is a metabolite of temozolomide.

Associated Targets(Human)

ATIC Tchem AICAR transformylase (241 Activities)

Discover Target: ATIC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GDA Tbio Guanine deaminase (19 Activities)

Discover Target: GDA

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

U-937 (7138 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KB (17409 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GMNN Tbio Geminin (128009 Activities)

Discover Target: GMNN

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

Discover Target: CBX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TARDBP Tchem TAR DNA-binding protein 43 (40113 Activities)

Discover Target: TARDBP

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488181010
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488181010
IUPAC Name	4-amino-1H-imidazole-5-carboxamide
INCHI	InChI=1S/C4H6N4O/c5-3-2(4(6)9)7-1-8-3/h1H,5H2,(H2,6,9)(H,7,8)
InChi Key	DVNYTAVYBRSTGK-UHFFFAOYSA-N
Canonical SMILES	C1=NC(=C(N1)C(=O)N)N
Isomeric SMILES	C1=NC(=C(N1)C(=O)N)N
WGK Germany	3
RTECS	NI3910000
PubChem CID	9679
Molecular Weight	126.12

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot Number	Certificate Type	Date	Item
L2207436	Certificate of Analysis	Sep 20, 2024	A135097
L2207438	Certificate of Analysis	Sep 20, 2024	A135097
L2207440	Certificate of Analysis	Sep 20, 2024	A135097
A2214272	Certificate of Analysis	Oct 13, 2023	A135097
A2214273	Certificate of Analysis	Oct 13, 2023	A135097
A2214280	Certificate of Analysis	Oct 13, 2023	A135097
D2110234	Certificate of Analysis	Jan 16, 2023	A135097
D2110235	Certificate of Analysis	Jan 16, 2023	A135097
H2307936	Certificate of Analysis	Nov 14, 2022	A135097
L2207437	Certificate of Analysis	Nov 14, 2022	A135097
L2207439	Certificate of Analysis	Nov 14, 2022	A135097

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Chemical and Physical Properties

Solubility	Soluble in DMSO, Methanol, Water.
Melt Point(°C)	164-170°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	NI3910000

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Weixin Kong, Ziwei Chen, Fan Liu, Kexuan Yang, Yao Shen, Shihan Zhang, Wei Li, Sujing Li. (2023) Kinetics of novel non-corrosive amino functionalized ionic liquid organic solution for CO2 capture. SEPARATION AND PURIFICATION TECHNOLOGY, 326 (124749). [PMID:] [10.1016/j.seppur.2023.124749]
2. Yuanling Sun, Rui Han, Yuxue Dai, Xiaodong Zhu, Hao Liu, Dandan Gao, Chuannan Luo, Xueying Wang, Qin Wei. (2019) Highly selective and sensitive streptomycin chemiluminescence sensor based on aptamer and G-quadruplex DNAzyme modified three-dimensional graphene composite. SENSORS AND ACTUATORS B-CHEMICAL, 301 (127122). [PMID:] [10.1016/j.snb.2019.127122]

References

1. Vincent EE et al.. (2014) Differential effects of AMPK agonists on cell growth and metabolism.. Oncogene, [PMID:25241895]
2. Lykke Sylow,Thomas E Jensen,Maximilian Kleinert,Joshua R Mouatt,Stine J Maarbjerg,Jacob Jeppesen,Clara Prats,Tim T Chiu,Shlomit Boguslavsky,Amira Klip,Peter Schjerling,Erik A Richter. (2013-01-01) Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle.. Diabetes, 62 ((4)): (1139-1151). [PMID:23274900]
3. Sofia Theodoropoulou,Katarzyna Brodowska,Maki Kayama,Yuki Morizane,Joan W Miller,Evangelos S Gragoudas,Demetrios G Vavvas. (2013-01-10) Aminoimidazole carboxamide ribonucleotide (AICAR) inhibits the growth of retinoblastoma in vivo by decreasing angiogenesis and inducing apoptosis.. PloS one, 8 ((1)): (e52852-e52852). [PMID:23300996]
4. Junjie Xing,Qilong Wang,Kathleen Coughlan,Benoit Viollet,Cate Moriasi,Ming-Hui Zou. (2013-01-12) Inhibition of AMP-activated protein kinase accentuates lipopolysaccharide-induced lung endothelial barrier dysfunction and lung injury in vivo.. The American journal of pathology, 182 ((3)): (1021-1030). [PMID:23306156]
5. Jang Han Lee,Ji Hyun Kim,Ja Seon Kim,Jai Won Chang,Soon Bae Kim,Jung Sik Park,Sang Koo Lee. (2013-01-18) AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition.. American journal of physiology. Renal physiology, 304 ((6)): (F686-F697). [PMID:23324179]
6. Xiaoliang Cheng,Liping Guo,Zaiquan Li,Liang Li,Tianyan Zhou,Wei Lu. (2013-01-24) A HPLC method for simultaneous determination of 5-aminoimidazole-4-carboxamide riboside and its active metabolite 5-aminoimidazole-4-carboxamide ribotide in tumor-bearing nude mice plasma and its application to pharmacokinetics study.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 915-916 (64-70). [PMID:23340307]
7. Christopher T Banek,Ashley J Bauer,Karen M Needham,Hans C Dreyer,Jeffrey S Gilbert. (2013-02-19) AICAR administration ameliorates hypertension and angiogenic imbalance in a model of preeclampsia in the rat.. American journal of physiology. Heart and circulatory physiology, 304 ((8)): (H1159-H1165). [PMID:23417865]
8. Sang Hyun Kim,Meiko Asaka,Kazuhiko Higashida,Yumiko Takahashi,John O Holloszy,Dong-Ho Han. (2013-02-28) β-Adrenergic stimulation does not activate p38 MAP kinase or induce PGC-1α in skeletal muscle.. American journal of physiology. Endocrinology and metabolism, 304 ((8)): (E844-E852). [PMID:23443926]
9. Renuka N Attanayake,Patrick A Carter,Daohong Jiang,Luis Del Río-Mendoza,Weidong Chen. (2013-03-08) Sclerotinia sclerotiorum populations infecting canola from China and the United States are genetically and phenotypically distinct.. Phytopathology, 103 ((7)): (750-761). [PMID:23464902]
10. Liu Yang,Haibo Sha,Robin L Davisson,Ling Qi. (2013-04-04) Phenformin activates the unfolded protein response in an AMP-activated protein kinase (AMPK)-dependent manner.. The Journal of biological chemistry, 288 ((19)): (13631-13638). [PMID:23548904]
11. Premanand C Sundivakkam,Viswanathan Natarajan,Asrar B Malik,Chinnaswamy Tiruppathi. (2013-04-30) Store-operated Ca2+ entry (SOCE) induced by protease-activated receptor-1 mediates STIM1 protein phosphorylation to inhibit SOCE in endothelial cells through AMP-activated protein kinase and p38β mitogen-activated protein kinase.. The Journal of biological chemistry, 288 ((23)): (17030-17041). [PMID:23625915]
12. Stephen P Ray,Nathan Duval,Terry G Wilkinson,Sean E Shaheen,Kingshuk Ghosh,David Patterson. (2013-05-30) Inherent properties of adenylosuccinate lyase could explain S-Ado/SAICAr ratio due to homozygous R426H and R303C mutations.. Biochimica et biophysica acta, 1834 ((8)): (1545-1553). [PMID:23714113]
13. Nicola E Clarke,Nikolai D Belyaev,Daniel W Lambert,Anthony J Turner. (2013-10-24) Epigenetic regulation of angiotensin-converting enzyme 2 (ACE2) by SIRT1 under conditions of cell energy stress.. Clinical science (London, England : 1979), 126 ((7)): (507-516). [PMID:24147777]
14. Anja Grabke,Dolores Fernández-Ortuño,Achour Amiri,Xingpeng Li,Natália A Peres,Powell Smith,Guido Schnabel. (2013-10-26) Characterization of iprodione resistance in Botrytis cinerea from strawberry and blackberry.. Phytopathology, 104 ((4)): (396-402). [PMID:24156554]
15. Mohammad M Al-bataineh,Fan Gong,Allison L Marciszyn,Michael M Myerburg,Núria M Pastor-Soler. (2014-02-21) Regulation of proximal tubule vacuolar H(+)-ATPase by PKA and AMP-activated protein kinase.. American journal of physiology. Renal physiology, 306 ((9)): (F981-F995). [PMID:24553431]
16. Takashi Sasaki,Rieko Nakata,Hiroyasu Inoue,Makoto Shimizu,Jun Inoue,Ryuichiro Sato. (2014-03-20) Role of AMPK and PPARγ1 in exercise-induced lipoprotein lipase in skeletal muscle.. American journal of physiology. Endocrinology and metabolism, 306 ((9)): (E1085-E1092). [PMID:24644240]
17. Richard D Weisel,Nancy Nussmeier,Mark F Newman,Ronald G Pearl,Andrew S Wechsler,Giuseppe Ambrosio,Bertram Pitt,Robert M Clare,Karen S Pieper,Linda Mongero,Tammy L Reece,Terrence M Yau,Stephen Fremes,Philippe Menasché,Armando Lira,Robert A Harrington,T Bruce Ferguson. (2014-09-15) Predictors of contemporary coronary artery bypass grafting outcomes.. The Journal of thoracic and cardiovascular surgery, 148 ((6)): (2720-2726). [PMID:25218533]
18. Genlai Li,Wen Yao,Honglin Jiang. (2014-10-17) Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue.. The Journal of nutrition, 144 ((12)): (1887-1895). [PMID:25320182]
19. Naoya Nakai,Fuminori Kawano,Ken Nakata. (2015-05-15) Mechanical stretch activates mammalian target of rapamycin and AMP-activated protein kinase pathways in skeletal muscle cells.. Molecular and cellular biochemistry, 406 ((1-2)): (285-292). [PMID:25971373]
20. Shun Takeo,Takahito Abe,Koumei Shirasuna,Takehito Kuwayama,Hisataka Iwata. (2015-05-24) Effect of 5-aminoimidazole-4-carboxamide ribonucleoside on the mitochondrial function and developmental ability of bovine oocytes.. Theriogenology, 84 ((4)): (490-497). [PMID:26001600]
21. Teraneh Z Jhaveri,Juhyung Woo,Xiaobin Shang,Ben Ho Park,Edward Gabrielson. (2015-07-06) AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer.. Oncotarget, 6 ((17)): (14754-14765). [PMID:26143491]
22. Joanna Matysiak,Małgorzata Juszczak,Monika M Karpińska,Ewa Langner,Katarzyna Walczak,Marta Lemieszek,Alicja Skrzypek,Wojciech Rzeski,Andrzej Niewiadomy. (2015-07-21) Synthesis, characterization, and pharmacological evaluation of novel azolo- and azinothiazinones containing 2,4-dihydroxyphenyl substituent as anticancer agents.. Monatshefte fur chemie, 146 ((8)): (1315-1327). [PMID:26190864]
23. Lucas Willmann,Thalia Erbes,Sebastian Halbach,Tilman Brummer,Markus Jäger,Marc Hirschfeld,Tanja Fehm,Hans Neubauer,Elmar Stickeler,Bernd Kammerer. (2015-08-22) Exometabolom analysis of breast cancer cell lines: Metabolic signature.. Scientific reports, 5 (13374-13374). [PMID:26293811]
24. Hiroyasu Hatakeyama,Makoto Kanzaki. (2013-01-18) Regulatory mode shift of Tbc1d1 is required for acquisition of insulin-responsive GLUT4-trafficking activity.. Molecular biology of the cell, 24 ((6)): (809-817). [PMID:23325788]
25. Melissa A Burmeister,Jennifer Ayala,Daniel J Drucker,Julio E Ayala. (2013-01-24) Central glucagon-like peptide 1 receptor-induced anorexia requires glucose metabolism-mediated suppression of AMPK and is impaired by central fructose.. American journal of physiology. Endocrinology and metabolism, 304 ((7)): (E677-E685). [PMID:23341495]
26. James P White,Melissa J Puppa,Song Gao,Shuichi Sato,Stephen L Welle,James A Carson. (2013-03-28) Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK.. American journal of physiology. Endocrinology and metabolism, 304 ((10)): (E1042-E1052). [PMID:23531613]
27. Melania Collu-Marchese,Michael Shuen,Marion Pauly,Ayesha Saleem,David A Hood. (2015-07-17) The regulation of mitochondrial transcription factor A (Tfam) expression during skeletal muscle cell differentiation.. Bioscience reports, 35 ((3)): [PMID:26182383]
28. Hui Lin,Nianshuang Li,Huan He,Ying Ying,Shashank Sunkara,Lingyu Luo,Nonghua Lv,Deqiang Huang,Zhijun Luo. (2015-10-02) AMPK Inhibits the Stimulatory Effects of TGF-β on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition.. Molecular pharmacology, 88 ((6)): (1062-1071). [PMID:26424816]
29. Weixin Kong, Ziwei Chen, Fan Liu, Kexuan Yang, Yao Shen, Shihan Zhang, Wei Li, Sujing Li. (2023) Kinetics of novel non-corrosive amino functionalized ionic liquid organic solution for CO2 capture. SEPARATION AND PURIFICATION TECHNOLOGY, 326 (124749). [PMID:] [10.1016/j.seppur.2023.124749]
30. Yuanling Sun, Rui Han, Yuxue Dai, Xiaodong Zhu, Hao Liu, Dandan Gao, Chuannan Luo, Xueying Wang, Qin Wei. (2019) Highly selective and sensitive streptomycin chemiluminescence sensor based on aptamer and G-quadruplex DNAzyme modified three-dimensional graphene composite. SENSORS AND ACTUATORS B-CHEMICAL, 301 (127122). [PMID:] [10.1016/j.snb.2019.127122]

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5-Amino-4-imidazolecarboxamide - 95%, high purity , CAS No.360-97-4

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Show more⌵

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator