5-Aza-2′-deoxycytidine - 98%, high purity , DNA (cytosine-5)-methyltransferase 1 inhibitor, CAS No.2353-33-5, DNA (cytosine-5)-methyltransferase 1 inhibitor

Item Number
A119533
Grouped product items
SKUSizeAvailabilityPrice Qty
A119533-5mg
5mg
In stock
$18.90
A119533-25mg
25mg
In stock
$70.90
A119533-100mg
100mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$215.90
A119533-500mg
500mg
In stock
$970.90
A119533-1g
1g
In stock
$1,746.90
A119533-5g
5g
In stock
$7,860.90

Potent DNMT1 inhibitor. Induces DNA hypomethylation.

Basic Description

Synonyms2-deoxyazacytidine | 5-Aza-2'-deoxycytidine, >=97% | 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one | 2'-desoxy-5-azacytidine | 2-Desoxy-5-azacytidine | E-7373 | MLS006010136 | NSC127716 | NSC-127716 | DECITABINE (MART.) | DECITABIN
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological Mechanisms5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcripti
Storage TempStore at 2-8°C,Argon charged
Shipped InWet ice
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionDNA (cytosine-5)-methyltransferase 1 inhibitor
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.

Associated Targets(Human)

DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR2 Tclin Vasopressin V2 receptor (2912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CACNA1C Tclin Voltage-gated L-type calcium channel alpha-1C subunit (766 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC29A1 Tclin Equilibrative nucleoside transporter 1 (1711 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA2A Tclin Adenosine A2a receptor (16305 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA3 Tchem Adenosine A3 receptor (15931 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DNMT1 Tclin DNA (cytosine-5)-methyltransferase 1 (978 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
BDKRB2 Tclin Bradykinin B2 receptor (3970 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH3 Tclin Histamine H3 receptor (10389 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRNA4 Tclin Neuronal acetylcholine receptor protein alpha-4 subunit (1265 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MC3R Tchem Melanocortin receptor 3 (5659 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

ampC Beta-lactamase AmpC (62480 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mc4r Melanocortin receptor 4 (1205 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Npy1r Neuropeptide Y receptor type 1 (8 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cckar Cholecystokinin A receptor (90 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Human immunodeficiency virus 1 (70413 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
L1210 (27553 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P388 (20296 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
P388/ADR (1216 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
H4 (48 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Giardia (1682 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Nfe2l2 Nuclear factor erythroid 2-related factor 2 (214 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488189867
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488189867
IUPAC Name 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one
INCHI InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1
InChi Key XAUDJQYHKZQPEU-KVQBGUIXSA-N
Canonical SMILES C1C(C(OC1N2C=NC(=NC2=O)N)CO)O
Isomeric SMILES C1[C@@H]([C@H](O[C@H]1N2C=NC(=NC2=O)N)CO)O
WGK Germany 3
RTECS XZ3012000
PubChem CID 451668
Molecular Weight 228.21
Beilstein 617982

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

17 results found

Lot NumberCertificate TypeDateItem
B2328469Certificate of AnalysisJan 07, 2023 A119533
B2328478Certificate of AnalysisJan 07, 2023 A119533
B2328477Certificate of AnalysisJan 07, 2023 A119533
B2328476Certificate of AnalysisJan 07, 2023 A119533
B2328475Certificate of AnalysisJan 07, 2023 A119533
B2328474Certificate of AnalysisJan 07, 2023 A119533
B2328473Certificate of AnalysisJan 07, 2023 A119533
B2328472Certificate of AnalysisJan 07, 2023 A119533
B2328471Certificate of AnalysisJan 07, 2023 A119533
B2328470Certificate of AnalysisJan 07, 2023 A119533
B2328468Certificate of AnalysisJan 07, 2023 A119533
I1813151Certificate of AnalysisJul 19, 2022 A119533
E2212130Certificate of AnalysisMay 18, 2022 A119533
D1803112Certificate of AnalysisFeb 19, 2022 A119533
J2323106Certificate of AnalysisOct 26, 2021 A119533
D2110228Certificate of AnalysisApr 17, 2021 A119533
D2110229Certificate of AnalysisApr 17, 2021 A119533

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Chemical and Physical Properties

Sensitivitylight sensitive;heat sensitive
Melt Point(°C)191 °C(dec.)

Safety and Hazards(GHS)

Pictogram(s) GHS08,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H341:Suspected of causing genetic defects

H302:Harmful if swallowed

H360:May damage fertility or the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P281:Use personal protective equipment as required.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P317:IF SWALLOWED: Get medical help.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS XZ3012000
Merck Index 2853

Related Documents

Citations of This Product

1. Jiahao Hu, Yuchan You, Luwen Zhu, Jucong Zhang, Yanling Song, Jingyi Lu, Xinyi Xu, Xiaochuan Wu, Xiajie Huang, Xiaoling Xu, Yongzhong Du.  (2023)  Sialic Acid-Functionalized Pyroptosis Nanotuner for Epigenetic Regulation and Enhanced Cancer Immunotherapy.  Small,    (15): (2306905).  [PMID:37880861] [10.1002/smll.202306905]
2. Shuoyi Zhang, Ming Zhong, Hongbo Zhu, Qinghua You, Hao Yuan, Yongping Li.  (2023)  Hypomethylation of DRD2 promotes breast cancer through the FLNA-ERK pathway.  Cancer Genetics,      [PMID:37729778] [10.1016/j.cancergen.2023.09.001]
3. Weichu Zhu, Jian Xu, Xianxian Yao, Shuting Mai, Dan Shu, Wuli Yang.  (2023)  Metal–organic-framework-based pyroptosis nanotuner with long blood circulation for augmented chemotherapy.  Biomaterials Science,      [PMID:37470092] [10.1039/D3BM00813D]
4. An Yaqian, Yu Zhiqi, Liu Di, Han Lirong, Zhang Xian, Xin Xuelian, Li Cuiping.  (2023)  HpaII-assisted and linear amplification-enhanced isothermal exponential amplification fluorescent strategy for rapid and sensitive detection of DNA methyltransferase activity.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  415  (12): (2271-2280).  [PMID:36961574] [10.1007/s00216-023-04647-1]
5. Fan Du, Ting Jin, Li Wang.  (2023)  Mechanism of Action of Decitabine in the Treatment of Acute Myeloid Leukemia by Regulating LINC00599.  Analytical Cellular Pathology,  2023  (2951519).  [PMID:36874552] [10.1155/2023/2951519]
6. Hailin Yu, Huili Zhang, Xin Wei, Yong Chen, Bo Yu, Yingjun Wang, Hongsheng Liu.  (2023)  Preparation of a cationic block copolymer composite coagulant TP(AM-DAC-PPFS) and its coagulation performance for treating oilfield sewage.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,  171  (341).  [PMID:] [10.1016/j.psep.2022.12.060]
7. Tong Gao, Xiao Sang, Xinyan Huang, Panpan Gu, Jie Liu, Yongjun Liu, Na Zhang.  (2022)  Macrophage-camouflaged epigenetic nanoinducers enhance chemoimmunotherapy in triple negative breast cancer.  Acta Pharmaceutica Sinica B,      [PMID:37799382] [10.1016/j.apsb.2022.11.018]
8. Shi Guang, Feng Juan, Jian Ling-Yan, Fan Xin-Yu.  (2022)  DNA hypomethylation promotes learning and memory recovery in a rat model of cerebral ischemia/reperfusion injury.  Neural Regeneration Research,  18  (4): (863).  [PMID:36204855] [10.4103/1673-5374.353494]
9. Duan Houyu, Ding Xiang, Luo Hesheng.  (2022)  KISS-1, Mediated by Promoter Methylation, Suppresses Esophageal Squamous Cell Carcinoma Metastasis via MMP2/9/MAPK Axis.  DIGESTIVE DISEASES AND SCIENCES,  67  (10): (4780-4796).  [PMID:34993679] [10.1007/s10620-021-07335-1]
10. Peng Yi, Xiongfeng Xu, Jiawei Yao, Bo Qiu.  (2021)  Effect of DNA methylation on gene transcription is associated with the distribution of methylation sites across the genome in osteoarthritis.  Experimental and Therapeutic Medicine,  22  (1): (1-8).  [PMID:34007328] [10.3892/etm.2021.10151]
11. Yafei Wang, Huimin Liu, Jianmin Wu, Yunjian Liao, Daifeng Lu, Feng Dong, Hongxi Li, Zhitao Zhang, Yongyun Lian.  (2020)  5-Aza-2-deoxycytidine inhibits osteolysis induced by titanium particles by regulating RANKL/OPG ratio.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,  529  (629).  [PMID:32736684] [10.1016/j.bbrc.2020.05.192]
12. Mengmeng Shu, Shijun Long, Yiwan Huang, Dapeng Li, Haiyan Li, Xuefeng Li.  (2019)  High strength and antibacterial polyelectrolyte complex CS/HS hydrogel films for wound healing.  Soft Matter,  15  (38): (7686-7694).  [PMID:31498364] [10.1039/C9SM01380F]
13. Li Zhang, Xiaofen Xiao, Yuzhi Xu, Danping Chen, Jun Chen, Yingjun Ma, Zong Dai, Xiaoyong Zou.  (2018)  Electrochemical assay for continuous monitoring of dynamic DNA methylation process.  BIOSENSORS & BIOELECTRONICS,  100  (184).  [PMID:28889069] [10.1016/j.bios.2017.08.013]
14. Qing Wang, Pu Wang, Hong Zhou, Yan Hu, Chengshen Xie, Fei Gao, Ningjie Ma, Haoli Hou, Hao Zhang, Lijia Li.  (2017)  5-Azacytidine specifically inhibits the NIH-3T3 PCD process induced by TNF-alpha and cycloheximide via affecting BCL-XL.  JOURNAL OF CELLULAR BIOCHEMISTRY,  119  (2): (1501-1510).  [PMID:28777484] [10.1002/jcb.26310]
15. Jing Yin, Feilong Zhu, Weiyu Hao, Qi Xu, Jin Chang, Huili Wang, Baoyuan Guo.  (2017)  Acylamino acid chiral fungicides on toxiciepigenetics in lambda DNA methylation.  FOOD AND CHEMICAL TOXICOLOGY,  109  (735).  [PMID:28456568] [10.1016/j.fct.2017.04.038]
16. Yongjun Sun, Chengyu Zhu, Wenquan Sun, Yanhua Xu, Xuefeng Xiao, Huaili Zheng, Huifang Wu, Cuiyun Liu.  (2017)  Plasma-initiated polymerization of chitosan-based CS-g-P(AM-DMDAAC) flocculant for the enhanced flocculation of low-algal-turbidity water.  CARBOHYDRATE POLYMERS,  164  (222).  [PMID:28325320] [10.1016/j.carbpol.2017.02.010]

References

1. Jones PA, Taylor SM.  (1980)  Cellular differentiation, cytidine analogs and DNA methylation..  Cell,  20  (1): (85-93).  [PMID:6156004] [10.1021/op500134e]
2. Moujalled DM et al..  (2019)  Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia..  Leukemia,  33  (4): (905-917).  [PMID:30214012]
3. Niebel D et al..  (2022)  DNA methylation regulates TIGIT expression within the melanoma microenvironment, is prognostic for overall survival, and predicts progression-free survival in patients treated with anti-PD-1 immunotherapy..  Clin Epigenetics,  14  (50).  [PMID:35410311]
4. Evans MR et al..  (2019)  Human Papillomavirus 16 E2 Regulates Keratinocyte Gene Expression Relevant to Cancer and the Viral Life Cycle..  J Virol,  93  (4):   [PMID:30518656]
5. Zeng X et al..  (2018)  Secreted Frizzled Related Protein 2 Modulates Epithelial-Mesenchymal Transition and Stemness via Wnt/ß-Catenin Signaling in Choriocarcinoma..  Cell Physiol Biochem,  50  (5): (1815-1831).  [PMID:30396168]
6. Mulati K et al..  (2019)  VISTA expressed in tumour cells regulates T cell function..  Br J Cancer,  120  (115-127).  [PMID:30382166]
7. Jiahao Hu, Yuchan You, Luwen Zhu, Jucong Zhang, Yanling Song, Jingyi Lu, Xinyi Xu, Xiaochuan Wu, Xiajie Huang, Xiaoling Xu, Yongzhong Du.  (2023)  Sialic Acid-Functionalized Pyroptosis Nanotuner for Epigenetic Regulation and Enhanced Cancer Immunotherapy.  Small,    (15): (2306905).  [PMID:37880861] [10.1002/smll.202306905]
8. Shuoyi Zhang, Ming Zhong, Hongbo Zhu, Qinghua You, Hao Yuan, Yongping Li.  (2023)  Hypomethylation of DRD2 promotes breast cancer through the FLNA-ERK pathway.  Cancer Genetics,      [PMID:37729778] [10.1016/j.cancergen.2023.09.001]
9. Weichu Zhu, Jian Xu, Xianxian Yao, Shuting Mai, Dan Shu, Wuli Yang.  (2023)  Metal–organic-framework-based pyroptosis nanotuner with long blood circulation for augmented chemotherapy.  Biomaterials Science,      [PMID:37470092] [10.1039/D3BM00813D]
10. An Yaqian, Yu Zhiqi, Liu Di, Han Lirong, Zhang Xian, Xin Xuelian, Li Cuiping.  (2023)  HpaII-assisted and linear amplification-enhanced isothermal exponential amplification fluorescent strategy for rapid and sensitive detection of DNA methyltransferase activity.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  415  (12): (2271-2280).  [PMID:36961574] [10.1007/s00216-023-04647-1]
11. Fan Du, Ting Jin, Li Wang.  (2023)  Mechanism of Action of Decitabine in the Treatment of Acute Myeloid Leukemia by Regulating LINC00599.  Analytical Cellular Pathology,  2023  (2951519).  [PMID:36874552] [10.1155/2023/2951519]
12. Hailin Yu, Huili Zhang, Xin Wei, Yong Chen, Bo Yu, Yingjun Wang, Hongsheng Liu.  (2023)  Preparation of a cationic block copolymer composite coagulant TP(AM-DAC-PPFS) and its coagulation performance for treating oilfield sewage.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,  171  (341).  [PMID:] [10.1016/j.psep.2022.12.060]
13. Tong Gao, Xiao Sang, Xinyan Huang, Panpan Gu, Jie Liu, Yongjun Liu, Na Zhang.  (2022)  Macrophage-camouflaged epigenetic nanoinducers enhance chemoimmunotherapy in triple negative breast cancer.  Acta Pharmaceutica Sinica B,      [PMID:37799382] [10.1016/j.apsb.2022.11.018]
14. Shi Guang, Feng Juan, Jian Ling-Yan, Fan Xin-Yu.  (2022)  DNA hypomethylation promotes learning and memory recovery in a rat model of cerebral ischemia/reperfusion injury.  Neural Regeneration Research,  18  (4): (863).  [PMID:36204855] [10.4103/1673-5374.353494]
15. Duan Houyu, Ding Xiang, Luo Hesheng.  (2022)  KISS-1, Mediated by Promoter Methylation, Suppresses Esophageal Squamous Cell Carcinoma Metastasis via MMP2/9/MAPK Axis.  DIGESTIVE DISEASES AND SCIENCES,  67  (10): (4780-4796).  [PMID:34993679] [10.1007/s10620-021-07335-1]
16. Peng Yi, Xiongfeng Xu, Jiawei Yao, Bo Qiu.  (2021)  Effect of DNA methylation on gene transcription is associated with the distribution of methylation sites across the genome in osteoarthritis.  Experimental and Therapeutic Medicine,  22  (1): (1-8).  [PMID:34007328] [10.3892/etm.2021.10151]
17. Yafei Wang, Huimin Liu, Jianmin Wu, Yunjian Liao, Daifeng Lu, Feng Dong, Hongxi Li, Zhitao Zhang, Yongyun Lian.  (2020)  5-Aza-2-deoxycytidine inhibits osteolysis induced by titanium particles by regulating RANKL/OPG ratio.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,  529  (629).  [PMID:32736684] [10.1016/j.bbrc.2020.05.192]
18. Mengmeng Shu, Shijun Long, Yiwan Huang, Dapeng Li, Haiyan Li, Xuefeng Li.  (2019)  High strength and antibacterial polyelectrolyte complex CS/HS hydrogel films for wound healing.  Soft Matter,  15  (38): (7686-7694).  [PMID:31498364] [10.1039/C9SM01380F]
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Solution Calculators