5-Aza-2′-deoxycytidine - 98%, high purity , DNA (cytosine-5)-methyltransferase 1 inhibitor, CAS No.2353-33-5, DNA (cytosine-5)-methyltransferase 1 inhibitor

Item Number

A119533

• Synonyms: 2-deoxyazacytidine | 5-Aza-2'-deoxycytidine, >=97% | 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-s-triazin-2(1H)-one | 2'-desoxy-5-azacytidine | 2-Desoxy-5-azacytidine | E-7373 | MLS006010136 | NSC127716 | NSC-127716 | DECITABINE (MART.) | DECITABIN
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: 5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcripti
• Storage Temp: Store at 2-8°C,Argon charged
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: DNA (cytosine-5)-methyltransferase 1 inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.