5-Chloro-8-hydroxy-7-iodoquinoline - >98.0%(T), high purity , Iron chelating agent, CAS No.130-26-7, Iron chelating agent

2 Citations
  • ≥98%(T)
Item Number
C123531
Grouped product items
SKUSizeAvailabilityPrice Qty
C123531-10g
10g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$17.90
C123531-25g
25g
In stock
$34.90
C123531-50g
50g
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$61.90

Metal chelator and ionophore

Basic Description

SynonymsIodochlorhydroxyquin | Iodochlorhydroxyquin Cream | Vioform-Hydrocortisone Mild | Enteroquinol | NSC-74938 | Quinoform | Chloro-8-hydroxyiodoquinoline | Cortin | Formtone-HC | 5-Chlor-7-jod-8-hydroxy-chinolin [German] | 7-Iodo-5-chloro-8-hydroxyquinoline
Specifications & Purity≥98%(T)
Biochemical and Physiological MechanismsMetal chelator and ionophore with beneficial effects in animal models of neurodegenerative diseases (Alzheimer's, Parkinson's and Huntington's disease).
Storage TempProtected from light,Argon charged
Shipped InNormal
Action TypeCHELATING AGENT
Mechanism of actionIron chelating agent
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Clioquinol is a member of the hydroxyquinoline family which inhibits certain enzymes related to DNA replication. Clioquinol is a metal chelating ligand which displays protective effects in various neurodegenerative states as well as being a component in antifungal and antiprotozoal agents. It has been shown to modulate amyloid beta-peptide accumulation via upregulation of metalloprotease activity. When co-administered with vitamin B12, Clioquinol rescues lead-induced impairments of synaptic plasticity in an animal models. In recent animal studies Clioquinol has shown to reverse the progression of Parkinson's, Alzheimer's, and Huntington's diseases. Clioquinol has been observed to induce apoptosis in human cancer cell lines by generating free zinc in lysosomes.
A metal chelating ligand that inhibits certain enzymes related to DNA replication.

Product Properties

ALogP3.5

Associated Targets(Human)

CYP1A2 Tchem Cytochrome P450 1A2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
F2 Tclin Thrombin (11687 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA2 Tclin Carbonic anhydrase II (17698 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ESR1 Tclin Estrogen receptor alpha (17718 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NR3C1 Tclin Glucocorticoid receptor (14987 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PGR Tclin Progesterone receptor (8562 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
VDR Tclin Vitamin D receptor (26531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD2 Tclin Dopamine D2 receptor (23596 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOA Tclin Monoamine oxidase A (11911 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD1 Tclin Dopamine D1 receptor (9720 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
COMT Tclin Catechol O-methyltransferase (404 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ACHE Tclin Acetylcholinesterase (18204 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A2 Tclin Norepinephrine transporter (10102 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH2 Tclin Histamine H2 receptor (5428 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MAOB Tclin Monoamine oxidase B (8835 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADORA1 Tclin Adenosine A1 receptor (17603 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A4 Tclin Serotonin transporter (12625 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HRH1 Tclin Histamine H1 receptor (7573 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRM1 Tclin Mu opioid receptor (19785 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DRD3 Tclin Dopamine D3 receptor (14368 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PPARG Tclin Peroxisome proliferator-activated receptor gamma (15191 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRD1 Tclin Delta opioid receptor (15096 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
OPRK1 Tclin Kappa opioid receptor (16155 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR3A Tclin Serotonin 3a (5-HT3a) receptor (3366 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SLC6A3 Tclin Dopamine transporter (10535 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PTH1R Tclin Parathyroid hormone receptor (47172 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GRIN1 Tclin Glutamate (NMDA) receptor subunit zeta 1 (122 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE3A Tclin Phosphodiesterase 3A (3309 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2B Tclin Alpha-2b adrenergic receptor (4412 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
ADRA2C Tclin Alpha-2c adrenergic receptor (4876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CHRM3 Tclin Muscarinic acetylcholine receptor M3 (7750 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RXRA Tclin Retinoid X receptor alpha (3637 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PDE4A Tclin Phosphodiesterase 4A (1943 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA3 Tclin Carbonic anhydrase III (753 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA6 Tclin Carbonic anhydrase VI (993 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA1 Tclin Carbonic anhydrase I (13240 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Ca7 Carbonic anhydrase VII (3 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ttr Transthyretin (14 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp13 Matrix metalloproteinase 13 (19 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cruzipain (33337 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pde4d Phosphodiesterase 4D (4 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ppard Peroxisome proliferator-activated receptor delta (358 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Ca13 Carbonic anhydrase XIII (322 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CA4 Carbonic anhydrase IV (1713 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mapk1 MAP kinase ERK2 (650 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp2 Matrix metalloproteinase-2 (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mmp9 Matrix metalloproteinase 9 (38 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichophyton benhamiae (1686 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Klebsiella pneumoniae (43867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella typhimurium (15756 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plesiomonas shigelloides (58 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Micrococcus luteus (7463 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus epidermidis (22802 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Citrobacter freundii (1864 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Morganella morganii (1291 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella enteritidis (727 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Serratia marcescens (3237 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Shigella dysenteriae (933 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aeromonas hydrophila (292 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus niger (16508 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus subtilis (32866 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Clostridium acetobutylicum (18 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Listeria monocytogenes (2626 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Pneumocystis carinii (749 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Saccharomyces cerevisiae (19171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Enterococcus faecalis (29875 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Bacillus cereus (7522 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Corynebacterium diphtheriae (64 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cutibacterium acnes (887 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Aspergillus oryzae (433 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania infantum (5912 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei (78846 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trypanosoma brucei brucei (13300 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Entamoeba histolytica (2676 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cryptosporidium parvum (1150 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Tetrahymena thermophila (42 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Albifimbria verrucaria (26 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida (1648 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Candida albicans (78123 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Trichoderma viride (1263 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Leishmania amazonensis (3813 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 5-chloro-7-iodoquinolin-8-ol
INCHI InChI=1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChi Key QCDFBFJGMNKBDO-UHFFFAOYSA-N
Canonical SMILES C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1
Isomeric SMILES C1=CC2=C(C(=C(C=C2Cl)I)O)N=C1
WGK Germany 3
RTECS VC5075000
PubChem CID 2788
Molecular Weight 305.5
Beilstein 153637
Reaxy-Rn 153637

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

11 results found

Lot NumberCertificate TypeDateItem
F2206171Certificate of AnalysisMar 20, 2024 C123531
K2303127Certificate of AnalysisOct 20, 2023 C123531
K2303128Certificate of AnalysisOct 20, 2023 C123531
I2107347Certificate of AnalysisJun 15, 2023 C123531
I2010075Certificate of AnalysisJul 21, 2022 C123531
F2206120Certificate of AnalysisMay 13, 2022 C123531
F2206139Certificate of AnalysisMay 13, 2022 C123531
F2206313Certificate of AnalysisMay 13, 2022 C123531
J2323086Certificate of AnalysisMay 13, 2022 C123531
C2330374Certificate of AnalysisSep 11, 2021 C123531
I2107348Certificate of AnalysisSep 11, 2021 C123531

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Chemical and Physical Properties

SolubilitySoluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)).
SensitivityLight sensitive;Air sensitive
Melt Point(°C)175°C

Safety and Hazards(GHS)

Pictogram(s) GHS06,   GHS08,   GHS09,   GHS07
Signal Danger
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

H301:Toxic if swallowed

H400:Very toxic to aquatic life

H372:Causes damage to organs through prolonged or repeated exposure

H361fd:Suspected of damaging fertility; Suspected of damaging the unborn child

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P260:Do not breathe dust/fume/gas/mist/vapors/spray.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P391:Collect spillage.

P330:Rinse mouth.

P203:Obtain, read and follow all safety instructions before use.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P301+P316:IF SWALLOWED: Get emergency medical help immediately.

P318:if exposed or concerned, get medical advice.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
RTECS VC5075000
Reaxy-Rn 153637
Merck Index 5031

Related Documents

Citations of This Product

1. Qin Tan, Xuanxuan An, Shuang Pan, Shujun Zhen, Yongmei Hu, Xiaoli Hu.  (2022)  One-pot hydrothermal method synthesis carbon dots as a fluorescent sensor for the sensitive and selective detection of clioquinol.  OPTICAL MATERIALS,  123  (111830).  [PMID:]
2. Lijun Xu, Jialin Sai, Dongguo Xue, Lu Zhou, Renjun Pei, Aihua Liu.  (2021)  Amplified Peroxidase-like Activity of Co2+ Using 8-Hydroxyquinoline and Its Application for Ultrasensitive Colorimetric Detection of Clioquinol.  Chemistry-An Asian Journal,  16  (23): (3957-3962).  [PMID:34605211]

References

1. Santana L et al..  (2008)  Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors..  J Med Chem,  51  (21): (6740-51).  [PMID:18834112]
2. T W Meade.  (1975-09-01)  Subacute myelo-optic neuropathy and clioquinol. An epidemiological case-history for diagnosis..  British journal of preventive & social medicine,  29  ((3)): (157-169).  [PMID:127638]
3. C Chen,K Samejima,Z Tamura.  (1976-01-01)  A gas chromatographic determination method of 5-chloro-7-iodo-8-quinolinol and its conjugates in biological fluids..  Chemical & pharmaceutical bulletin,  24  ((1)): (97-101).  [PMID:131650]
4. H E Kaeser.  (1984-01-01)  Transient global amnesia due to clioquinol..  Acta neurologica Scandinavica. Supplementum,  100  (175-183).  [PMID:6237545]
5. J Tateishi.  (2000-10-19)  Subacute myelo-optico-neuropathy: clioquinol intoxication in humans and animals..  Neuropathology : official journal of the Japanese Society of Neuropathology,  20 Suppl  (S20-S24).  [PMID:11037182]
6. Vincent Moret,Nathalie Dereudre-Bosquet,Pascal Clayette,Younes Laras,Nicolas Pietrancosta,Amandine Rolland,Clement Weck,Sylvain Marc,Jean-Louis Kraus.  (2006-09-27)  Synthesis and anti-HIV properties of new hydroxyquinoline-polyamine conjugates on cells infected by HIV-1 LAV and HIV-1 BaL viral strains..  Bioorganic & medicinal chemistry letters,  16  ((23)): (5988-5992).  [PMID:17000109]
7. Poonpilas Hongmanee,Kamolchanok Rukseree,Benjamas Buabut,Boontiwa Somsri,Prasit Palittapongarnpim.  (2006-12-21)  In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis..  Antimicrobial agents and chemotherapy,  51  ((3)): (1105-1106).  [PMID:17178795]
8. Brian Y Feng,Brandon H Toyama,Holger Wille,David W Colby,Sean R Collins,Barnaby C H May,Stanley B Prusiner,Jonathan Weissman,Brian K Shoichet.  (2008-01-29)  Small-molecule aggregates inhibit amyloid polymerization..  Nature chemical biology,  ((3)): (197-199).  [PMID:18223646]
9. Noriyoshi Iwata.  (2008-04-22)  [Therapeutic effect of clioquinol for Alzheimer disease]..  Nihon yakurigaku zasshi. Folia pharmacologica Japonica,  131  ((3)): (223-223).  [PMID:18421848]
10. Vincent Moret,Younes Laras,Thierry Cresteil,Geneviève Aubert,Dou Q Ping,Chen Di,Magali Barthélémy-Requin,Christophe Béclin,Vincent Peyrot,Diane Allegro,Amandine Rolland,Francesca De Angelis,Evelina Gatti,Philippe Pierre,Luca Pasquini,Eleonora Petrucci,Ugo Testa,Jean-Louis Kraus.  (2008-05-20)  Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: synthesis, structure-activity relationship, and action mechanism studies..  European journal of medicinal chemistry,  44  ((2)): (558-567).  [PMID:18485536]
11. Alessio Innocenti,Mika Hilvo,Andrea Scozzafava,Seppo Parkkila,Claudiu T Supuran.  (2008-05-27)  Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols..  Bioorganic & medicinal chemistry letters,  18  ((12)): (3593-3596).  [PMID:18501600]
12. Xinliang Mao,Aaron D Schimmer.  (2008-09-25)  The toxicology of Clioquinol..  Toxicology letters,  182  ((1-3)): (1-6).  [PMID:18812216]
13. Denis Fourches,Julie C Barnes,Nicola C Day,Paul Bradley,Jane Z Reed,Alexander Tropsha.  (2009-12-18)  Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species..  Chemical research in toxicology,  23  ((1)): (171-183).  [PMID:20014752]
14. Naomi L Kruhlak,Sydney S Choi,Joseph F Contrera,James L Weaver,James M Willard,Kenneth L Hastings,Lawrence F Sancilio.  (2008-01-01)  Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models..  Toxicology mechanisms and methods,  18  ((2-3)): (217-227).  [PMID:20020916]
15. Francisco J Prado-Prado,Xerardo García-Mera,Humberto González-Díaz.  (2010-02-27)  Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species..  Bioorganic & medicinal chemistry,  18  ((6)): (2225-2231).  [PMID:20185316]
16. A D Schimmer.  (2011-01-21)  Clioquinol - a novel copper-dependent and independent proteasome inhibitor..  Current cancer drug targets,  11  ((3)): (325-331).  [PMID:21247386]
17. Amy M Ruschak,Malik Slassi,Lewis E Kay,Aaron D Schimmer.  (2011-05-25)  Novel proteasome inhibitors to overcome bortezomib resistance..  Journal of the National Cancer Institute,  103  ((13)): (1007-1017).  [PMID:21606441]
18. Claudia C Wagner,Ana C González-Baró,Enrique J Baran.  (2011-06-15)  Vibrational spectra of the Ga(III) complexes with oxine and clioquinol..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  79  ((5)): (1762-1765).  [PMID:21664859]
19. Kouichi Yoshinari,Mariko Sakamoto,Laddawan Senggunprai,Yasushi Yamazoe.  (2011-08-09)  Clioquinol is sulfated by human jejunum cytosol and SULT1A3, a human-specific dopamine sulfotransferase..  Toxicology letters,  206  ((2)): (229-233).  [PMID:21820498]
20. Jie Zheng,Doris M Benbrook,Haijun Yu,Wei-Qun Ding.  (2011-08-27)  Clioquinol suppresses cyclin D1 gene expression through transcriptional and post-transcriptional mechanisms..  Anticancer research,  31  ((9)): (2739-2747).  [PMID:21868515]
21. Agnieszka Zgoła-Grześkowiak,Tomasz Grześkowiak.  (2011-09-29)  The use of a triple quadrupole linear ion trap mass spectrometer with electrospray ionisation for fragmentation studies of selected antifungal drugs..  Rapid communications in mass spectrometry : RCM,  25  ((20)): (3049-3055).  [PMID:21953959]
22. Peter Faller.  (2011-11-29)  Copper in Alzheimer disease: too much, too little, or misplaced?.  Free radical biology & medicine,  52  ((4)): (747-748).  [PMID:22120895]
23. Jie Zheng,Xiao-Xi Zhang,Haijun Yu,Jori E Taggart,Wei-Qun Ding.  (2012-03-15)  Zinc at cytotoxic concentrations affects posttranscriptional events of gene expression in cancer cells..  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology,  29  ((1-2)): (181-188).  [PMID:22415087]
24. []}].  (2013-04-06)  Can we reverse Alzheimer's? New approaches from Harvard offer hope..  Harvard health letter,  38  ((3)): (1-1).  [PMID:23556155]
25. Biyin Cao,Jie Li,Jingyu Zhu,Mingyun Shen,Kunkun Han,Zubin Zhang,Yang Yu,Yali Wang,Depei Wu,Suning Chen,Aining Sun,Xiaowen Tang,Yun Zhao,Chunhua Qiao,Tingjun Hou,Xinliang Mao.  (2013-10-12)  The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity..  The Journal of biological chemistry,  288  ((47)): (34181-34189).  [PMID:24114842]
26. Marin J de Jong,Judith J Korterink,Marc A Benninga,Mirrian Hilbink,J Widdershoven,Judith M Deckers-Kocken.  (2014-07-24)  Dientamoeba fragilis and chronic abdominal pain in children: a case-control study..  Archives of disease in childhood,  99  ((12)): (1109-1113).  [PMID:25053737]
27. Takao Fukui,Kunihiko Asakura,Chika Hikichi,Tomomasa Ishikawa,Rie Murai,Seiko Hirota,Ken-Ichiro Murate,Madoko Kizawa,Akihiro Ueda,Shinji Ito,Tatsuro Mutoh.  (2015-03-12)  Histone deacetylase inhibitor attenuates neurotoxicity of clioquinol in PC12 cells..  Toxicology,  331  (112-118).  [PMID:25758465]
28. Richard M Monaghan,Robert G Barnes,Kate Fisher,Tereza Andreou,Nicholas Rooney,Gino B Poulin,Alan J Whitmarsh.  (2015-05-12)  A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity..  Nature cell biology,  17  ((6)): (782-792).  [PMID:25961505]
29. Maria Carmen Catapano,Michele Protti,Tommaso Fontana,Roberto Mandrioli,Přemysl Mladěnka,Laura Mercolini.  (2019-08-28)  An Original HPLC Method with Coulometric Detection to Monitor Hydroxyl Radical Generation via Fenton Chemistry..  Molecules (Basel, Switzerland),  24  ((17)):   [PMID:31450723]
30. F Clifford Rose,M Gawel.  (1984-01-01)  Clioquinol neurotoxicity: an overview..  Acta neurologica Scandinavica. Supplementum,  100  (137-145).  [PMID:6237543]
31. R J List,E P Flook,H L Tay.  (2011-07-07)  Tympanoplasty graft preparation using ear drops containing polyethylene glycol, flumethasone and clioquinol..  The Journal of laryngology and otology,  125  ((8)): (853-855).  [PMID:21729449]
32. Omonike Olaleye,Tirumalai R Raghunand,Shridhar Bhat,Curtis Chong,Peihua Gu,Jiangbing Zhou,Ying Zhang,William R Bishai,Jun O Liu.  (2011-11-26)  Characterization of clioquinol and analogues as novel inhibitors of methionine aminopeptidases from Mycobacterium tuberculosis..  Tuberculosis (Edinburgh, Scotland),  91 Suppl 1  (S61-S65).  [PMID:22115541]
33. Amy R Cameron,Katherine Wallace,Lisa Logie,Alan R Prescott,Terry G Unterman,Jean Harthill,Graham Rena.  (2012-01-18)  The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a..  The Biochemical journal,  443  ((1)): (57-64).  [PMID:22248233]
34. Mudhafar K Murad,Stig Larsen,Hans Husum.  (2012-02-07)  Prehospital trauma care reduces mortality. Ten-year results from a time-cohort and trauma audit study in Iraq..  Scandinavian journal of trauma, resuscitation and emergency medicine,  20  (13-13).  [PMID:22304808]
35. Masato Katsuyama,Kazumi Iwata,Masakazu Ibi,Kuniharu Matsuno,Misaki Matsumoto,Chihiro Yabe-Nishimura.  (2012-05-26)  Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling..  Toxicology,  299  ((1)): (55-59).  [PMID:22627294]
36. Aaron D Schimmer,Yulia Jitkova,Marcela Gronda,Zezhou Wang,Joseph Brandwein,Christine Chen,Vikas Gupta,Andre Schuh,Karen Yee,Jian Chen,Suzanne Ackloo,Tristan Booth,Sharon Keays,Mark D Minden.  (2012-06-12)  A phase I study of the metal ionophore clioquinol in patients with advanced hematologic malignancies..  Clinical lymphoma, myeloma & leukemia,  12  ((5)): (330-336).  [PMID:22683301]
37. J W Loock.  (2012-07-19)  A randomised controlled trial of active chronic otitis media comparing courses of eardrops versus one-off topical treatments suitable for primary, secondary and tertiary healthcare settings..  Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery,  37  ((4)): (261-270).  [PMID:22804826]
38. Tomohiro M Oyama,Shiro Ishida,Yoshiro Okano,Hakaru Seo,Yasuo Oyama.  (2012-10-10)  Clioquinol-induced increase and decrease in the intracellular Zn2+ level in rat thymocytes..  Life sciences,  91  ((23-24)): (1216-1220).  [PMID:23044228]
39. Jin Hee Kim,Bong Geom Jang,Bo Young Choi,Lyo Min Kwon,Min Sohn,Hong Ki Song,Sang Won Suh.  (2012-11-03)  Zinc chelation reduces hippocampal neurogenesis after pilocarpine-induced seizure..  PloS one,  ((10)): (e48543-e48543).  [PMID:23119054]
40. Janna M A Ter Schure,Marrit de Vries,Jan F L Weel,Eric N van Roon,Tina E Faber.  (2012-11-30)  Symptoms and treatment of Dientamoeba fragilis infection in children, a retrospective study..  The Pediatric infectious disease journal,  32  ((4)): (e148-e150).  [PMID:23190787]
41. Kazuyuki Kawamura,Yukiko Kuroda,Masako Sogo,Miki Fujimoto,Toshio Inui,Takao Mitsui.  (2014-04-24)  Superoxide dismutase as a target of clioquinol-induced neurotoxicity..  Biochemical and biophysical research communications,  452  ((1)): (181-185).  [PMID:24755073]
42. Joon Seo Lim,Gou Young Koh,Jae-Young Koh.  (2014-12-03)  Angiopoietin-1 blocks neurotoxic zinc entry into cortical cells via PIP2 hydrolysis-mediated ion channel inhibition..  Neurobiology of disease,  81  (203-213).  [PMID:25447223]
43. Douglas R Langbehn.  (2014-12-04)  Criteria for success in safety and tolerability trials..  The Lancet. Neurology,  14  ((1)): (24-25).  [PMID:25467849]
44. Turan Yildiz,Zekeriya Ilce,Muzaffer Yildirim,Mehmet Akdogan,Yusuf Yurumez,Onursal Varlikli,Fatma Husniye Dilek.  (2015-02-02)  Antienflamatuar and antiadhesive effect of clioquinol..  International journal of surgery (London, England),  15  (17-22).  [PMID:25638731]
45. Bo-Ra Seo,Sook-Jeong Lee,Kyung Sook Cho,Young Hee Yoon,Jae-Young Koh.  (2015-10-11)  The zinc ionophore clioquinol reverses autophagy arrest in chloroquine-treated ARPE-19 cells and in APP/mutant presenilin-1-transfected Chinese hamster ovary cells..  Neurobiology of aging,  36  ((12)): (3228-3238).  [PMID:26453000]
46. Qin Tan, Xuanxuan An, Shuang Pan, Shujun Zhen, Yongmei Hu, Xiaoli Hu.  (2022)  One-pot hydrothermal method synthesis carbon dots as a fluorescent sensor for the sensitive and selective detection of clioquinol.  OPTICAL MATERIALS,  123  (111830).  [PMID:]
47. Lijun Xu, Jialin Sai, Dongguo Xue, Lu Zhou, Renjun Pei, Aihua Liu.  (2021)  Amplified Peroxidase-like Activity of Co2+ Using 8-Hydroxyquinoline and Its Application for Ultrasensitive Colorimetric Detection of Clioquinol.  Chemistry-An Asian Journal,  16  (23): (3957-3962).  [PMID:34605211]

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