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5-cyclopropyl-6-(2,6-dimethylpyridin-4-yl)-N-[(3R,4R)-3-fluoro-1-methylpiperidin-4-yl]-1H-indazol-3-amine , CAS No.C608758, Antagonist of TLR8

5-cyclopropyl-6-(2,6-dimethylpyridin-4-yl)-N-[(3R,4R)-3-fluoro-1-methylpiperidin-4-yl]-1H-indazol-3-amine , CAS No.C608758, Antagonist of TLR8

Item Number

C608758

Grouped product items
SKU	Size	Availability	Price	Qty
C608758-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C608758-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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Basic Description

TLR8 Tchem Toll-like receptor 8 (0 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

INCHI	InChI=1S/C23H28FN5/c1-13-8-16(9-14(2)25-13)18-11-22-19(10-17(18)15-4-5-15)23(28-27-22)26-21-6-7-29(3)12-20(21)24/h8-11,15,20-21H,4-7,12H2,1-3H3,(H2,26,27,28)/t20-,21-/m1/s1
InChi Key	PNGWZDXPZBZBRC-NHCUHLMSSA-N
Canonical SMILES	C1(CC1)c1cc2c(n[nH]c2cc1c1cc(nc(c1)C)C)N[C@H]1[C@@H](CN(CC1)C)F
PubChem CID	163358783

PubChem CID	163358783

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1. Betschart C, Faller M, Zink F, Hemmig R, Blank J, Vangrevelinghe E, Bourrel M, Glatthar R, Behnke D, Barker K et al.. (2022) Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist.. ACS Med Chem Lett, 13 (4): (658-664). [PMID:35450354] [10.1021/op500134e]

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