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5-Ethynyl-2'-deoxyuridine (EdU) , CAS No.61135-33-9
Metaboling Labeling reagents
Basic Description Synonyms 5-Ethynyl-2'-deoxyuridine, (EdU), AldrichCPR | AC-32360 | 5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione | 5-Ethynyl-2'-deoxyuridine | 5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2 Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description 5-Ethynyl-2_-deoxyuridine (EdU) is a thymidine analog that can be incorporated into replicating DNA for detection of cell proliferations. The alkyne handler can be used for subsequent ligation to azide-containing molecules through a highly efficient click chemistry reaction.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione INCHI InChI=1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h1,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s1 InChi Key CDEURGJCGCHYFH-DJLDLDEBSA-N Canonical SMILES C#CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)O Isomeric SMILES C#CC1=CN(C(=O)NC1=O)[C@H]2C[C@@H]([C@H](O2)CO)O WGK Germany 3 PubChem CID 472172 Molecular Weight 252.22
Chemical and Physical Properties Specific Rotation[α] [α]D：23° (C=0.7,MeOH) Melt Point(°C) 199 °C
Safety and Hazards(GHS) Pictogram(s) GHS08 Signal Danger Hazard Statements H340: May cause genetic defects
H361: Suspected of damaging fertility or the unborn child
Precautionary Statements P280: Wear protective gloves/protective clothing/eye protection/face protection.
P405: Store locked up.
P501: Dispose of contents/container to ...
P281: Use personal protective equipment as required.
P203: Obtain, read and follow all safety instructions before use.
P318: if exposed or concerned, get medical advice.
WGK Germany 3
Citations of This Product 1. Xianke Zhou, Yadie Xiang, Dier Li, Menghua Zhong, Xue Hong, Yuan Gui, Wenjian Min, Yudan Chen, Xi Zeng, Haili Zhu, Youhua Liu, Shijia Liu, Peng Yang, Fanfan Hou, Dong Zhou, Haiyan Fu. (2023) Limonin, a natural ERK2 agonist, protects against ischemic acute kidney injury. International Journal of Biological Sciences, 19 (9): ( 2860–2878). [PMID:37324945 ] [10.7150/ijbs.82417 ] 2. Zhang Jing, Liang Lijia, Guan Xin, Deng Rong, Qu Huixin, Huang Dianshuai, Xu Shuping, Liang Chongyang, Xu Weiqing. (2018) In situ, accurate, surface-enhanced Raman scattering detection of cancer cell nucleus with synchronous location by an alkyne-labeled biomolecular probe. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (2): (585-594). [PMID:29214531 ] [10.1007/s00216-017-0761-4 ]
References 1. Xianke Zhou, Yadie Xiang, Dier Li, Menghua Zhong, Xue Hong, Yuan Gui, Wenjian Min, Yudan Chen, Xi Zeng, Haili Zhu, Youhua Liu, Shijia Liu, Peng Yang, Fanfan Hou, Dong Zhou, Haiyan Fu. (2023) Limonin, a natural ERK2 agonist, protects against ischemic acute kidney injury. International Journal of Biological Sciences, 19 (9): ( 2860–2878). [PMID:37324945 ] [10.7150/ijbs.82417 ] 2. Zhang Jing, Liang Lijia, Guan Xin, Deng Rong, Qu Huixin, Huang Dianshuai, Xu Shuping, Liang Chongyang, Xu Weiqing. (2018) In situ, accurate, surface-enhanced Raman scattering detection of cancer cell nucleus with synchronous location by an alkyne-labeled biomolecular probe. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (2): (585-594). [PMID:29214531 ] [10.1007/s00216-017-0761-4 ]
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