5-Ethynyluridine (5-EU) - ≥99%, high purity , CAS No.69075-42-9

  • ≥99%
Item Number
E276476
Grouped product items
SKUSizeAvailabilityPrice Qty
E276476-10mg
10mg
In stock
$1,329.90
E276476-100mg
100mg
In stock
$205.90
E276476-250mg
250mg
In stock
$343.90
E276476-1g
1g
In stock
$1,029.90

Uridine analog. Click chemistry RNA transcription label.

Basic Description

Synonyms5-EU | AKOS024462949 | 5-ethynyl uridine | DS-8002 | EX-A3665 | GLXC-25273 | AC-32359 | QCWBIPKYTBFWHH-FDDDBJFASA-N | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-ethynylpyrimidine-2,4-dione | 5-Ethynyl Uridine (EU) | C76184 | Uridine, 5
Specifications & Purity≥99%
Biochemical and Physiological MechanismsUridine analog. Click chemistry RNA transcription label. Incorporates into RNA during active RNA synthesis. Does not incorporate into DNA. Reacts with azide-containing detection reagents.
Storage TempProtected from light,Store at -20°C,Argon charged,Desiccated
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.

Associated Targets(non-human)

Pseudomonas aeruginosa (123386 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Salmonella typhimurium (15756 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Escherichia coli (133304 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium avium (4587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mycobacterium tuberculosis (203094 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488198755
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488198755
IUPAC Name 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-ethynylpyrimidine-2,4-dione
INCHI InChI=1S/C11H12N2O6/c1-2-5-3-13(11(18)12-9(5)17)10-8(16)7(15)6(4-14)19-10/h1,3,6-8,10,14-16H,4H2,(H,12,17,18)/t6-,7-,8-,10-/m1/s1
InChi Key QCWBIPKYTBFWHH-FDDDBJFASA-N
Canonical SMILES C#CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
Isomeric SMILES C#CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
PubChem CID 14885960
Molecular Weight 268.22

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
B2301684Certificate of AnalysisFeb 01, 2024 E276476
B2301672Certificate of AnalysisNov 08, 2023 E276476
B2301852Certificate of AnalysisNov 08, 2023 E276476
B2301858Certificate of AnalysisNov 08, 2023 E276476
B2301881Certificate of AnalysisNov 08, 2023 E276476

Chemical and Physical Properties

SolubilitySoluble in PBS and water to 200 mM (with heating)
Sensitivityair sensitive; light sensitive;Moisture sensitive

Related Documents

References

1. Perea-Resa C et al..  (2020)  Cohesin Removal Reprograms Gene Expression upon Mitotic Entry..  Mol Cell,  78  (127-140.e7).  [PMID:32035037]
2. Prusty AB et al..  (2017)  Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation..  J Cell Biol,  216  (8): (2391-2407).  [PMID:28637748]
3. Pavlova NN et al..  (2020)  Translation in amino-acid-poor environments is limited by tRNAGln charging..  Elife,    [PMID:33289483]

Solution Calculators