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5-Fluoro-2′-deoxyuridine - 99%, high purity , Thymidylate synthase inhibitor, CAS No.50-91-9, Thymidylate synthase inhibitor

Moligand™

≥99%

CAS#: 50-91-9
Formula: C₉H₁₁FN₂O₅
Molecular Weight: 246.19
MDL number: MFCD00006530
PubChem CID: 5790

Item Number

F110732

Grouped product items
SKU	Size	Availability	Price
F110732-250mg	250mg	In stock	$142.90
F110732-1g	1g	In stock	$426.90
F110732-5g	5g	In stock	$1,919.90
F110732-25g	25g	In stock	$8,638.90

Prodrug. Antimetabolite antineoplastic agent.

View related series

Pyrimidines Six-Membered Heterocyclic Compounds

Basic Description

Synonyms	floxuridine \| 50-91-9 \| 5-Fluorodeoxyuridine \| 2'-Deoxy-5-fluorouridine \| Fluorodeoxyuridine \| FUDR \| Floxuridin \| FdUrd \| 5-Fluoro-2'-deoxyuridine \| Deoxyfluorouridine \| Fluoruridine deoxyribose \| 5FdU \| Floxiridina \| Floxuridinum \| 5-Fluoro-2-desoxyuridine \| 5-Fluorouracil 2'-deoxyr
Specifications & Purity	Moligand™, ≥99%
Biochemical and Physiological Mechanisms	Antineoplastic drug that acts as a potent inhibitor of thymidylate synthetase Resistance to FUdR can develop in cancer cell cultures, among other means, by low-level Mycoplasma infection.Prodrug. Antimetabolite antineoplastic agent. Shows more potent anti
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Thymidylate synthase inhibitor
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	5-Fluoro-2′-deoxyuridine, also called floxuridine elicits DNA-directed cytotoxicity in cancer cells. Floxuridine is effective for treating liver cancer and eliminating virulence of Staphylococcus aureus. Dipeptide prodrugs combination of floxuridine with gemcitabine are more cell permeable and display enhanced anti-proliferative activity. Floxuridine is effective on solid tumours and advanced stage cancers. 5-Fluoro-2′-deoxyuridine has been used as a mitotic inhibitor in schwann cell proliferation, glia proliferation and nonneuronal cells in dorsal root ganglion cultures.

Product Properties

ALogP	-1.2

Associated Targets(non-human)

TK Thymidine kinase (276 Activities)

Discover Target: TK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mc4r Melanocortin receptor 4 (1205 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Ltc4s Leukotriene C4 synthase (1 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sigmar1 Sigma opioid receptor (160 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cckar Cholecystokinin A receptor (90 Activities)

Discover Target: Cckar

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

deoA Thymidine phosphorylase (531 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mapk1 MAP kinase ERK2 (650 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Streptococcus (3973 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus aureus (210822 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Staphylococcus epidermidis (22802 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Escherichia coli (133304 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Streptococcus sp. (212 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Streptococcus pyogenes (16140 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Enterococcus faecium (13803 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Cryptosporidium parvum (1150 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Plasmodium falciparum (966862 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Toxoplasma gondii (4585 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Human alphaherpesvirus 2 (4932 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Human respirovirus 3 (1674 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mus musculus (284745 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vaccinia virus (4609 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Human alphaherpesvirus 1 (11089 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hepatitis B virus (7925 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sindbis virus (1599 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vesicular stomatitis virus (4460 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Punta Toro virus (1491 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Coxsackievirus B4 (2249 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Respiratory syncytial virus (3434 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Duck hepatitis B virus (235 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Streptococcus sp. 'group A' (3417 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CCRF S-180 (1031 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

FM3A (1296 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

L1210 (27553 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

L5178Y (1809 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MEF (1005 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P388 (20296 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

P388/ADR (1216 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Sarcoma-180 (387 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Vero (26788 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

NIH3T3 (5395 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KBALB cell line (25 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

L929 (3802 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BALB/3T3 (534 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
INCHI	InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChi Key	ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Canonical SMILES	C1C(C(OC1N2C=C(C(=O)NC2=O)F)CO)O
Isomeric SMILES	C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)F)CO)O
RTECS	YU7525000
PubChem CID	5790
UN Number	1760
Packing Group	I
Molecular Weight	246.19
Reaxy-Rn	90221

Database links

DrugBank Ligand	DB00322
CAS Registry No.	50-91-9
Wikipedia	Floxuridine
PubChem CID	5790
ChEMBL Ligand	CHEMBL917
DrugCentral Ligand	1184

Certificates

Certificate of Analysis(COA)

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To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

15 results found

Lot Number	Certificate Type	Date	Item
G2425402	Certificate of Analysis	Mar 30, 2024	F110732
G2425403	Certificate of Analysis	Mar 30, 2024	F110732
H2309307	Certificate of Analysis	Jul 21, 2023	F110732
H2309311	Certificate of Analysis	Jul 21, 2023	F110732
H2309313	Certificate of Analysis	Jul 21, 2023	F110732
H2309314	Certificate of Analysis	Jul 21, 2023	F110732
H2309317	Certificate of Analysis	Jul 21, 2023	F110732
H2309321	Certificate of Analysis	Jul 21, 2023	F110732
H2309322	Certificate of Analysis	Jul 21, 2023	F110732
H2309323	Certificate of Analysis	Jul 21, 2023	F110732
F1904109	Certificate of Analysis	Mar 17, 2023	F110732
I2214489	Certificate of Analysis	Aug 09, 2022	F110732
I2214492	Certificate of Analysis	Aug 09, 2022	F110732
I2214493	Certificate of Analysis	Aug 09, 2022	F110732
I2214494	Certificate of Analysis	Aug 09, 2022	F110732

Chemical and Physical Properties

Solubility	Soluble in water, alcohol, isopropyl alcohol, methanol, aqueous buffers, acetone, dimethyl sulfoxide, and ethanol. Insoluble in ether, benzene and chloroform.
Sensitivity	heat sensitive
Specific Rotation[α]	38 ° (C=1, H2O)
Melt Point(°C)	148°C

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08
Signal	Danger
Hazard Statements	H301:Toxic if swallowed H341:Suspected of causing genetic defects
Precautionary Statements	P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P318:if exposed or concerned, get medical advice.
RTECS	YU7525000
Reaxy-Rn	90221
Class	8
Merck Index	4112

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FAQ

Nucleotide Synthesis in Cancer Cells

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nucleotide Glycolysis Ribose 5-phosphate TCA cycle

Citations of This Product

1. Tao Long, Xue Chen, Yue Zhang, Yu-Jia Zhou, Yan-Ni He, Yun-Fei Zhu, Hai-Jun Fu, Lu Yu, Chong-Lin Yu, Betty Yuen-Kwan Law, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu, Xiao-Gang Zhou. (2023) Protective effects of Radix Stellariae extract against Alzheimer's disease via autophagy activation in Caenorhabditis elegans and cellular models. BIOMEDICINE & PHARMACOTHERAPY, 165 (115261). [PMID:37549461]
2. Yong-Jun Huang, Xiao-Lin Zhong, Yi-Peng Zang, Ming-Han Yang, Jing Lin, Wei-Min Chen. (2023) 3-Hydroxy-pyridin-4(1H)-ones as siderophores mediated delivery of isobavachalcone enhances antibacterial activity against pathogenic Pseudomonas aeruginosa. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 257 (115454). [PMID:37210837]
3. Tisong Liang, Jiexin Zhou, Pu Jing, Zhengjun He, Shunshan Jiao, Wenji Zhao, Qi Tong, Guofu Jia. (2023) Anti-senescence effects of Rhodiola crenulate extracts on LO2 cells and bioactive compounds. JOURNAL OF ETHNOPHARMACOLOGY, 306 (116179). [PMID:36690308]
4. Wu Yue, Yang Jingjuan, Xu Chengmei, Li Qiuqi, Ma Yage, Zhao Shenglan, Zhuang Jiachen, Shen Fei, Wang Qianqian, Feng Fengqin, Zhang Xi. (2022) Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans. Frontiers in Nutrition, 9 [PMID:36483922]
5. Nan Sun, Jiayan Xie, Jianhua Xie, Yi Chen, Xiaobo Hu, Qiang Yu. (2022) Purification, composition and activity of bound polyphenols from mung bean coat dietary fiber. FOOD RESEARCH INTERNATIONAL, 162 (111997). [PMID:36461233]
6. Hanwen Liu, Ying Liu, Ting Zhou, Penghui Zhou, Jianguo Li, Anping Deng. (2022) Ultrasensitive and Specific Detection of Anticancer Drug 5-Fluorouracil in Blood Samples by a Surface-Enhanced Raman Scattering (SERS)-Based Lateral Flow Immunochromatographic Assay. MOLECULES, 27 (13): (4019). [PMID:35807264]
7. Ting Zhou, Guangzhao He, Changjia Hu, Kang Wu, Ying Liu, Jianguo Li, Anping Deng. (2022) Development of a highly sensitive and specific monoclonal antibody-based ELISA coupled with immuno-affinity extraction for the detection of anticancer drug 5-fluorouracil in blood samples. TALANTA, 249 (123655). [PMID:35696979]
8. Xueqing Chen, Weiqun Gao, Yan Sun, Xiaoyan Dong. (2023) Multiple effects of polydopamine nanoparticles on Cu2+-mediated Alzheimer's β-amyloid aggregation. CHINESE JOURNAL OF CHEMICAL ENGINEERING, 54 (144). [PMID:]

References

1. Tao Long, Xue Chen, Yue Zhang, Yu-Jia Zhou, Yan-Ni He, Yun-Fei Zhu, Hai-Jun Fu, Lu Yu, Chong-Lin Yu, Betty Yuen-Kwan Law, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu, Xiao-Gang Zhou. (2023) Protective effects of Radix Stellariae extract against Alzheimer's disease via autophagy activation in Caenorhabditis elegans and cellular models. BIOMEDICINE & PHARMACOTHERAPY, 165 (115261). [PMID:37549461]
2. Yong-Jun Huang, Xiao-Lin Zhong, Yi-Peng Zang, Ming-Han Yang, Jing Lin, Wei-Min Chen. (2023) 3-Hydroxy-pyridin-4(1H)-ones as siderophores mediated delivery of isobavachalcone enhances antibacterial activity against pathogenic Pseudomonas aeruginosa. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 257 (115454). [PMID:37210837]
3. Tisong Liang, Jiexin Zhou, Pu Jing, Zhengjun He, Shunshan Jiao, Wenji Zhao, Qi Tong, Guofu Jia. (2023) Anti-senescence effects of Rhodiola crenulate extracts on LO2 cells and bioactive compounds. JOURNAL OF ETHNOPHARMACOLOGY, 306 (116179). [PMID:36690308]
4. Wu Yue, Yang Jingjuan, Xu Chengmei, Li Qiuqi, Ma Yage, Zhao Shenglan, Zhuang Jiachen, Shen Fei, Wang Qianqian, Feng Fengqin, Zhang Xi. (2022) Sea cucumber (Acaudina leucoprocta) peptides extended the lifespan and enhanced antioxidant capacity via DAF-16/DAF-2/SOD-3/OLD-1/PEPT-1 in Caenorhabditis elegans. Frontiers in Nutrition, 9 [PMID:36483922]
5. Nan Sun, Jiayan Xie, Jianhua Xie, Yi Chen, Xiaobo Hu, Qiang Yu. (2022) Purification, composition and activity of bound polyphenols from mung bean coat dietary fiber. FOOD RESEARCH INTERNATIONAL, 162 (111997). [PMID:36461233]
6. Hanwen Liu, Ying Liu, Ting Zhou, Penghui Zhou, Jianguo Li, Anping Deng. (2022) Ultrasensitive and Specific Detection of Anticancer Drug 5-Fluorouracil in Blood Samples by a Surface-Enhanced Raman Scattering (SERS)-Based Lateral Flow Immunochromatographic Assay. MOLECULES, 27 (13): (4019). [PMID:35807264]
7. Ting Zhou, Guangzhao He, Changjia Hu, Kang Wu, Ying Liu, Jianguo Li, Anping Deng. (2022) Development of a highly sensitive and specific monoclonal antibody-based ELISA coupled with immuno-affinity extraction for the detection of anticancer drug 5-fluorouracil in blood samples. TALANTA, 249 (123655). [PMID:35696979]
8. Xueqing Chen, Weiqun Gao, Yan Sun, Xiaoyan Dong. (2023) Multiple effects of polydopamine nanoparticles on Cu2+-mediated Alzheimer's β-amyloid aggregation. CHINESE JOURNAL OF CHEMICAL ENGINEERING, 54 (144). [PMID:]

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