| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| H424179-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $241.90 |
| Synonyms | juglone | 481-39-0 | 5-Hydroxy-1,4-naphthoquinone | 5-Hydroxy-1,4-naphthalenedione | 5-Hydroxynaphthalene-1,4-dione | Regianin | Nucin | Juglon | Akhnot | Yuglon | C.I. Natural Brown 7 | 8-Hydroxy-1,4-naphthoquinone | 5-Hydroxynaphthoquinone | 1,4-NAPHTHALENEDIONE, 5-HYDROXY- | 5-Hy |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Biochemical and Physiological Mechanisms | Juglone inhibits the transcription of Pol II (RNA polymerase II) by changing the sulfhydryl groups and blocking the assembly of the preinitiation complex. Other studies show that Juglone does not block T7 RNA polymerase but that it inhibits Pol II and Pol |
| Storage Temp | Protected from light,Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | A compound that inhibits RNA polymerases |
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| IUPAC Name | 5-hydroxynaphthalene-1,4-dione |
|---|---|
| INCHI | InChI=1S/C10H6O3/c11-7-4-5-9(13)10-6(7)2-1-3-8(10)12/h1-5,12H |
| InChi Key | KQPYUDDGWXQXHS-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC2=C(C(=O)C=CC2=O)C(=C1)O |
| Isomeric SMILES | C1=CC2=C(C(=O)C=CC2=O)C(=C1)O |
| WGK Germany | 3 |
| RTECS | QJ5775000 |
| PubChem CID | 3806 |
| UN Number | 2811 |
| Packing Group | III |
| Molecular Weight | 174.16 |
| Beilstein | 8308 |
| Reaxy-Rn | 1909764 |
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| Sensitivity | light sensitive |
|---|---|
| Flash Point(°C) | 201.3ºC |
| Boil Point(°C) | 385.8ºC at 760 mmHg |
| Melt Point(°C) | 155°C(lit.) |
| Pictogram(s) | GHS06, GHS09, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H400:Very toxic to aquatic life |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| RTECS | QJ5775000 |
| Reaxy-Rn | 1909764 |
| Class | 6.1 |
| Merck Index | 5269 |
| 1. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang. (2023) “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process. ACS Nano, 17 (18): (18227–18239). [PMID:37668306] |
| 2. Mengfei Tian, Xianming Meng, Naveed Ahmad, Chunying Li, Zhanyu Yuan, Zidan Luo, Yu Zhang, Chunyu Liang, Chunjian Zhao. (2023) Back extraction combined with magnetic solid phase extraction based on bubble column for separation and purification of juglone from Juglans mandshurica Maxim. coproducts. Chemical Engineering and Processing-Process Intensification, 183 (109257). [PMID:] |
| 3. Mengfei Tian, Chunyu Liang, Naveed Ahmad, Chunying Li, Weihao Wang, Yu Zhang, Zidan Luo, Lequn Qiu, Chunjian Zhao. (2022) Proposal and application of a novel extraction and purification technology for juglone from Juglans mandshurica waste branches: Reverse micellar microemulsion combined with magnetic solid phase extraction. CHEMICAL ENGINEERING RESEARCH & DESIGN, 186 (661). [PMID:] |
| 4. Mohsin Pasha, Saier Liu, Minjing Shang, Min Qiu, Yuanhai Su. (2022) A synergistic study on the synthesis of juglone via photooxidation in a UV–Vis LED based photomicroreactor. CHEMICAL ENGINEERING JOURNAL, 445 (136663). [PMID:] |
| 5. Xiao-Fei Shang,Ying-Qian Liu,Xiao Guo,Xiao-Lou Miao,Cheng Chen,Jun-Xiang Zhang,Xiao-Shan Xu,Guan-Zhou Yang,Cheng-Jie Yang,Jun-Cai Li,Xiao-Shuai Zhang. (2018-01-27) Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi.. Scientific reports, 8 ((1)): (1609-1609). [PMID:29371639] |
| 1. Wenzhe Xu, Yang Chen, Ruixu Yang, Yiying Fu, Wanxin Zhuang, Yonggang Wang, Yi Liu, Hao Zhang. (2023) “Reaction”-Like Shaping of Self-Delivery Supramolecular Nanodrugs in the Nanoprecipitation Process. ACS Nano, 17 (18): (18227–18239). [PMID:37668306] |
| 2. Mengfei Tian, Xianming Meng, Naveed Ahmad, Chunying Li, Zhanyu Yuan, Zidan Luo, Yu Zhang, Chunyu Liang, Chunjian Zhao. (2023) Back extraction combined with magnetic solid phase extraction based on bubble column for separation and purification of juglone from Juglans mandshurica Maxim. coproducts. Chemical Engineering and Processing-Process Intensification, 183 (109257). [PMID:] |
| 3. Mengfei Tian, Chunyu Liang, Naveed Ahmad, Chunying Li, Weihao Wang, Yu Zhang, Zidan Luo, Lequn Qiu, Chunjian Zhao. (2022) Proposal and application of a novel extraction and purification technology for juglone from Juglans mandshurica waste branches: Reverse micellar microemulsion combined with magnetic solid phase extraction. CHEMICAL ENGINEERING RESEARCH & DESIGN, 186 (661). [PMID:] |
| 4. Mohsin Pasha, Saier Liu, Minjing Shang, Min Qiu, Yuanhai Su. (2022) A synergistic study on the synthesis of juglone via photooxidation in a UV–Vis LED based photomicroreactor. CHEMICAL ENGINEERING JOURNAL, 445 (136663). [PMID:] |
| 5. Xiao-Fei Shang,Ying-Qian Liu,Xiao Guo,Xiao-Lou Miao,Cheng Chen,Jun-Xiang Zhang,Xiao-Shan Xu,Guan-Zhou Yang,Cheng-Jie Yang,Jun-Cai Li,Xiao-Shuai Zhang. (2018-01-27) Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi.. Scientific reports, 8 ((1)): (1609-1609). [PMID:29371639] |
