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I424638-1ml

1ml

Available within 4-8 weeks(?)

$69.90

Basic Description

Synonyms	idoxuridine \| 5-Iodo-2'-deoxyuridine \| 54-42-2 \| 5-Iododeoxyuridine \| Idoxuridin \| Iododeoxyridine \| Iodoxuridine \| Joddeoxiuridin \| 2'-Deoxy-5-iodouridine \| Herplex \| IUDR \| Idoxene \| Stoxil \| (+)-5-Iodo-2'-deoxyuridine \| IDUR \| Idoxuridinum \| Iduridin \| Kerecid \| Virudox \| Allergan 211 \| 5IUD
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	Selective cytotoxic cell-permeable anti-herpesvirus agent (IC 50 = 4.3 μM). Radiosensitizing. Incorporates into DNA increases susceptibility of cancer cell to radiation damage. Active in vivo.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Idoxuridine is a cytotoxic, anti-viral thymidine analog. A cytotoxic analog of thymidine, antiviral 5-Iodine-2'-deoxyuridine (5-IUdR; IdUrd) is a thiophene thymidine), which has anti-vaccinia virus (orthopox virus) activity. Radiosensitizer.

Product Properties

ALogP	-1

Associated Targets(non-human)

TK Thymidine kinase (276 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Cckar Cholecystokinin A receptor (90 Activities)

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deoA Thymidine phosphorylase (531 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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Enterococcus faecium (13803 Activities)

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Plasmodium falciparum (966862 Activities)

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Human alphaherpesvirus 2 (4932 Activities)

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Human alphaherpesvirus 3 (4092 Activities)

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Oryctolagus cuniculus (11301 Activities)

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Mus musculus (284745 Activities)

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Rattus norvegicus (775804 Activities)

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Cowpox virus (428 Activities)

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Vaccinia virus (4609 Activities)

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Human alphaherpesvirus 1 (11089 Activities)

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Hepatitis B virus (7925 Activities)

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Vesicular stomatitis virus (4460 Activities)

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Duck hepatitis B virus (235 Activities)

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BSC-1 (357 Activities)

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CCRF S-180 (1031 Activities)

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EMT6 (738 Activities)

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L1210 (27553 Activities)

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L5178Y (1809 Activities)

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P815 (244 Activities)

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Vero (26788 Activities)

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KBALB cell line (25 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Serum (58 Activities)

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vpr Aberrant vpr protein (14595 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Macacine alphaherpesvirus 1 (205 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Glra2 Glycine receptor (1745 Activities)

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SARS-CoV-2 (38078 Activities)

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Names and Identifiers

IUPAC Name	1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione
INCHI	InChI=1S/C9H11IN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChi Key	XQFRJNBWHJMXHO-RRKCRQDMSA-N
Canonical SMILES	C1C(C(OC1N2C=C(C(=O)NC2=O)I)CO)O
Isomeric SMILES	C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)I)CO)O
WGK Germany	3
RTECS	YU7700000
PubChem CID	5905
Molecular Weight	354.1
Beilstein	30397
Reaxy-Rn	30397

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

Sensitivity	Air sensitive.Light sensitive.
Specific Rotation[α]	30 ° (C=1, 1mol/L NaOH)
Melt Point(°C)	194°C

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H341:Suspected of causing genetic defects H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P203:Obtain, read and follow all safety instructions before use. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P318:if exposed or concerned, get medical advice. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	YU7700000
Reaxy-Rn	30397
Merck Index	4891

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5-Iodo-2′-deoxyuridine - 10mM in DMSO, high purity , CAS No.54-42-2

Basic Description

Product Properties

Associated Targets(non-human)

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

Solution Calculators

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