Grouped product items

SKU

Size

Availability

Price

Qty

I124244-5g

In stock

$16.90

I124244-10g

10g

Available within 4-8 weeks(?)

$29.90

I124244-25g

25g

In stock

$41.90

I124244-50g

50g

In stock

$75.90

I124244-100g

100g

Available within 8-12 weeks(?)

$135.90

I124244-250g

250g

Available within 4-8 weeks(?)

$304.90

Basic Description

Synonyms	I0219 \| PD006817 \| W-104615 \| Z1269147233 \| 2,4(1H,3H)-Pyrimidinedione, 5-iodo- \| IUR \| SY015873 \| MFCD00006020 \| AC-19702 \| AI3-50390 \| FT-0620521 \| PS-4031 \| 5-IODO-2,4-DIHYDROXYPYRIMIDINE \| AKOS026732157 \| J-802152 \| SCHEMBL7884 \| 5-iodopyrimidine-2,4(
Specifications & Purity	≥99%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice

Associated Targets(Human)

DPYD Tclin Dihydropyrimidine dehydrogenase [NADP(+)] (1 Activities)

Discover Target: DPYD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DPYD Tclin Dihydropyrimidine dehydrogenase (17 Activities)

Discover Target: DPYD

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Raji (5516 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

L1210 (27553 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	5-iodo-1H-pyrimidine-2,4-dione
INCHI	InChI=1S/C4H3IN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)
InChi Key	KSNXJLQDQOIRIP-UHFFFAOYSA-N
Canonical SMILES	C1=C(C(=O)NC(=O)N1)I
Isomeric SMILES	C1=C(C(=O)NC(=O)N1)I
WGK Germany	3
RTECS	YR0525000
PubChem CID	69672
Molecular Weight	237.98
Beilstein	4891
Reaxy-Rn	4891

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
G2416603	Certificate of Analysis	Apr 12, 2024	I124244
L1917113	Certificate of Analysis	Oct 20, 2023	I124244
H1525107	Certificate of Analysis	Apr 14, 2023	I124244
L2206079	Certificate of Analysis	Dec 20, 2022	I124244

Chemical and Physical Properties

Solubility	Slightly soluble in water
Sensitivity	Light Sensitive
Melt Point(°C)	274-276°C

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
RTECS	YR0525000
Reaxy-Rn	4891

References

1. R O Rahn. (1992-07-01) Photochemistry of halogen pyrimidines: iodine release studies.. Photochemistry and photobiology, 56 ((1)): (9-15). [PMID:1508985]
2. M C Willis,B J Hicke,O C Uhlenbeck,T R Cech,T H Koch. (1993-11-19) Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins.. Science (New York, N.Y.), 262 ((5137)): (1255-1257). [PMID:7694369]
3. E Ferrer,M Wiersma,B Kazimierczak,C W Müller,R Eritja. (1997-11-05) Preparation and properties of oligodeoxynucleotides containing 5-iodouracil and 5-bromo- and 5-iodocytosine.. Bioconjugate chemistry, 8 ((5)): (757-761). [PMID:9327142]
4. D L Wong,J G Pavlovich,N O Reich. (1998-02-28) Electrospray ionization mass spectrometric characterization of photocrosslinked DNA-EcoRI DNA methyltransferase complexes.. Nucleic acids research, 26 ((2)): (645-649). [PMID:9421528]
5. T Ueda,K Shinozaki,K Ushizawa,A Yimit,M Tsuboi. (1997-01-01) Raman scattering tensors of 5-iodouracil.. Nucleic acids symposium series, ((37)(37)): (95-96). [PMID:9586016]
6. A Jeltsch,M Roth,T Friedrich. (1999-01-27) Mutational analysis of target base flipping by the EcoRV adenine-N6 DNA methyltransferase.. Journal of molecular biology, 285 ((3)): (1121-1130). [PMID:9918720]
7. Yan Xu,Hiroshi Sugiyama. (2003-09-27) Photoreactivity of 5-iodouracil-containing telomeric DNA.. Nucleic acids research. Supplement (2001), ((3)): (71-72). [PMID:14510385]
8. Yukihide Tomari,Christian Matranga,Benjamin Haley,Natalia Martinez,Phillip D Zamore. (2004-11-20) A protein sensor for siRNA asymmetry.. Science (New York, N.Y.), 306 ((5700)): (1377-1380). [PMID:15550672]
9. Hiren Banerjee,Ravinder Singh. (2008-11-05) A simple crosslinking method, CLAMP, to map the sites of RNA-contacting domains within a protein.. Methods in molecular biology (Clifton, N.J.), 488 (181-190). [PMID:18982291]
10. Jesse J Chen,Ching-Hsuan Tsai,Xin Cai,Allen T Horhota,Larry W McLaughlin,Jack W Szostak. (2009-03-24) Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates.. PloS one, 4 ((3)): (e4949-e4949). [PMID:19305495]
11. Eirini Mitsiki,Anastassios C Papageorgiou,Shalini Iyer,Nethaji Thiyagarajan,Steven H Prior,Darrell Sleep,Chris Finnis,K Ravi Acharya. (2009-06-27) Structures of native human thymidine phosphorylase and in complex with 5-iodouracil.. Biochemical and biophysical research communications, 386 ((4)): (666-670). [PMID:19555658]
12. Supaluk Prachayasittikul,Nirun Sornsongkhram,Ratchanok Pingaew,Apilak Worachartcheewan,Somsak Ruchirawat,Virapong Prachayasittikul. (2009-08-25) Synthesis of N-substituted 5-iodouracils as antimicrobial and anticancer agents.. Molecules (Basel, Switzerland), 14 ((8)): (2768-2779). [PMID:19701123]
13. Ying Liu,Xiao-li Lan,Liang Zhang,Tao Wu,Ri-feng Jiang,Yong-xue Zhang. (2009-11-26) [Myocardial single photon emission tomography imaging of reporter gene expression in rabbits].. Zhonghua xin xue guan bing za zhi, 37 ((6)): (548-553). [PMID:19927639]
14. Abul K Mallik,Wee Keat Cheah,Kaori Shingo,Aika Ejzaki,Makoto Takafuji,Hirotaka Ihara. (2014-05-27) Highly hydrophilic and nonionic poly(2-vinyloxazoline)-grafted silica: a novel organic phase for high-selectivity hydrophilic interaction chromatography.. Analytical and bioanalytical chemistry, 406 ((19)): (4585-4593). [PMID:24858469]
15. Xiaorong Sun,Ellen Ackerstaff,Fuqiu He,Ligang Xing,Hung Tsung Hsiao,Jason A Koutcher,C Clifton Ling,Gloria C Li. (2015-09-30) Visualizing the antivascular effect of bortezomib on the hypoxic tumor microenvironment.. Oncotarget, 6 ((33)): (34732-34744). [PMID:26416246]
16. Carina Hernandez,Jens J Birktoft,Yoel P Ohayon,Arun Richard Chandrasekaran,Hatem Abdallah,Ruojie Sha,Vivian Stojanoff,Chengde Mao,Nadrian C Seeman. (2017-10-11) Self-Assembly of 3D DNA Crystals Containing a Torsionally Stressed Component.. Cell chemical biology, 24 ((11)): (1401-1406). [PMID:28988948]
17. Santanu Mondal,Govindasamy Mugesh. (2018-11-07) Dehalogenation of Halogenated Nucleobases and Nucleosides by Organoselenium Compounds.. Chemistry (Weinheim an der Bergstrasse, Germany), 25 ((7)): (1773-1780). [PMID:30398293]
18. J D Robertson,E Ferguson,M Jay,D J Stalker. (1992-11-01) Noninvasive in vivo percutaneous absorption measurements using X-ray fluorescence.. Pharmaceutical research, 9 ((11)): (1410-1414). [PMID:1475226]
19. K Q Liu,S C Bunnell,C B Gurniak,L J Berg. (1998-06-13) T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells.. The Journal of experimental medicine, 187 ((10)): (1721-1727). [PMID:9584150]
20. K Kawai,H Sugiyama,I Saito. (1997-01-01) Photoreaction of 5-halouracil-containing Z-form DNA.. Nucleic acids symposium series, (37) ((37)): (93-94). [PMID:9586015]
21. S Sastry,B M Ross. (1999-04-23) Probing the interaction of T7 RNA polymerase with promoter.. Biochemistry, 38 ((16)): (4972-4981). [PMID:10213599]
22. T Oyoshi,H Sugiyama,A H Wang. (2000-04-26) Photoreactivity of 5-iodouracil-containing DNA-Sso7d complex.. Nucleic acids symposium series, (42) ((42)): (171-172). [PMID:10780434]
23. Doreen Dobritzsch,Stefano Ricagno,Gunter Schneider,Klaus D Schnackerz,Ylva Lindqvist. (2002-01-18) Crystal structure of the productive ternary complex of dihydropyrimidine dehydrogenase with NADPH and 5-iodouracil. Implications for mechanism of inhibition and electron transfer.. The Journal of biological chemistry, 277 ((15)): (13155-13166). [PMID:11796730]
24. T Oyoshi,H Sugiyama. (2003-07-03) Photoreactivity of 5-iodouracil-containing DNA-Z alpha complex.. Nucleic acids research. Supplement (2001), (1) ((1)): (123-124). [PMID:12836295]
25. Kazuo Tanaka,Taku Kamei,Akimitsu Okamoto. (2006-12-08) Evaluation of novel one-electron reduction with metal in DNA.. Nucleic acids symposium series (2004), (50) ((50)): (127-128). [PMID:17150850]
26. Gaurav Garg,Milind Pande,Ambika Agrawal,Jie Li,Rakesh Kumar. (2016-03-19) Investigation of 4-amino-5-alkynylpyrimidine-2(1H)-ones as anti-mycobacterial agents.. Bioorganic & medicinal chemistry, 24 ((8)): (1771-1777). [PMID:26988804]

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5-Iodouracil - 99%, high purity , CAS No.696-07-1

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

Certificate of Analysis(COA)

Chemical and Physical Properties

Safety and Hazards(GHS)

Related Documents

References

Solution Calculators

Molarity Calculator

Dilution Calculator

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