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5-(N-Methyl-N-isobutyl)-Amiloride - ≥97%, high purity , CAS No.96861-65-3
Basic Description Synonyms NCGC00093562-01 | NCGC00015068-02 | 5-(N-Methyl-N-isobutyl)??amiloride, >=98% (TLC), powder | EU-0100048 | Lopac-A-5585 | SCHEMBL9852472 | DTXSID50242594 | Methylisobutylamiloride | SMR001230841 | 5-Nmnia | SCHEMBL2432777 | CCG-204144 | Pyrazinecarboxamid Specifications & Purity ≥97% Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description 5-(N-Methyl-N-isobutyl)-Amiloride is an NHE inhibitor and possible antitumor agent. 5-(N-Methyl-N-isobutyl)-Amiloride has been shown to depress cardiac function and has also been shown to have a neuroprotective effect that increases the survival of forebrain tissue.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 3-amino-6-chloro-N-(diaminomethylidene)-5-[methyl(2-methylpropyl)amino]pyrazine-2-carboxamide INCHI InChI=1S/C11H18ClN7O/c1-5(2)4-19(3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20) InChi Key RVIUMPLAOXSSGN-UHFFFAOYSA-N Canonical SMILES CC(C)CN(C)C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N Isomeric SMILES CC(C)CN(C)C1=NC(=C(N=C1Cl)C(=O)N=C(N)N)N WGK Germany 3 PubChem CID 73314 Molecular Weight 299.76
Chemical and Physical Properties Solubility Soluble in dilute aqueous acid or DMSO; insoluble in water. Melt Point(°C) 182-192° C
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3
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