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Basic Description
| Synonyms | NSC 4263 | 5-Nitro-1,10-diazaphenanthrene | MFCD00004981 | 5-NP | AKOS003368622 | DTXSID7063346 | Octachloro-hexahydro-methanoisobenzofuran | PD158530 | Zynophos | 10.14272/PDDBTWXLNJNICS-UHFFFAOYSA-N.1 | AMY23551 | 1,10-Phenanthroline, 5-nitro- | NSC4263 |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Platinum chelates of a variety of 5-substituted phenanthrolines, including this compound, were tested for cytotoxicity against L1210 murine leukemia cells. Though all tested compounds had very similar DNA-binding affinities, they exhibited a wide range of |
| Shipped In | Normal |
Associated Targets(Human)
ALDH1A1 Tchem Aldehyde dehydrogenase 1A1 (77053 Activities)
GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
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THP-1 (11052 Activities)
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KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
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L3MBTL1 Tchem Lethal(3)malignant brain tumor-like protein 1 (14536 Activities)
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SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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GMNN Tbio Geminin (128009 Activities)
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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)
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BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)
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ATXN2 Tbio Ataxin-2 (54410 Activities)
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IDH1 Tclin Isocitrate dehydrogenase [NADP] cytoplasmic (40980 Activities)
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Associated Targets(non-human)
Histidine-rich protein (528 Activities)
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Pseudomonas aeruginosa (123386 Activities)
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Klebsiella pneumoniae (43867 Activities)
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Salmonella typhimurium (15756 Activities)
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Staphylococcus aureus (210822 Activities)
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Acinetobacter baumannii (41033 Activities)
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Escherichia coli (133304 Activities)
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Mycobacterium tuberculosis (203094 Activities)
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Plasmodium falciparum (966862 Activities)
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Cryptococcus neoformans (21258 Activities)
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Candida albicans (78123 Activities)
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Ferriprotoporphyrin IX (165 Activities)
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Giardia (1682 Activities)
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Mapt Microtubule-associated protein tau (6 Activities)
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fba Putative fructose-1,6-bisphosphate aldolase (15559 Activities)
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Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
Names and Identifiers
| Pubchem Sid | 488184712 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488184712 |
| IUPAC Name | 5-nitro-1,10-phenanthroline |
| INCHI | InChI=1S/C12H7N3O2/c16-15(17)10-7-8-3-1-5-13-11(8)12-9(10)4-2-6-14-12/h1-7H |
| InChi Key | PDDBTWXLNJNICS-UHFFFAOYSA-N |
| Canonical SMILES | C1=CC2=CC(=C3C=CC=NC3=C2N=C1)[N+](=O)[O-] |
| Isomeric SMILES | C1=CC2=CC(=C3C=CC=NC3=C2N=C1)[N+](=O)[O-] |
| WGK Germany | 3 |
| PubChem CID | 72790 |
| Molecular Weight | 225.21 |
| Beilstein | 196245 |
| Reaxy-Rn | 196245 |
Certificates
Certificate of Analysis(COA)
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 B1301025 | Certificate of Analysis | Oct 14, 2024 | N119911 |
| A2402518 | Certificate of Analysis | Nov 22, 2023 | N119911 |
| A2402519 | Certificate of Analysis | Nov 22, 2023 | N119911 |
| C1820124 | Certificate of Analysis | Jan 22, 2022 | N119911 |
| C2208144 | Certificate of Analysis | Jul 30, 2021 | N119911 |
| D2321373 | Certificate of Analysis | Jul 30, 2021 | N119911 |
Chemical and Physical Properties
| Solubility | Insoluble in water |
|---|---|
| Melt Point(°C) | 202°C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
| WGK Germany | 3 |
| Reaxy-Rn | 196245 |