5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide - >99%, high purity , CAS No.355022-97-8

  • ≥99%
Item Number
N344168
Grouped product items
SKUSizeAvailabilityPrice Qty
N344168-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$128.90
N344168-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$565.90

a GABAAα2 agonist

Basic Description

Specifications & Purity≥99%
Storage TempRoom temperature
Shipped InNormal
Product Description

TCS 1205 is reported to be a GABA|A|α1 partial agonist and GABA|A|α2 agonist|in vitro.

Product Properties

Ki DataGABAA α2: Ki= 14 nM; GABAA α1: Ki= 121 nM

Associated Targets(Human)

GABRA2 Tclin GABA receptor alpha-2 subunit (271 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GABRB2 Tclin GABA A receptor alpha-3/beta-2/gamma-2 (101 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrp GABA-A receptor; anion channel (5731 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrg2 GABA-A receptor; alpha-1/beta-2/gamma-2 (554 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Gabrg2 GABA A receptor alpha-5/beta-3/gamma-2 (149 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 2-(5-nitro-1H-indol-3-yl)-2-oxo-N-[(1R)-1-phenylethyl]acetamide
INCHI InChI=1S/C18H15N3O4/c1-11(12-5-3-2-4-6-12)20-18(23)17(22)15-10-19-16-8-7-13(21(24)25)9-14(15)16/h2-11,19H,1H3,(H,20,23)/t11-/m1/s1
InChi Key VCKKJKQZHHPPDR-LLVKDONJSA-N
Canonical SMILES CC(C1=CC=CC=C1)NC(=O)C(=O)C2=CNC3=C2C=C(C=C3)[N+](=O)[O-]
Isomeric SMILES C[C@H](C1=CC=CC=C1)NC(=O)C(=O)C2=CNC3=C2C=C(C=C3)[N+](=O)[O-]
PubChem CID 10315001
Molecular Weight 337.33

Certificates

Certificate of Analysis(COA)

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Chemical and Physical Properties

SolubilitySoluble in DMSO (100 mM).
Specific Rotation[α]α20D-45.7°, c = 1.2 in DMF

Related Documents

Solution Calculators