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5(S)-HPETE - 100 ug/mL in ethanol, high purity , CAS No.71774-08-8, Agonist of OXE receptor;Activator of TRPV1
a histamine release and calcium flux augmenter
Basic Description Synonyms 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid | 5(S)-HPETE | IDI1_033915 | (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid | SR-01000946955 | 5(S)-HpETE Lipid Maps(R) MS Standard | 6,8,11,14-Eicosatetraenoicacid, 5-hydroperoxy-, (5 Specifications & Purity Moligand™, 100 ug/mL in ethanol Storage Temp Protected from light,Store at -80°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ACTIVATOR, AGONIST Mechanism of action Agonist of OXE receptor;Activator of TRPV1 Note 售完停产 Product Description 5(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid produced by 5-lipoxygenase metabolism of arachidonic acid and a biosynthetic precursor to leukotrienes. 5(S)-HPETE is described to induce c-fos without inducing c-jun in TA1 cells, suggesting that c-fos induction by TNF may be HPETE-mediated. 5(S)-HPETE is also described to modulate histamine release from human basophils.
Associated Targets(Human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid INCHI InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1 InChi Key JNUUNUQHXIOFDA-JGKLHWIESA-N Canonical SMILES CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)OO Isomeric SMILES CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)OO PubChem CID 5280778 Molecular Weight 336.47
Chemical and Physical Properties Solubility Soluble in ethanol Sensitivity Air and light sensitive Boil Point(°C) 78° C
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