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5(S)-HPETE - 100 ug/mL in ethanol, high purity , CAS No.71774-08-8, Agonist of OXE receptor;Activator of TRPV1

Moligand™
100 ug/mL in ethanol

CAS#: 71774-08-8
Formula: C₂₀H₃₂O₄
Molecular Weight: 336.47
PubChem CID: 5280778

Item Number

H342777

Grouped product items
SKU	Size	Availability	Price	Qty
H342777-50μg	50μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$171.90
H342777-100μg	100μg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$318.90

a histamine release and calcium flux augmenter

View related series

OXE receptor Agonist TRPV1 Activator

Basic Description

Synonyms	5(S)-HPETE\|5S-HpETE\|71774-08-8\|5(S)-Hydroperoxyeicosatetraenoic acid\|5(S)?-?HPETE\|(5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid\|CHEBI:15632\|5S-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid\|5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatet
Specifications & Purity	Moligand™, 100 ug/mL in ethanol
Storage Temp	Protected from light,Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ACTIVATOR, AGONIST
Mechanism of action	Agonist of OXE receptor;Activator of TRPV1
Note	售完停产
Product Description	5(S)-HPETE is a monohydroperoxy polyunsaturated fatty acid produced by 5-lipoxygenase metabolism of arachidonic acid and a biosynthetic precursor to leukotrienes. 5(S)-HPETE is described to induce c-fos without inducing c-jun in TA1 cells, suggesting that c-fos induction by TNF may be HPETE-mediated. 5(S)-HPETE is also described to modulate histamine release from human basophils.

Associated Targets

TRPV1 Tclin Transient receptor potential cation channel subfamily V member 1 1 Activities

Discover Target: TRPV1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 0 Activities

Discover Target: RGS4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MGST2 Tbio Microsomal glutathione S-transferase 2 0 Activities

Discover Target: MGST2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OXER1 Tchem Oxoeicosanoid receptor 1 1 Activities

Discover Target: OXER1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid
INCHI	InChI=1S/C20H32O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-16-19(24-23)17-15-18-20(21)22/h6-7,9-10,12-14,16,19,23H,2-5,8,11,15,17-18H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-,16-14+/t19-/m1/s1
InChi Key	JNUUNUQHXIOFDA-JGKLHWIESA-N
Canonical SMILES	CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)OO
Isomeric SMILES	CCCCC/C=C\C/C=C\C/C=C\C=C\[C@H](CCCC(=O)O)OO
PubChem CID	5280778
Molecular Weight	336.47

PubChem CID

ChEBI

ChEMBL Ligand

CAS Registry No.

Wikipedia

Arachidonic acid 5-hydroperoxide

GPCRdb Ligand

5S-HPETE

Certificates

Certificate of Analysis(COA)

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3 results found

Lot Number	Certificate Type	Date	Item
H2212345	Certificate of Analysis	Jul 07, 2022	H342777
G2227070	Certificate of Analysis	Jul 07, 2022	H342777
H2209231	Certificate of Analysis	Jul 07, 2022	H342777

Solubility

Soluble in ethanol

Sensitivity

Air and light sensitive

Boil Point(°C)

78° C

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