Determine the necessary mass, volume, or concentration for preparing a solution.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
Basic Description
| Synonyms | 566-65-4 | 5a-Pregnane-3,20-dione | 5alpha-Pregnane-3,20-dione | 3,20-Allopregnanedione | 5-alpha-Dihydroprogesterone | 5alpha-Dihydroprogesterone | 3,20-Dioxo-5alpha-pregnane | allopregnandione | 5alpha-Pregnan-3,20-dione | Allopregnan-3,20-dione | 5.alpha.-Dihydroprogester |
|---|---|
| Specifications & Purity | 2mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
Associated Targets(Human)
PGR Tclin Progesterone receptor (0 Activities)
NR1I3 Tchem Nuclear receptor subfamily 1 group I member 3 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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GPBAR1 Tchem G-protein coupled bile acid receptor 1 (0 Activities)
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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PGR Tclin Progesterone receptor (8562 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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HEp-2 (3859 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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GPBAR1 Tchem G-protein coupled bile acid receptor 1 (1723 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Associated Targets(non-human)
Nr1i3 Constitutive androstane receptor (427 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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rep Replicase polyprotein 1ab (378 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SARS-CoV-2 (38078 Activities)
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Names and Identifiers
| IUPAC Name | (5S,8R,9S,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one |
|---|---|
| INCHI | InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14,16-19H,4-12H2,1-3H3/t14-,16-,17+,18-,19-,20-,21+/m0/s1 |
| InChi Key | XMRPGKVKISIQBV-BJMCWZGWSA-N |
| Canonical SMILES | CC(=O)C1CCC2C1(CCC3C2CCC4C3(CCC(=O)C4)C)C |
| Isomeric SMILES | CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@@H]4[C@@]3(CCC(=O)C4)C)C |
| PubChem CID | 92810 |
| Molecular Weight | 316.48 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Specific Rotation[α] | 118° (C=1,CHCl3) |
|---|---|
| Melt Point(°C) | 204 °C |
Safety and Hazards(GHS)
| Pictogram(s) | GHS08, GHS07 |
|---|---|
| Signal | Warning |
| Hazard Statements | H351:Suspected of causing cancer H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H361:Suspected of damaging fertility or the unborn child H361fd:Suspected of damaging fertility; Suspected of damaging the unborn child |
| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. |
| Merck Index | 272 |
Related Documents
Citations of This Product
| 1. An W, Lin H, Ma L, Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y et al.. (2022) Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.. Proc Natl Acad Sci U S A, 119 (15): (e2117004119). [PMID:35394864] |
References
| 1. An W, Lin H, Ma L, Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y et al.. (2022) Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.. Proc Natl Acad Sci U S A, 119 (15): (e2117004119). [PMID:35394864] |