6,7-Dimethoxycoumarin - analytical standard，≥98%, high purity , CAS No.120-08-1

Item Number

D101245

• Synonyms: Scoparone | 120-08-1 | 6,7-DIMETHOXYCOUMARIN | 6,7-Dimethylesculetin | Escoparone | Scoparon | Aesculetin dimethyl ether | 6,7-Dimethoxy-2H-chromen-2-one | Esculetin dimethyl ether | 6,7-Dimethoxy-2-benzopyrone | 6,7-dimethoxychromen-2-one | Scopoletin methyl ether | o-Methylsco
• Specifications & Purity: analytical standard, ≥98%
• Shipped In: Normal
• Grade: analytical standard
• Note: 10mg卖完停产，不再备货

Product Description

Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. It has been shown to clear the accumulation of bilirubin by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation through activation of PKA and CaMKII? in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells.
An agent that can up-regulate the expression and activate CAR