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Basic Description
| Synonyms | Scoparone | 120-08-1 | 6,7-DIMETHOXYCOUMARIN | 6,7-Dimethylesculetin | Escoparone | Scoparon | Aesculetin dimethyl ether | 6,7-Dimethoxy-2H-chromen-2-one | Esculetin dimethyl ether | 6,7-Dimethoxy-2-benzopyrone | 6,7-dimethoxychromen-2-one | Scopoletin methyl ether | o-Methylsco |
|---|---|
| Specifications & Purity | 10mM in DMSO |
| Storage Temp | Store at -80°C |
| Shipped In | Ice chest + Ice pads |
| Product Description | Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the CAR (constitutive androstane receptor) found in the liver. It has been shown to clear the accumulation of bilirubin by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation through activation of PKA and CaMKII? in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells. |
Associated Targets(Human)
MCL1 Tchem Induced myeloid leukemia cell differentiation protein Mcl-1 (0 Activities)
BACE1 Tchem Beta-secretase 1 (0 Activities)
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ACHE Tclin Acetylcholinesterase (0 Activities)
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MAOB Tclin Amine oxidase [flavin-containing] B (0 Activities)
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ALDH2 Tclin Aldehyde dehydrogenase, mitochondrial (0 Activities)
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ALDH2 Tclin Aldehyde dehydrogenase (509 Activities)
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ACHE Tclin Acetylcholinesterase (18204 Activities)
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BACE1 Tchem Beta-secretase 1 (15641 Activities)
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DLD-1 (17511 Activities)
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HL-60 (67320 Activities)
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U-937 (7138 Activities)
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A549 (127892 Activities)
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MCL1 Tchem Induced myeloid leukemia cell differentiation protein Mcl-1 (3820 Activities)
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Associated Targets(non-human)
Globisporangium ultimum (223 Activities)
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Agrobacterium tumefaciens (620 Activities)
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Staphylococcus aureus (210822 Activities)
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Escherichia coli (133304 Activities)
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Bacillus subtilis (32866 Activities)
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Mycobacterium tuberculosis (203094 Activities)
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Rhizomucor miehei (120 Activities)
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Leishmania infantum (5912 Activities)
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Candida albicans (78123 Activities)
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Leishmania amazonensis (3813 Activities)
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Leishmania braziliensis (1091 Activities)
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Leishmania donovani (89745 Activities)
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Leishmania major (2877 Activities)
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Leishmania mexicana (936 Activities)
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Artemia (698 Activities)
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Leishmania chagasi (396 Activities)
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Rhizoctonia solani (2251 Activities)
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Maob Monoamine oxidase (439 Activities)
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colH Collagenase ColH (30 Activities)
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Names and Identifiers
| IUPAC Name | 6,7-dimethoxychromen-2-one |
|---|---|
| INCHI | InChI=1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3 |
| InChi Key | GUAFOGOEJLSQBT-UHFFFAOYSA-N |
| Canonical SMILES | COC1=C(C=C2C(=C1)C=CC(=O)O2)OC |
| Isomeric SMILES | COC1=C(C=C2C(=C1)C=CC(=O)O2)OC |
| WGK Germany | 3 |
| RTECS | GN6550000 |
| PubChem CID | 8417 |
| UN Number | 2811 |
| Molecular Weight | 206.19 |
Certificates
Certificate of Analysis(COA)
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Chemical and Physical Properties
| Melt Point(°C) | 143-145°C |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS06, GHS07 |
|---|---|
| Signal | Danger |
| Hazard Statements | H319:Causes serious eye irritation H301:Toxic if swallowed |
| Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. |
| WGK Germany | 3 |
| RTECS | GN6550000 |