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6-amino-8-(furan-2-yl)-4-thia-2-azatricyclo[7.7.0.03,7]hexadeca-1(9),2,5,7-tetraene-5-carboxamide , CAS No.A609124, Inhibitor of eukaryotic elongation factor 2 kinase

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6-amino-8-(furan-2-yl)-4-thia-2-azatricyclo[7.7.0.03,7]hexadeca-1(9),2,5,7-tetraene-5-carboxamide , CAS No.A609124, Inhibitor of eukaryotic elongation factor 2 kinase

Moligand™

PubChem CID: 46830215

Item Number

A609124

Grouped product items
SKU	Size	Availability	Price	Qty
A609124-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,000.90
A609124-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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eukaryotic elongation factor 2 kinase Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of eukaryotic elongation factor 2 kinase

Associated Targets(Human)

EEF2K Tchem Eukaryotic elongation factor 2 kinase (1 Activities)

Discover Target: EEF2K

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EEF2K Tchem Serine/threonine-protein kinase EEF2K (1246 Activities)

Discover Target: EEF2K

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A549 (127892 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

INCHI	InChI=1S/C19H21N3O2S/c20-16-15-14(13-9-6-10-24-13)11-7-4-2-1-3-5-8-12(11)22-19(15)25-17(16)18(21)23/h6,9-10H,1-5,7-8,20H2,(H2,21,23)
InChi Key	YKPDLYPZCGMXBO-UHFFFAOYSA-N
Canonical SMILES	NC(=O)c1sc2c(c1N)c(c1ccco1)c1c(n2)CCCCCCC1
Isomeric SMILES	C1CCCC2=C(CCC1)N=C3C(=C2C4=CC=CO4)C(=C(S3)C(=O)N)N
PubChem CID	46830215

Certificates

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References

1. Lockman JW, Reeder MD, Suzuki K, Ostanin K, Hoff R, Bhoite L, Austin H, Baichwal V, Adam Willardsen J. (2010) Inhibition of eEF2-K by thieno[2,3-b]pyridine analogues.. Bioorg Med Chem Lett, 20 (7): (2283-6). [PMID:20189382] [10.1021/op500134e]

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