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6-chloro-2-(1H-indol-3-yl)-4-phenylquinoline , CAS No.C608630, Inhibitor of carboxyl ester lipase;Inhibitor of elastase; neutrophil expressed

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6-chloro-2-(1H-indol-3-yl)-4-phenylquinoline , CAS No.C608630, Inhibitor of carboxyl ester lipase;Inhibitor of elastase; neutrophil expressed

Moligand™

PubChem CID: 54613196

Item Number

C608630

Grouped product items
SKU	Size	Availability	Price	Qty
C608630-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
C608630-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

View related series

carboxyl ester lipase Inhibitor elastase，neutrophil expressed Inhibitor

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of carboxyl ester lipase;Inhibitor of elastase; neutrophil expressed

Associated Targets(Human)

CEL Tchem Bile salt-activated lipase (0 Activities)

Discover Target: CEL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ELANE Tclin Neutrophil elastase (1 Activities)

Discover Target: ELANE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

F2 Tclin Thrombin (11687 Activities)

Discover Target: F2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ELANE Tclin Leukocyte elastase (8173 Activities)

Discover Target: ELANE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

CTSL Cathepsin L (58 Activities)

Discover Target: CTSL

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	6-chloro-2-(1H-indol-3-yl)-4-phenylquinoline
INCHI	InChI=1S/C23H15ClN2/c24-16-10-11-22-19(12-16)18(15-6-2-1-3-7-15)13-23(26-22)20-14-25-21-9-5-4-8-17(20)21/h1-14,25H
InChi Key	LTUZPODERZUPRD-UHFFFAOYSA-N
Canonical SMILES	Clc1ccc2c(c1)c(cc(n2)c1c[nH]c2c1cccc2)c1ccccc1
Isomeric SMILES	C1=CC=C(C=C1)C2=CC(=NC3=C2C=C(C=C3)Cl)C4=CNC5=CC=CC=C54
PubChem CID	54613196

Database links

PubChem CID	54613196
ChEMBL Ligand	CHEMBL3125346

Certificates

Certificate of Analysis(COA)

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References

1. Muscia GC, Hautmann S, Buldain GY, Asís SE, Gütschow M. (2014) Synthesis and evaluation of 2-(1H-indol-3-yl)-4-phenylquinolines as inhibitors of cholesterol esterase.. Bioorg Med Chem Lett, 24 (6): (1545-9). [PMID:24556381] [10.1021/op500134e]

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