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6-Chloronicotinic Acid - 99%, high purity , CAS No.5326-23-8

2 Citations
  • ≥99%
Item Number
C128115
Grouped product items
SKUSizeAvailabilityPrice Qty
C128115-5g
5g
In stock
$33.90
C128115-10g
10g
In stock
$51.90
C128115-25g
25g
In stock
$99.90
C128115-100g
100g
In stock
$359.90
C128115-500g
500g
In stock
$1,615.90
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Chloropyridine Halogenated heterocyclic block

Basic Description

Synonyms6-Chloronicotinic acid | 5326-23-8 | 6-Chloropyridine-3-carboxylic acid | 6-Chloro-3-pyridinecarboxylic acid | 3-Pyridinecarboxylic acid, 6-chloro- | 6-Chloro-nicotinic acid | 6ChloroNichotinicAcid | MFCD00006241 | 2-CHLORO-5-PYRIDINECARBOXYLIC ACID | NSC-277 | 99V0U0120A | 6-
Specifications & Purity≥99%
Shipped InNormal
Product Description

6-Chloropyridine-3-carboxylic acid (6-chloronicotinic acid/6-CNA) has been used to study its photolytic and photocatalytic degradation. 6-CNA is a degradation product of neonicotinoid insecticides imidacloprid and acetamiprid and is known to appear in different environmental matrices.The product has been used as a media component during the isolation of 6-CNA degrading bacterial strain from imidacloprid-exposed soil samples.

Associated Targets(Human)

NAPRT Tchem Nicotinate phosphoribosyltransferase (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
TYR Tclin Tyrosinase (717 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PLK1 Tchem Serine/threonine-protein kinase PLK1 (28605 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
AOX1 Tchem Aldehyde oxidase (429 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
GLS Tchem Glutaminase kidney isoform, mitochondrial (16997 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
NAPRT Tchem Nicotinate phosphoribosyltransferase (37 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Staphylococcus aureus (210822 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
norA Quinolone resistance protein norA (2171 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cat Catalase (15 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

Pubchem Sid488185694
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488185694
IUPAC Name 6-chloropyridine-3-carboxylic acid
INCHI InChI=1S/C6H4ClNO2/c7-5-2-1-4(3-8-5)6(9)10/h1-3H,(H,9,10)
InChi Key UAWMVMPAYRWUFX-UHFFFAOYSA-N
Canonical SMILES C1=CC(=NC=C1C(=O)O)Cl
Isomeric SMILES C1=CC(=NC=C1C(=O)O)Cl
WGK Germany 3
PubChem CID 79222
Molecular Weight 157.55
Beilstein 115993
Reaxy-Rn 115993

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

13 results found

Lot NumberCertificate TypeDateItem
D2410255Certificate of AnalysisMar 20, 2024 C128115
D2410256Certificate of AnalysisMar 20, 2024 C128115
F23141002Certificate of AnalysisMay 11, 2023 C128115
F23141005Certificate of AnalysisMay 11, 2023 C128115
F23141006Certificate of AnalysisMay 11, 2023 C128115
F23141011Certificate of AnalysisMay 11, 2023 C128115
F23141016Certificate of AnalysisMay 11, 2023 C128115
F2314958Certificate of AnalysisMay 11, 2023 C128115
F2314977Certificate of AnalysisMay 11, 2023 C128115
F2314997Certificate of AnalysisMay 11, 2023 C128115
G1520053Certificate of AnalysisMar 08, 2023 C128115
C2329077Certificate of AnalysisOct 21, 2021 C128115
C2329235Certificate of AnalysisOct 21, 2021 C128115

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Chemical and Physical Properties

SolubilitySoluble in Methanol,Ether,Ethanol; Slightly soluble in Chloroform,Benzene

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

WGK Germany 3
Reaxy-Rn 115993

Related Documents

 SDS

 Specification Sheet

Citations of This Product

1. Dong Li, Chunran Zhou, Shuai Wang, Zhan Hu, Jia Xie, Canping Pan, Ranfeng Sun.  (2023)  Imidacloprid-induced stress affects the growth of pepper plants by disrupting rhizosphere-plant microbial and metabolite composition.  SCIENCE OF THE TOTAL ENVIRONMENT,  898  (165395).  [PMID:37437628]
2. Jingwen Zhang, Junning Liu, Yuheng Wang, Yong Wang, Ruiqin Yang, Xinyang Zhou.  (2023)  Simultaneous determination of ten neonicotinoid insecticides and a metabolite in human whole blood by QuEChERS coupled with UPLC-Q Exactive orbitrap high-resolution mass spectrometry.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1222  (123689).  [PMID:37059012]

References

1. D R Schneider,C D Parker.  (1982-11-01)  Effect of pyridines on phenotypic properties of Bordetella pertussis..  Infection and immunity,  38  ((2)): (548-553).  [PMID:6292105]
2. A Garrido Frenich,F J Egea González,J L Martínez Vidal,P Parrilla Vázquez,M Mateu Sánchez.  (2000-03-17)  Determination of imidacloprid and its metabolite 6-chloronicotinic acid in greenhouse air by high-performance liquid chromatography with diode-array detection..  Journal of chromatography. A,  869  ((1-2)): (497-504).  [PMID:10720263]
3. M D Gil García,M Martínez Galera,R Santiago Valverde,A Galanti,S Girotti.  (2007-02-28)  Column switching liquid chromatography and post-column photochemically fluorescence detection to determine imidacloprid and 6-chloronicotinic acid in honeybees..  Journal of chromatography. A,  1147  ((1)): (17-23).  [PMID:17324438]
4. Mehmet Karabacak,Mustafa Kurt.  (2008-03-25)  Comparison of experimental and density functional study on the molecular structure, infrared and Raman spectra and vibrational assignments of 6-chloronicotinic acid..  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy,  71  ((3)): (876-883).  [PMID:18358772]
5. Won-Bo Shim,Maria E Yakovleva,Kyeong-Yeol Kim,Bo-Ram Nam,Ekaterina S Vylegzhanina,Alexander A Komarov,Sergei A Eremin,Duck-Hwa Chung.  (2009-01-15)  Development of fluorescence polarization immunoassay for the rapid detection of 6-chloronicotinic acid: main metabolite of neonicotinoid insecticides..  Journal of agricultural and food chemistry,  57  ((3)): (791-796).  [PMID:19140717]
6. Romina Zabar,Darko Dolenc,Tina Jerman,Mladen Franko,Polonca Trebše.  (2011-08-02)  Photolytic and photocatalytic degradation of 6-chloronicotinic acid..  Chemosphere,  85  ((5)): (861-868).  [PMID:21802113]
7. Valéria Guzsvány,Ljiljana Rajić,Branislav Jović,Dejan Orčić,János Csanádi,Sanja Lazić,Biljana Abramović.  (2012-07-05)  Spectroscopic monitoring of photocatalytic degradation of the insecticide acetamiprid and its degradation product 6-chloronicotinic acid on TiO₂ catalyst..  Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering,  47  ((12)): (1919-1929).  [PMID:22755539]
8. Gretty Ettiene,Roberto Bauza,María R Plata,Ana M Contento,Angel Ríos.  (2012-09-22)  Determination of neonicotinoid insecticides in environmental samples by micellar electrokinetic chromatography using solid-phase treatments..  Electrophoresis,  33  ((19-20)): (2969-2977).  [PMID:22997021]
9. Mahrous M Kandil,Carmen Trigo,William C Koskinen,Michael J Sadowsky.  (2015-05-02)  Isolation and Characterization of a Novel Imidacloprid-Degrading Mycobacterium sp. Strain MK6 from an Egyptian Soil..  Journal of agricultural and food chemistry,  63  ((19)): (4721-4727).  [PMID:25932751]
10. Dangqin Jin,Qin Xu,Liangyun Yu,Airong Mao,Xiaoya Hu.  (2015-10-17)  A novel sensor for the detection of acetamiprid in vegetables based on its photocatalytic degradation compound..  Food chemistry,  194  (959-965).  [PMID:26471640]
11. F J Uroz,F J Arrebola,F J Egea-González,J L Martínez-Vidal.  (2001-09-06)  Monitoring of 6-chloronicotinic acid in human urine by gas chromatography-tandem mass spectrometry as indicator of exposure to the pesticide imidacloprid..  The Analyst,  126  ((8)): (1355-1358).  [PMID:11534604]
12. A Segura Carretero,C Cruces-Blanco,S Pérez Durán,A Fernández Gutiérrez.  (2003-08-06)  Determination of imidacloprid and its metabolite 6-chloronicotinic acid in greenhouse air by application of micellar electrokinetic capillary chromatography with solid-phase extraction..  Journal of chromatography. A,  1003  ((1-2)): (189-195).  [PMID:12899308]
13. Fabienne Hoffmann-Emery,Hans Hilpert,Michelangelo Scalone,Pius Waldmeier.  (2006-02-25)  Efficient synthesis of novel NK1 receptor antagonists: selective 1,4-addition of grignard reagents to 6-chloronicotinic acid derivatives..  The Journal of organic chemistry,  71  ((5)): (2000-2008).  [PMID:16496986]
14. Kumiko Taira,Yoshiko Aoyama,Tomonori Kawakami,Motoyuki Kamata,Toru Aoi.  (2011-09-29)  [Detection of chloropyridinyl neonicotinoid insecticide metabolite 6-chloronicotinic acid in the urine: six cases with subacute nicotinic symptoms]..  Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology,  24  ((3)): (222-230).  [PMID:21950025]
15. Madhura Shettigar,Stephen Pearce,Rinku Pandey,Fazlurrahman Khan,Susan J Dorrian,Sahil Balotra,Robyn J Russell,John G Oakeshott,Gunjan Pandey.  (2012-12-12)  Cloning of a novel 6-chloronicotinic acid chlorohydrolase from the newly isolated 6-chloronicotinic acid mineralizing Bradyrhizobiaceae strain SG-6C..  PloS one,  7  ((11)): (e51162-e51162).  [PMID:23226482]
16. Romila Akoijam,Balwinder Singh.  (2014-06-04)  Metabolic degradation of imidacloprid in paddy field soil..  Environmental monitoring and assessment,  186  ((10)): (5977-5984).  [PMID:24891072]
17. Dong Li, Chunran Zhou, Shuai Wang, Zhan Hu, Jia Xie, Canping Pan, Ranfeng Sun.  (2023)  Imidacloprid-induced stress affects the growth of pepper plants by disrupting rhizosphere-plant microbial and metabolite composition.  SCIENCE OF THE TOTAL ENVIRONMENT,  898  (165395).  [PMID:37437628]
18. Jingwen Zhang, Junning Liu, Yuheng Wang, Yong Wang, Ruiqin Yang, Xinyang Zhou.  (2023)  Simultaneous determination of ten neonicotinoid insecticides and a metabolite in human whole blood by QuEChERS coupled with UPLC-Q Exactive orbitrap high-resolution mass spectrometry.  JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES,  1222  (123689).  [PMID:37059012]

Solution Calculators

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