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6-Fluoro-DL-tryptophan - 98%, high purity , CAS No.7730-20-3, Inhibitor of L-Tryptophan hydroxylase 1;Inhibitor of L-Tryptophan hydroxylase 2
a serotonin (5-HT) synthesis inhibitor
Basic Description Synonyms 6-Fluoro-DL-tryptophan | 7730-20-3 | 6-fluorotryptophan | 2-amino-3-(6-fluoro-1H-indol-3-yl)propanoic acid | DL-Tryptophan, 6-fluoro- | DL-6-Fluorotryptophane | Tryptophan, 6-fluoro-, DL- | 343-92-0 | 6-Fluorotryptophan, DL- | 6-fluoro-D,L-tryptophan | H-6-F-Trp-OH | 3I7LZ8M32 Specifications & Purity Moligand™, ≥98% Storage Temp Store at -20°C,Argon charged Shipped In Ice chest + Ice pads Grade Moligand™ Action Type INHIBITOR Mechanism of action Inhibitor of L-Tryptophan hydroxylase 1;Inhibitor of L-Tryptophan hydroxylase 2 Product Description 6-Fluoro-DL-tryptophan (6-F-TRP) is a serotonin (5-HT) synthesis inhibitor, is metabolized in the brain and may be useful for tracing neuronal serotoninergic pools. 6-F-TRP is used as a competitive inhibitor of tryptophan binding to albumin and passage through the blood brain barrier.
Product Properties pKa pKa: 2.22 (Predicted), pKa: 9.6 (Predicted)
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-amino-3-(6-fluoro-1H-indol-3-yl)propanoic acid INCHI InChI=1S/C11H11FN2O2/c12-7-1-2-8-6(3-9(13)11(15)16)5-14-10(8)4-7/h1-2,4-5,9,14H,3,13H2,(H,15,16) InChi Key YMEXGEAJNZRQEH-UHFFFAOYSA-N Canonical SMILES C1=CC2=C(C=C1F)NC=C2CC(C(=O)O)N Isomeric SMILES C1=CC2=C(C=C1F)NC=C2CC(C(=O)O)N WGK Germany 3 RTECS YN6850000 PubChem CID 94937 Molecular Weight 222.22 Beilstein 482552
Chemical and Physical Properties Solubility Soluble in water (partly), and 0.5 M hydrochloric acid (50 mg/ml). Sensitivity Moisture sensitive. Refractive Index n20D1.67 (Predicted) Specific Rotation[α] α25/D 0°, c = 1 in 1M hydrochloric acid Boil Point(°C) ~450.7° C at 760 mmHg (Predicted) Melt Point(°C) 280-285° C (lit.)(dec.)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 RTECS YN6850000
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